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Stockholders Equity (Narrative) (Details)
 1 Months Ended 12 Months Ended
Aug. 12, 2021
USD ($)
Mar. 16, 2021
USD ($)
Mar. 12, 2021
$ / shares
shares
Dec. 22, 2020
USD ($)
Dec. 18, 2020
$ / shares
shares
Apr. 24, 2020
USD ($)
Apr. 21, 2020
$ / shares
shares
Jul. 31, 2017
$ / shares
shares
Dec. 31, 2021
USD ($)
item
$ / shares
shares
Dec. 31, 2020
USD ($)
$ / shares
shares
Class of Stock [Line Items]                    
Aggregate offering price | $                 $ 13,502,000 $ 21,445,000
Common stock, par value (in dollars per share) | $ / shares                 $ 0.001 $ 0.001
Preferred stock, par value (in dollars per share) | $ / shares                 $ 0.001 $ 0.001
Number of share sold under the sales agreement                 752,425  
Proceeds from issuance of common stock, net of issuance costs | $                 $ 4,000,000.0  
Common stock, shares outstanding (in shares)                 9,993,135 6,246,896
July 2017 - Underwritten Public Offering [Member]                    
Class of Stock [Line Items]                    
Warrants, exercise price per share | $ / shares                 $ 40.00  
Warrants outstanding                 374,525  
Warrants exercised                 0 0
Common Stock                    
Class of Stock [Line Items]                    
Aggregate offering price | $                 $ 2,000 $ 4,000
Number of shares issued (in shares)                 2,078,214 4,485,898
Warrant & stock option exercises (in shares)                 909,007 901,000
Cantor Fitzgerald & Co. [Member] | At Market Issuance [Member]                    
Class of Stock [Line Items]                    
Selling commissions, percentage 3.00%                  
Cantor Fitzgerald & Co. [Member] | Maximum | At Market Issuance [Member]                    
Class of Stock [Line Items]                    
Aggregate offering price | $ $ 50,000,000.0                  
Acorn Bioventures, LP [Member]                    
Class of Stock [Line Items]                    
Warrants exercisable date                 Dec. 18, 2020  
Warrant outstanding Term                 5 years  
Warrants, exercise price per share | $ / shares                 $ 4.13  
Warrants outstanding                 669,854  
Proceeds from warrants exercised | $                 $ 4,500,000  
Co-Placement Agents [Member]                    
Class of Stock [Line Items]                    
Sale of stock, price per share | $ / shares             $ 5.00      
Warrant outstanding Term             5 years      
Proceeds from issuance of stocks/warrants | $           $ 18,300,000        
Warrants, exercise price per share | $ / shares             $ 5.00   $ 5.00  
Number of warrant to purchase each share of our common stock                 1  
Warrants outstanding                 2,190,000 3,099,000
Warrants exercised                 909,000  
Co-Placement Agents [Member] | Pre Funded Warrants [Member]                    
Class of Stock [Line Items]                    
Number of share sold under the sales agreement             2,090,000      
Sale of stock, price per share | $ / shares             $ 4.999      
Warrants, exercise price per share | $ / shares             $ 0.001      
Number of warrant to purchase each share of our common stock             1      
Percentage of outstanding common stock             4.99%      
Outstanding common stock at election of purchaser             9.99%      
Shares issued on conversion of prefunded warrants                 2,090,000  
Co-Placement Agents [Member] | Common Stock Warrants                    
Class of Stock [Line Items]                    
Warrants to purchase shares             4,000,000      
Warrants, exercise price per share | $ / shares             $ 5.00      
Number of warrant to purchase each share of our common stock             1      
Oppenheimer & Co. Inc. [Member] | March 2021 Equity Financing [Member]                    
Class of Stock [Line Items]                    
Common stock, par value (in dollars per share) | $ / shares     $ 0.001              
Number of share sold under the sales agreement     1,807,143              
Sale of stock, number of additional shares issued in transaction     271,071              
Proceeds from issuance of common stock, net of issuance costs | $   $ 13,500,000                
Share issue price per share | $ / shares     $ 7.00              
Common Stock | Acorn Bioventures, LP [Member]                    
Class of Stock [Line Items]                    
Common stock, par value (in dollars per share) | $ / shares         $ 0.001          
Number of share sold under the sales agreement         485,912          
Common Stock | Co-Placement Agents [Member]                    
Class of Stock [Line Items]                    
Number of share sold under the sales agreement             1,910,000      
6% convertible exchangeable preferred stock                    
Class of Stock [Line Items]                    
Preferred stock, shares issued                 335,273 335,273
Preferred stock, shares outstanding                 335,273 335,273
Share issue price per share | $ / shares                 $ 10.00 $ 10.00
Number of common shares issued upon conversion                 0.00025  
Share Price | $ / shares                 $ 59,220  
Dividend rate on convertible exchangeable preferred stock (in percent)                 6.00% 6.00%
Liquidation preference (in dollars per share) | $ / shares                 $ 10.00 $ 10.00
Accrued and unpaid dividends in arrears on preferred stock | $                   $ 700,000
Accrued and unpaid dividends in arrears on preferred stock (in dollars per share) | $ / shares                 1.95  
Shares reserved for future issuance upon conversion                   85
Conversion price (in dollars per share) | $ / shares                 $ 39,480  
Percentage of closing sales price of common stock that conversion price must exceed in order for preferred stock to be convertible                 150.00%  
Number of trading days within 30 trading days in which the closing price of common stock must exceed conversion price for preferred stock to be convertible                 20 days  
Number of trading days during which closing price of common stock must exceed conversion price for at least 20 days in order for the preferred stock to be convertible                 30 days  
Number of trading days prior to notice of automatic conversion                 5 days  
Number of quarterly periods in which dividends are not paid that triggers the right of preferred stock holders to nominate and elect directors | item                 6  
Interest rate of Convertible Subordinated Debentures (as a percent)                 6.00%  
Redemption price per share (in dollars per share) | $ / shares                 $ 10.00  
Debt principal amount per share, basis for exchange (in dollars per share) | $ / shares                 $ 10.00  
Debt instrument, term                 25 years  
Series A convertible preferred stock                    
Class of Stock [Line Items]                    
Preferred stock, par value (in dollars per share) | $ / shares                 $ 0.001 $ 0.001
Preferred stock, shares issued               8,872 264 264
Preferred stock, shares outstanding                 264 264
Number of shares converted                 6,600  
Price per share used to determine number of shares of common stock | $ / shares               $ 1,000    
Conversion price of convertible preferred stock | $ / shares               $ 40.00    
Conversion percentage               9.99%    
Measurement period of consecutive trading days used in determining whether specified triggers are met which would allow the entity to require the conversion of all or part of outstanding preferred stock                 30 days  
Percentage of blocker provision               4.99%    
Series A convertible preferred stock | Minimum                    
Class of Stock [Line Items]                    
Percentage by which the weighted average price of common stock during the measurement period exceeds the initial conversion price which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted                 300.00%  
Threshold amount of daily trading volume on each trading day during the measurement period which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted | $                 $ 500,000  
Series B Convertible Preferred Stock                    
Class of Stock [Line Items]                    
Preferred stock, par value (in dollars per share) | $ / shares                 $ 0.001 $ 0.001
Preferred stock, shares issued                 237,745 237,745
Preferred stock, shares outstanding                 237,745 237,745
Outstanding common stock at election of purchaser                 9.99%  
Number of common shares issued upon conversion                 5  
Number of shares converted                 5  
Series B Convertible Preferred Stock | Acorn Bioventures, LP [Member]                    
Class of Stock [Line Items]                    
Common stock, par value (in dollars per share) | $ / shares         $ 0.001          
Warrants to purchase shares         669,854          
Number of share sold under the sales agreement         237,745          
Sale of stock, price per share | $ / shares         $ 4.18       $ 4.18  
Effective Conversion price per share | $ / shares                 $ 3.18  
Warrants exercisable date         Dec. 18, 2020          
Warrant outstanding Term         5 years          
Proceeds from issuance of stocks/warrants | $       $ 6,900,000            
Warrants, exercise price per share | $ / shares         $ 4.13          
Number of warrant to purchase each share of our common stock         0.4