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Stock Based Compensation (Details 1) - Stock options - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Mar. 31, 2018
Dec. 31, 2017
Number of Options Outstanding    
Options outstanding at December 31, 2017 535,617  
Granted 174,272  
Cancelled/forfeited (1,488)  
Options outstanding at March 31, 2018 708,401 535,617
Unvested at March 31, 2018 (552,654)  
Vested and exercisable at March 31, 2018 155,748  
Weighted Average Exercise Price Per Share    
Options outstanding at December 31, 2017 $ 11.10  
Granted 1.56  
Cancelled/forfeited 362.04  
Options outstanding at March 31, 2018 8.02 $ 11.10
Unvested at March 31, 2018 2.93  
Vested and exercisable at March 31, 2018 $ 26.06  
Weighted Average Remaining Contractual Term (Years)    
Options outstanding 8 years 5 months 19 days 8 years 2 months 23 days
Unvested at March 31, 2018 9 months 7 days  
Vested and exercisable at March 31, 2018 6 years 6 months 11 days  
Aggregate Intrinsic Value    
Options outstanding $ 0 $ 0
Unvested at March 31, 2018 0  
Vested and exercisable at March 31, 2018 $ 0