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Stock Based Compensation (Tables)
6 Months Ended
Jun. 30, 2019
Disclosure Of Compensation Related Costs Share-Based Payments [Abstract]  
Schedule of stock based compensation expense
   

Three Months Ended
June 30, 

   

Six Months Ended
June 30, 

 
    2018     2019     2018     2019  
General and administrative   $ 63     $ 57     $ 122     $ 112  
Research and development     23       35       45       66  
Stock-based compensation costs before income taxes   $ 86     $ 92     $ 167     $ 178  
Schedule of share option activity
    Number of
Options
Outstanding
    Weighted
Average
Exercise
Price Per Share
   

Weighted
Average
Remaining
Contractual
Term (Years) 

   

Aggregate
Intrinsic
Value ($000) 

 
Options outstanding at December 31, 2018     831,611     $ 6.68       8.13     $  
Granted     1,550,270     $ 0.71                  
Cancelled/forfeited     (39,613 )   $ 2.76                  
Options outstanding at June 30, 2019     2,342,268     $ 2.80       8.90     $  
Unvested at June 30, 2019     (1,827,156 )   $ 1.25       9.15     $  
Vested and exercisable at June 30, 2019     515,112     $ 8,28       8.02     $  
Schedule of fair value of the stock options granted
  Year ended 
December 31, 2018
    Six months
ended 
June 30, 2019
 
Expected term (years)     6       5 – 6  
Risk free interest rate     2.730% – 2.855%     2.105 – 2.610%
Volatility     105% – 107%     103 – 110%
Expected dividend yield over expected term     0.00%     0.00%
Resulting weighted average grant date fair value   $1.25       $0.52 – $0.61