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Stock Based Compensation (Tables)
6 Months Ended
Jun. 30, 2018
Disclosure Of Compensation Related Costs Share-Based Payments [Abstract]  
Schedule of stock based compensation expense
    Three Months Ended
June 30,
    Six Months Ended
June 30,
 
    2017     2018     2017     2018  
General and administrative   49     63     99     122  
Research and development     17       23       36       45  
Stock-based compensation costs before income taxes   66     86     135     167  
Schedule of share option activity
    Number of
Options
Outstanding
    Weighted
Average
Exercise
Price Per Share
    Weighted
Average
Remaining
Contractual
Term (Years)
   

Aggregate
Intrinsic
Value ($000)

 
Options outstanding at December 31, 2017     535,617       11.10       8.23        
Granted     262,728       1.51                  
Cancelled/forfeited     (1,488 )     362.04                  
Options outstanding at June 30, 2018     796,857       7.28       8.41        
Unvested at June 30, 2018     (620,804 )     2.64       8.95        
Vested and exercisable at June 30, 2018     176,053       23.66       6.53