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Stockholders Equity (Narrative) (Details) - USD ($) |  |  |  |  |  |  |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Oct. 01, 2021 | Aug. 12, 2021 | Mar. 12, 2021 | Dec. 22, 2020 | Dec. 18, 2020 | Apr. 24, 2020 | Apr. 21, 2020 | Jul. 31, 2017 | Sep. 30, 2021 | Mar. 31, 2021 | Sep. 30, 2021 | Dec. 31, 2020 | Dec. 31, 2017 | Apr. 14, 2020
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate offering price |  |  |  |  |  |  |  |  | $ 2,955,000 | $ 13,501,000 |  |  |  |
Common stock, par value (in dollars per share) |  |  |  |  |  |  |  |  | $ 0.001 |  | $ 0.001 | $ 0.001 |  | $ 0.001
Preferred stock, par value (in dollars per share) |  |  |  |  |  |  |  |  | $ 0.001 |  | $ 0.001 | $ 0.001 |  |
Number of share sold under the sales agreement |  |  |  |  |  |  |  |  | 563,625 |  | 563,625 |  |  |
Proceeds from issuance of common stock, net of issuance costs |  |  |  |  |  |  |  |  | $ 3,000,000.0 |  | $ 3,000,000.0 |  |  |
Common stock, shares outstanding (in shares) |  |  |  |  |  |  |  |  | 9,797,735 |  | 9,797,735 | 6,246,896 |  |
Subsequent Events [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share sold under the sales agreement | 170,800 |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from issuance of common stock, net of issuance costs | $ 900,000 |  |  |  |  |  |  |  |  |  |  |  |  |
July 2017 - Underwritten Public Offering [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants, exercise price per share |  |  |  |  |  |  |  |  | $ 40.00 |  | $ 40.00 |  |  |
Percentage of outstanding common stock |  |  |  |  |  |  |  |  |  |  | 4.99% |  |  |
Outstanding common stock at election of purchaser |  |  |  |  |  |  |  |  |  |  | 9.99% |  |  |
Warrants outstanding |  |  |  |  |  |  |  |  | 374,525 |  | 374,525 |  |  |
Warrants exercised |  |  |  |  |  |  |  |  | 0 |  | 0 |  |  |
March 2021 Equity Financing [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from issuance of common stock, net of issuance costs |  |  | $ 13,500,000 |  |  |  |  |  |  |  |  |  |  |
Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate offering price |  |  |  |  |  |  |  |  | $ 1,000 | $ 2,000 |  |  |  |
Number of shares issued (in shares) |  |  |  |  |  |  |  |  | 563,625 | 2,078,214 |  |  |  |
Cantor Fitzgerald & Co. [Member] | At Market Issuance [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Selling commissions, percentage |  | 3.00% |  |  |  |  |  |  |  |  |  |  |  |
Cantor Fitzgerald & Co. [Member] | Maximum [Member] | At Market Issuance [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate offering price |  | $ 50,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |
Acorn Bioventures, LP [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase shares |  |  |  |  |  |  |  |  | 669,854 |  | 669,854 |  |  |
Number of share sold under the sales agreement |  |  |  |  | 485,912 |  |  |  |  |  |  |  |  |
Warrant outstanding Term |  |  |  |  |  |  |  |  | 5 years |  | 5 years |  |  |
Warrants, exercise price per share |  |  |  |  |  |  |  |  | $ 4.13 |  | $ 4.13 |  |  |
Warrants exercised |  |  |  |  |  |  |  |  | 0 |  | 0 |  |  |
Co-Placement Agents [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sell of stock, price per share |  |  |  |  |  |  | $ 5.00 |  |  |  |  |  |  |
Proceeds from issuance of stocks/warrants |  |  |  |  |  | $ 18,300,000 |  |  |  |  |  |  |  |
Warrants, exercise price per share |  |  |  |  |  |  |  |  | $ 5.00 |  | $ 5.00 |  |  |
Number of warrant to purchase each share of our common stock |  |  |  |  |  |  |  |  | 1 |  | 1 |  |  |
Warrants outstanding |  |  |  |  |  |  |  |  | 2,190,000 |  | 2,190,000 |  |  |
Warrants exercised |  |  |  |  |  |  |  |  |  |  | 909,000 |  |  |
Co-Placement Agents [Member] | Pre Funded Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share sold under the sales agreement |  |  |  |  |  |  | 2,090,000 |  |  |  |  |  |  |
Sell of stock, price per share |  |  |  |  |  |  | $ 4.999 |  |  |  |  |  |  |
Warrants, exercise price per share |  |  |  |  |  |  | $ 0.001 |  |  |  |  |  |  |
Number of warrant to purchase each share of our common stock |  |  |  |  |  |  | 1 |  |  |  |  |  |  |
Percentage of outstanding common stock |  |  |  |  |  |  | 4.99% |  |  |  |  |  |  |
Outstanding common stock at election of purchaser |  |  |  |  |  |  | 9.99% |  |  |  |  |  |  |
Shares issued on conversion of prefunded warrants |  |  |  |  |  | 2,090,000 |  |  |  |  |  |  |  |
Co-Placement Agents [Member] | Common Stock Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase shares |  |  |  |  |  |  | 4,000,000 |  |  |  |  |  |  |
Warrant outstanding Term |  |  |  |  |  |  | 5 years |  |  |  |  |  |  |
Warrants, exercise price per share |  |  |  |  |  |  | $ 5.00 |  |  |  |  |  |  |
Number of warrant to purchase each share of our common stock |  |  |  |  |  |  | 1 |  |  |  |  |  |  |
Percentage of outstanding common stock |  |  |  |  |  |  |  |  |  |  | 4.99% |  |  |
Outstanding common stock at election of purchaser |  |  |  |  |  |  |  |  |  |  | 9.99% |  |  |
Notice period from the holder to increase the percentage of ownership of outstanding common stock after exercise of warrants |  |  |  |  |  |  |  |  |  |  | 61 days |  |  |
Fractional shares issued |  |  |  |  |  |  |  |  |  |  | 0 |  |  |
Oppenheimer & Co. Inc. [Member] | March 2021 Equity Financing [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share sold under the sales agreement |  |  | 1,807,143 |  |  |  |  |  |  |  |  |  |  |
Sale of stock, number of additional shares issued in transaction |  |  | 271,071 |  |  |  |  |  |  |  |  |  |  |
Share issue price per share |  |  | $ 7.00 |  |  |  |  |  |  |  |  |  |  |
Common Stock [Member] | Co-Placement Agents [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of share sold under the sales agreement |  |  |  |  |  |  | 1,910,000 |  |  |  |  |  |  |
6% Convertible Exchangeable Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, shares issued |  |  |  |  |  |  |  |  | 335,273 |  | 335,273 | 335,273 |  |
Preferred stock, shares outstanding |  |  |  |  |  |  |  |  | 335,273 |  | 335,273 | 335,273 |  |
Share issue price per share |  |  |  |  |  |  |  |  | $ 10.00 |  | $ 10.00 |  |  |
Dividend rate on convertible exchangeable preferred stock (in percent) |  |  |  |  |  |  |  |  |  |  | 6.00% | 6.00% |  |
Liquidation preference (in dollars per share) |  |  |  |  |  |  |  |  | $ 10.00 |  | $ 10.00 |  |  |
Convertible preferred stock, terms of conversion |  |  |  |  |  |  |  |  |  |  | The Company may automatically convert the 6% Preferred Stock into common stock if the per share closing price of the Company’s common stock has exceeded $59,220, which is 150% of the conversion price of the 6% Preferred Stock, for at least 20 trading days during any 30 day trading period, ending within five trading days prior to notice of automatic conversion. |  |  |
Interest rate of Convertible Subordinated Debentures (as a percent) |  |  |  |  |  |  |  |  | 6.00% |  | 6.00% |  |  |
Accrued and unpaid dividends |  |  |  |  |  |  |  |  | $ 50,291 |  | $ 50,291 |  |  |
Redemption price per share (in dollars per share) |  |  |  |  |  |  |  |  | $ 10.00 |  | $ 10.00 |  |  |
Debt principal amount per share, basis for exchange (in dollars per share) |  |  |  |  |  |  |  |  |  |  | $ 10.00 |  |  |
Debt instrument, term |  |  |  |  |  |  |  |  |  |  | 25 years |  |  |
Series A Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, par value (in dollars per share) |  |  |  |  |  |  |  |  | $ 0.001 |  | $ 0.001 | $ 0.001 |  |
Preferred stock, shares issued |  |  |  |  |  |  |  | 8,872 | 264 |  | 264 | 264 |  |
Preferred stock, shares outstanding |  |  |  |  |  |  |  |  | 264 |  | 264 | 264 |  |
Number of common shares issued upon conversion |  |  |  |  |  |  |  | 215,200 |  |  |  |  |  |
Number of shares converted |  |  |  |  |  |  |  |  |  |  | 6,600 |  | 8,608 |
Price per share used to determine number of shares of common stock |  |  |  |  |  |  |  | $ 1,000 |  |  |  |  |  |
Conversion price of convertible preferred stock |  |  |  |  |  |  |  | $ 40.00 |  |  |  |  |  |
Conversion percentage |  |  |  |  |  |  |  | 9.99% |  |  |  |  |  |
Measurement period of consecutive trading days used in determining whether specified triggers are met which would allow the entity to require the conversion of all or part of outstanding preferred stock |  |  |  |  |  |  |  |  |  |  | 30 days |  |  |
Percentage of blocker provision |  |  |  |  |  |  |  | 4.99% |  |  |  |  |  |
Series A Convertible Preferred Stock [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage by which the weighted average price of common stock during the measurement period exceeds the initial conversion price which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted |  |  |  |  |  |  |  |  |  |  | 300.00% |  |  |
Threshold amount of daily trading volume on each trading day during the measurement period which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted |  |  |  |  |  |  |  |  |  |  | $ 500,000 |  |  |
Series B Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, par value (in dollars per share) |  |  |  |  |  |  |  |  | $ 0.001 |  | $ 0.001 | $ 0.001 |  |
Preferred stock, shares issued |  |  |  |  |  |  |  |  | 237,745 |  | 237,745 | 237,745 |  |
Preferred stock, shares outstanding |  |  |  |  |  |  |  |  | 237,745 |  | 237,745 | 237,745 |  |
Sell of stock, price per share |  |  |  |  |  |  |  |  | $ 4.18 |  | $ 4.18 |  |  |
Effective Conversion price per share |  |  |  |  |  |  |  |  |  |  | $ 3.18 |  |  |
Number of common shares issued upon conversion |  |  |  |  |  |  |  |  | 5 |  | 5 |  |  |
Series B Convertible Preferred Stock [Member] | Acorn Bioventures, LP [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase shares |  |  |  |  | 669,854 |  |  |  |  |  |  |  |  |
Number of share sold under the sales agreement |  |  |  |  | 237,745 |  |  |  |  |  |  |  |  |
Sell of stock, price per share |  |  |  |  | $ 4.18 |  |  |  |  |  |  |  |  |
Warrants exercisable date |  |  |  |  | Dec. 18, 2020 |  |  |  |  |  |  |  |  |
Warrant outstanding Term |  |  |  |  | 5 years |  |  |  |  |  |  |  |  |
Proceeds from issuance of stocks/warrants |  |  |  | $ 6,900,000 |  |  |  |  |  |  |  |  |  |
Warrants, exercise price per share |  |  |  |  | $ 4.13 |  |  |  |  |  |  |  |  |
Number of warrant to purchase each share of our common stock |  |  |  |  | 1 |  |  |  |  |  |  |  |  |
Warrants outstanding |  |  |  |  | 400,000 |  |  |  |  |  |  |  |  |

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