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Stock Based Compensation (Details 1) - Stock options - USD ($) $ / shares in Units, $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2018	Dec. 31, 2017
Number of Options Outstanding
Options outstanding at December 31, 2017	535,617
Granted	262,728	170,853
Cancelled/forfeited	(1,488)
Options outstanding at June 30, 2018	796,857	535,617
Unvested at June 30, 2018	(620,804)
Vested and exercisable at June 30, 2018	176,053
Weighted Average Exercise Price Per Share
Options outstanding at December 31, 2017	$ 11.10
Granted	1.51
Cancelled/forfeited	362.04
Options outstanding at June 30, 2018	7.28	$ 11.10
Unvested at June 30, 2018	2.64
Vested and exercisable at June 30, 2018	$ 23.66
Weighted Average Remaining Contractual Term (Years)
Options outstanding	8 years 4 months 28 days	8 years 2 months 23 days
Unvested at June 30, 2018	8 years 11 months 12 days
Vested and exercisable at June 30, 2018	6 years 6 months 11 days
Aggregate Intrinsic Value
Options outstanding	$ 0	$ 0
Unvested at June 30, 2018	0
Vested and exercisable at June 30, 2018	$ 0

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Represents the amount of difference between fair value of the underlying shares reserved for issuance and exercise price of options unvested.

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Weighted average remaining contractual term for unvested options, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired.

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Weighted average price of options that were either forfeited or expired.

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Gross number of share options (or share units) granted during the period.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Amount by which current fair value of underlying stock exceeds exercise price of fully vested and expected to vest exercisable or convertible options. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Number of fully vested and expected to vest exercisable options that may be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest exercisable or convertible options. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Number of non-vested options outstanding.

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Weighted average grant-date fair value of non-vested options outstanding.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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