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Stockholders' Equity (Narrative) (Details)
 1 Months Ended 12 Months Ended
Dec. 22, 2020
USD ($)
Dec. 18, 2020
$ / shares
shares
Apr. 24, 2020
USD ($)
Apr. 21, 2020
$ / shares
shares
Oct. 04, 2018
USD ($)
shares
Jul. 21, 2017
USD ($)
$ / shares
shares
Jul. 31, 2017
$ / shares
shares
Dec. 31, 2020
USD ($)
item
$ / shares
shares
Dec. 31, 2019
USD ($)
$ / shares
shares
Class of Stock [Line Items]                  
Common stock, par value (in dollars per share) | $ / shares               $ 0.001 $ 0.001
Preferred stock, par value (in dollars per share) | $ / shares               $ 0.001 $ 0.001
Proceeds from issuance of common stock, net of issuance costs | $               $ 29,705,000 $ 4,049,000
Proceeds from further issuance of share | $                 $ 4,049,000
Proceeds from warrants exercised | $               $ 8,800,000  
Warrants exercised               901,000  
Common stock, shares outstanding (in shares)               6,246,896 859,998
Underwritten Public Offering [Member]                  
Class of Stock [Line Items]                  
Warrants, exercise price per share | $ / shares               $ 40.00  
Proceeds from issuance of common stock, net of issuance costs | $           $ 13,700,000      
Warrants outstanding               374,525  
Warrants exercised               0 0
Common Stock [Member]                  
Class of Stock [Line Items]                  
Proceeds from further issuance of share | $                 $ 0
Number of shares issued (in shares)                 235,126
Common Stock [Member] | Underwritten Public Offering [Member]                  
Class of Stock [Line Items]                  
Number of common shares called by each warrant           1      
Warrant to purchase each share of our common stock           1      
Class B Units [Member] | Underwritten Public Offering [Member]                  
Class of Stock [Line Items]                  
Number of shares issued (in shares)           8,872      
Share Price | $ / shares           $ 1,000      
Class B Units [Member] | Common Stock [Member] | Underwritten Public Offering [Member]                  
Class of Stock [Line Items]                  
Number of common shares issued upon conversion           25      
Price per share used to determine number of shares of common stock | $ / shares           $ 1,000.00      
Class A Units [Member] | Underwritten Public Offering [Member]                  
Class of Stock [Line Items]                  
Number of common shares called by each warrant           1      
Share issue price per share | $ / shares           $ 40      
Number of shares issued (in shares)           157,700      
Warrant to purchase each share of our common stock           1      
Acorn Bioventures, LP [Member]                  
Class of Stock [Line Items]                  
Warrants exercisable date               Dec. 18, 2021  
Warrant outstanding Term               5 years  
Warrants, exercise price per share | $ / shares               $ 4.13  
Warrants outstanding               669,854  
Proceeds from warrants exercised | $               $ 4,500,000  
Warrants exercised               0  
Co-Placement Agents [Member]                  
Class of Stock [Line Items]                  
Sell of stock, price per share | $ / shares       $ 5.00          
Warrant outstanding Term       5 years          
Proceeds from issuance of stocks/warrants | $     $ 18,300,000            
Number of common shares called by each warrant               1  
Warrants, exercise price per share | $ / shares       $ 5.00       $ 5.00  
Warrant to purchase each share of our common stock               1  
Warrants outstanding               3,099,000  
Warrants exercised               901,000  
Co-Placement Agents [Member] | Pre Funded Warrants [Member]                  
Class of Stock [Line Items]                  
Sell of stock, price per share | $ / shares       $ 4.999          
Number of common shares called by each warrant       1          
Warrants, exercise price per share | $ / shares       $ 0.001          
Warrant to purchase each share of our common stock       1          
Percentage of outstanding common stock       4.99%          
Outstanding common stock at election of purchaser       9.99%          
Shares issued on conversion of prefunded warrants               2,090,000  
Number of share sold under the sales agreement       2,090,000          
Co-Placement Agents [Member] | Common Stock Warrants [Member]                  
Class of Stock [Line Items]                  
Warrants to purchase shares       4,000,000          
Number of common shares called by each warrant       1          
Warrants, exercise price per share | $ / shares       $ 5.00          
Warrant to purchase each share of our common stock       1          
H.C. Wainwright & Co., LLC [Member] | At Market Issuance [Member]                  
Class of Stock [Line Items]                  
Proceeds from issuance of stocks/warrants | $         $ 4,700,000        
Selling commissions, percentage         3.00%        
Number of share sold under the sales agreement         260,126        
H.C. Wainwright & Co., LLC [Member] | Maximum [Member] | At Market Issuance [Member]                  
Class of Stock [Line Items]                  
Proceeds from further issuance of share | $         $ 5,000,000        
Common Stock [Member] | Acorn Bioventures, LP [Member]                  
Class of Stock [Line Items]                  
Number of share sold under the sales agreement   485,912              
Common Stock [Member] | Co-Placement Agents [Member]                  
Class of Stock [Line Items]                  
Number of share sold under the sales agreement       1,910,000          
6% Convertible Exchangeable Preferred Stock [Member]                  
Class of Stock [Line Items]                  
Preferred stock, shares issued               335,273 335,273
Preferred stock, shares outstanding               335,273 335,273
Share issue price per share | $ / shares               $ 10.00 $ 10.00
Number of common shares issued upon conversion               0.00025  
Dividend rate on convertible exchangeable preferred stock (in percent)               6.00% 6.00%
Liquidation preference (in dollars per share) | $ / shares               $ 10.00 $ 10.00
Accrued and unpaid dividends in arrears on preferred stock | $                 $ 700,000
Accrued and unpaid dividends in arrears on preferred stock (in dollars per share) | $ / shares               1.95  
Shares reserved for future issuance upon conversion                 85
Conversion price (in dollars per share) | $ / shares               39,480  
Share Price | $ / shares               $ 59,220  
Percentage of closing sales price of common stock that conversion price must exceed in order for preferred stock to be convertible               150.00%  
Number of trading days within 30 trading days in which the closing price of common stock must exceed conversion price for preferred stock to be convertible               20 days  
Number of trading days during which closing price of common stock must exceed conversion price for at least 20 days in order for the preferred stock to be convertible               30 days  
Number of trading days prior to notice of automatic conversion               5 days  
Number of quarterly periods in which dividends are not paid that triggers the right of preferred stock holders to nominate and elect directors | item               6  
Interest rate of Convertible Subordinated Debentures (as a percent)               6.00%  
Redemption price per share (in dollars per share) | $ / shares               $ 10.00  
Debt principal amount per share, basis for exchange (in dollars per share) | $ / shares               $ 10.00  
Debt instrument, term               25 years  
Preferred stock dividend declared, amount per share | $ / shares               $ 0.15  
Series A Convertible Preferred Stock [Member]                  
Class of Stock [Line Items]                  
Preferred stock, par value (in dollars per share) | $ / shares               $ 0.001 $ 0.001
Preferred stock, shares issued             8,872 264 264
Preferred stock, shares outstanding               264 264
Number of shares converted               6,600  
Price per share used to determine number of shares of common stock | $ / shares             $ 1,000    
Conversion price of convertible preferred stock | $ / shares             $ 40.00    
Conversion percentage             9.99%    
Measurement period of consecutive trading days used in determining whether specified triggers are met which would allow the entity to require the conversion of all or part of outstanding preferred stock               30 days  
Percentage of blocker provision             4.99%    
Series A Convertible Preferred Stock [Member] | Class B Units [Member] | Underwritten Public Offering [Member]                  
Class of Stock [Line Items]                  
Number of securities called by each unit           1      
Series A Convertible Preferred Stock [Member] | Minimum [Member]                  
Class of Stock [Line Items]                  
Percentage by which the weighted average price of common stock during the measurement period exceeds the initial conversion price which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted               300.00%  
Threshold amount of daily trading volume on each trading day during the measurement period which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted | $               $ 500,000  
Series B Convertible Preferred Stock [Member]                  
Class of Stock [Line Items]                  
Preferred stock, par value (in dollars per share) | $ / shares               $ 0.001 $ 0.001
Preferred stock, shares issued               237,745 0
Preferred stock, shares outstanding               237,745 0
Outstanding common stock at election of purchaser               9.99%  
Number of common shares issued upon conversion               5  
Number of shares converted               5  
Series B Convertible Preferred Stock [Member] | Acorn Bioventures, LP [Member]                  
Class of Stock [Line Items]                  
Warrants to purchase shares   669,854              
Sell of stock, price per share | $ / shares   $ 4.18           $ 4.18  
Effective Conversion price per share | $ / shares               $ 3.18  
Warrants exercisable date   Dec. 18, 2021              
Warrant outstanding Term   5 years              
Proceeds from issuance of stocks/warrants | $ $ 6,900,000                
Number of common shares called by each warrant   0.4              
Warrants, exercise price per share | $ / shares   $ 4.13              
Warrant to purchase each share of our common stock   0.4              
Number of share sold under the sales agreement   237,745