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Stockholders' Equity (Narrative) (Details) |  |  |  |  |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | --- | ---
Dec. 22, 2020 USD ($) | Dec. 18, 2020 $ / shares shares | Apr. 24, 2020 USD ($) | Apr. 21, 2020 $ / shares shares | Oct. 04, 2018 USD ($) shares | Jul. 21, 2017 USD ($) $ / shares shares | Jul. 31, 2017 $ / shares shares | Dec. 31, 2020 USD ($) item $ / shares shares | Dec. 31, 2019 USD ($) $ / shares shares
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.001 | $ 0.001
Preferred stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.001 | $ 0.001
Proceeds from issuance of common stock, net of issuance costs | $ |  |  |  |  |  |  |  | $ 29,705,000 | $ 4,049,000
Proceeds from further issuance of share | $ |  |  |  |  |  |  |  |  | $ 4,049,000
Proceeds from warrants exercised | $ |  |  |  |  |  |  |  | $ 8,800,000 |
Warrants exercised |  |  |  |  |  |  |  | 901,000 |
Common stock, shares outstanding (in shares) |  |  |  |  |  |  |  | 6,246,896 | 859,998
Underwritten Public Offering [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Warrants, exercise price per share | $ / shares |  |  |  |  |  |  |  | $ 40.00 |
Proceeds from issuance of common stock, net of issuance costs | $ |  |  |  |  |  | $ 13,700,000 |  |  |
Warrants outstanding |  |  |  |  |  |  |  | 374,525 |
Warrants exercised |  |  |  |  |  |  |  | 0 | 0
Common Stock [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from further issuance of share | $ |  |  |  |  |  |  |  |  | $ 0
Number of shares issued (in shares) |  |  |  |  |  |  |  |  | 235,126
Common Stock [Member] | Underwritten Public Offering [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Number of common shares called by each warrant |  |  |  |  |  | 1 |  |  |
Warrant to purchase each share of our common stock |  |  |  |  |  | 1 |  |  |
Class B Units [Member] | Underwritten Public Offering [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Number of shares issued (in shares) |  |  |  |  |  | 8,872 |  |  |
Share Price | $ / shares |  |  |  |  |  | $ 1,000 |  |  |
Class B Units [Member] | Common Stock [Member] | Underwritten Public Offering [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Number of common shares issued upon conversion |  |  |  |  |  | 25 |  |  |
Price per share used to determine number of shares of common stock | $ / shares |  |  |  |  |  | $ 1,000.00 |  |  |
Class A Units [Member] | Underwritten Public Offering [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Number of common shares called by each warrant |  |  |  |  |  | 1 |  |  |
Share issue price per share | $ / shares |  |  |  |  |  | $ 40 |  |  |
Number of shares issued (in shares) |  |  |  |  |  | 157,700 |  |  |
Warrant to purchase each share of our common stock |  |  |  |  |  | 1 |  |  |
Acorn Bioventures, LP [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Warrants exercisable date |  |  |  |  |  |  |  | Dec. 18, 2021 |
Warrant outstanding Term |  |  |  |  |  |  |  | 5 years |
Warrants, exercise price per share | $ / shares |  |  |  |  |  |  |  | $ 4.13 |
Warrants outstanding |  |  |  |  |  |  |  | 669,854 |
Proceeds from warrants exercised | $ |  |  |  |  |  |  |  | $ 4,500,000 |
Warrants exercised |  |  |  |  |  |  |  | 0 |
Co-Placement Agents [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Sell of stock, price per share | $ / shares |  |  |  | $ 5.00 |  |  |  |  |
Warrant outstanding Term |  |  |  | 5 years |  |  |  |  |
Proceeds from issuance of stocks/warrants | $ |  |  | $ 18,300,000 |  |  |  |  |  |
Number of common shares called by each warrant |  |  |  |  |  |  |  | 1 |
Warrants, exercise price per share | $ / shares |  |  |  | $ 5.00 |  |  |  | $ 5.00 |
Warrant to purchase each share of our common stock |  |  |  |  |  |  |  | 1 |
Warrants outstanding |  |  |  |  |  |  |  | 3,099,000 |
Warrants exercised |  |  |  |  |  |  |  | 901,000 |
Co-Placement Agents [Member] | Pre Funded Warrants [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Sell of stock, price per share | $ / shares |  |  |  | $ 4.999 |  |  |  |  |
Number of common shares called by each warrant |  |  |  | 1 |  |  |  |  |
Warrants, exercise price per share | $ / shares |  |  |  | $ 0.001 |  |  |  |  |
Warrant to purchase each share of our common stock |  |  |  | 1 |  |  |  |  |
Percentage of outstanding common stock |  |  |  | 4.99% |  |  |  |  |
Outstanding common stock at election of purchaser |  |  |  | 9.99% |  |  |  |  |
Shares issued on conversion of prefunded warrants |  |  |  |  |  |  |  | 2,090,000 |
Number of share sold under the sales agreement |  |  |  | 2,090,000 |  |  |  |  |
Co-Placement Agents [Member] | Common Stock Warrants [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Warrants to purchase shares |  |  |  | 4,000,000 |  |  |  |  |
Number of common shares called by each warrant |  |  |  | 1 |  |  |  |  |
Warrants, exercise price per share | $ / shares |  |  |  | $ 5.00 |  |  |  |  |
Warrant to purchase each share of our common stock |  |  |  | 1 |  |  |  |  |
H.C. Wainwright & Co., LLC [Member] | At Market Issuance [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from issuance of stocks/warrants | $ |  |  |  |  | $ 4,700,000 |  |  |  |
Selling commissions, percentage |  |  |  |  | 3.00% |  |  |  |
Number of share sold under the sales agreement |  |  |  |  | 260,126 |  |  |  |
H.C. Wainwright & Co., LLC [Member] | Maximum [Member] | At Market Issuance [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from further issuance of share | $ |  |  |  |  | $ 5,000,000 |  |  |  |
Common Stock [Member] | Acorn Bioventures, LP [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Number of share sold under the sales agreement |  | 485,912 |  |  |  |  |  |  |
Common Stock [Member] | Co-Placement Agents [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Number of share sold under the sales agreement |  |  |  | 1,910,000 |  |  |  |  |
6% Convertible Exchangeable Preferred Stock [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Preferred stock, shares issued |  |  |  |  |  |  |  | 335,273 | 335,273
Preferred stock, shares outstanding |  |  |  |  |  |  |  | 335,273 | 335,273
Share issue price per share | $ / shares |  |  |  |  |  |  |  | $ 10.00 | $ 10.00
Number of common shares issued upon conversion |  |  |  |  |  |  |  | 0.00025 |
Dividend rate on convertible exchangeable preferred stock (in percent) |  |  |  |  |  |  |  | 6.00% | 6.00%
Liquidation preference (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 10.00 | $ 10.00
Accrued and unpaid dividends in arrears on preferred stock | $ |  |  |  |  |  |  |  |  | $ 700,000
Accrued and unpaid dividends in arrears on preferred stock (in dollars per share) | $ / shares |  |  |  |  |  |  |  | 1.95 |
Shares reserved for future issuance upon conversion |  |  |  |  |  |  |  |  | 85
Conversion price (in dollars per share) | $ / shares |  |  |  |  |  |  |  | 39,480 |
Share Price | $ / shares |  |  |  |  |  |  |  | $ 59,220 |
Percentage of closing sales price of common stock that conversion price must exceed in order for preferred stock to be convertible |  |  |  |  |  |  |  | 150.00% |
Number of trading days within 30 trading days in which the closing price of common stock must exceed conversion price for preferred stock to be convertible |  |  |  |  |  |  |  | 20 days |
Number of trading days during which closing price of common stock must exceed conversion price for at least 20 days in order for the preferred stock to be convertible |  |  |  |  |  |  |  | 30 days |
Number of trading days prior to notice of automatic conversion |  |  |  |  |  |  |  | 5 days |
Number of quarterly periods in which dividends are not paid that triggers the right of preferred stock holders to nominate and elect directors | item |  |  |  |  |  |  |  | 6 |
Interest rate of Convertible Subordinated Debentures (as a percent) |  |  |  |  |  |  |  | 6.00% |
Redemption price per share (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 10.00 |
Debt principal amount per share, basis for exchange (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 10.00 |
Debt instrument, term |  |  |  |  |  |  |  | 25 years |
Preferred stock dividend declared, amount per share | $ / shares |  |  |  |  |  |  |  | $ 0.15 |
Series A Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Preferred stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.001 | $ 0.001
Preferred stock, shares issued |  |  |  |  |  |  | 8,872 | 264 | 264
Preferred stock, shares outstanding |  |  |  |  |  |  |  | 264 | 264
Number of shares converted |  |  |  |  |  |  |  | 6,600 |
Price per share used to determine number of shares of common stock | $ / shares |  |  |  |  |  |  | $ 1,000 |  |
Conversion price of convertible preferred stock | $ / shares |  |  |  |  |  |  | $ 40.00 |  |
Conversion percentage |  |  |  |  |  |  | 9.99% |  |
Measurement period of consecutive trading days used in determining whether specified triggers are met which would allow the entity to require the conversion of all or part of outstanding preferred stock |  |  |  |  |  |  |  | 30 days |
Percentage of blocker provision |  |  |  |  |  |  | 4.99% |  |
Series A Convertible Preferred Stock [Member] | Class B Units [Member] | Underwritten Public Offering [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Number of securities called by each unit |  |  |  |  |  | 1 |  |  |
Series A Convertible Preferred Stock [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Percentage by which the weighted average price of common stock during the measurement period exceeds the initial conversion price which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted |  |  |  |  |  |  |  | 300.00% |
Threshold amount of daily trading volume on each trading day during the measurement period which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted | $ |  |  |  |  |  |  |  | $ 500,000 |
Series B Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Preferred stock, par value (in dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.001 | $ 0.001
Preferred stock, shares issued |  |  |  |  |  |  |  | 237,745 | 0
Preferred stock, shares outstanding |  |  |  |  |  |  |  | 237,745 | 0
Outstanding common stock at election of purchaser |  |  |  |  |  |  |  | 9.99% |
Number of common shares issued upon conversion |  |  |  |  |  |  |  | 5 |
Number of shares converted |  |  |  |  |  |  |  | 5 |
Series B Convertible Preferred Stock [Member] | Acorn Bioventures, LP [Member] |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |
Warrants to purchase shares |  | 669,854 |  |  |  |  |  |  |
Sell of stock, price per share | $ / shares |  | $ 4.18 |  |  |  |  |  | $ 4.18 |
Effective Conversion price per share | $ / shares |  |  |  |  |  |  |  | $ 3.18 |
Warrants exercisable date |  | Dec. 18, 2021 |  |  |  |  |  |  |
Warrant outstanding Term |  | 5 years |  |  |  |  |  |  |
Proceeds from issuance of stocks/warrants | $ | $ 6,900,000 |  |  |  |  |  |  |  |
Number of common shares called by each warrant |  | 0.4 |  |  |  |  |  |  |
Warrants, exercise price per share | $ / shares |  | $ 4.13 |  |  |  |  |  |  |
Warrant to purchase each share of our common stock |  | 0.4 |  |  |  |  |  |  |
Number of share sold under the sales agreement |  | 237,745 |  |  |  |  |  |  |

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