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Stockholders Equity - Narrative (Details) - USD ($)
 1 Months Ended 3 Months Ended 12 Months Ended
Aug. 12, 2021
Mar. 12, 2021
Dec. 22, 2020
Dec. 18, 2020
Apr. 24, 2020
Apr. 21, 2020
May 12, 2022
Jul. 31, 2017
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2021
Dec. 31, 2017
Class of Stock [Line Items]                        
Aggregate offering price                   $ 13,502,000    
Common stock, par value (in dollars per share)                 $ 0.001   $ 0.001  
Preferred stock, par value (in dollars per share)                 $ 0.001   $ 0.001  
Common stock, shares issued                 9,993,135   9,993,135  
March 2021 Equity Financing [Member]                        
Class of Stock [Line Items]                        
Proceeds from issuance of common stock, net of issuance costs   $ 13,500,000                    
July 2017 - Underwritten Public Offering [Member]                        
Class of Stock [Line Items]                        
Warrants, exercise price per share                 $ 40.00      
Percentage Of Outstanding Common Stock                 4.99%      
Outstanding common stock at election of purchaser                 9.99%      
Warrant Exercises (in shares)                 0 0    
Warrants outstanding                 374,525      
Cantor Fitzgerald & Co. [Member]                        
Class of Stock [Line Items]                        
Aggregate offering price $ 10,000,000.0                      
Selling commissions, percentage 3.00%                      
Proceeds from issuance of stocks/warrants             $ 6,000          
Number of shares issued (in shares)             1,854          
Common stock, shares issued                 752,425      
Total gross proceeds received                 $ 4,000,000.0      
Oppenheimer & Co. Inc. [Member] | March 2021 Equity Financing [Member]                        
Class of Stock [Line Items]                        
Common stock, par value (in dollars per share)                 $ 0.001      
Term of overallotment option   30 days                    
Share issue price per share   $ 7.00                    
Sale of stock, number of additional shares issued in transaction   271,071                    
Number of shares issued (in shares)   1,807,143                    
Acorn Bioventures, LP [Member]                        
Class of Stock [Line Items]                        
Number of share sold under the sales agreement       485,912                
Common stock, par value (in dollars per share)       $ 0.001                
Co-Placement Agents [Member]                        
Class of Stock [Line Items]                        
Sale of stock, price per share           $ 5.00            
Warrants, exercise price per share                 $ 5.00      
Proceeds from issuance of stocks/warrants         $ 18,300,000              
Number of common shares called by each warrant                 1      
Warrant Exercises (in shares)                 0 909,000    
Warrants outstanding                 2,190,000      
Fractional shares issued                 0      
Co-Placement Agents [Member] | Pre Funded Warrants [Member]                        
Class of Stock [Line Items]                        
Number of share sold under the sales agreement           2,090,000            
Sale of stock, price per share           $ 4.999            
Warrants, exercise price per share           $ 0.001            
Number of common shares issued upon conversion           1            
Percentage Of Outstanding Common Stock           4.99%            
Outstanding common stock at election of purchaser           9.99%            
Shares issued on conversion of prefunded warrants         2,090,000              
Co-Placement Agents [Member] | Common Stock Warrants                        
Class of Stock [Line Items]                        
Warrants to purchase shares           4,000,000            
Warrant outstanding Term           5 years            
Warrants, exercise price per share           $ 5.00            
Number of common shares issued upon conversion           1            
Percentage Of Outstanding Common Stock                 4.99%      
Outstanding common stock at election of purchaser                 9.99%      
Notice period from the holder to increase the percentage of ownership of outstanding common stock after exercise of warrants                 61 days      
Series B Convertible Preferred Stock                        
Class of Stock [Line Items]                        
Preferred stock, par value (in dollars per share)                 $ 0.001   $ 0.001  
Sale of stock, price per share                 $ 4.18      
Number of common shares issued upon conversion                 5      
Effective Conversion price per share                 $ 3.18      
Preferred stock, shares issued                 237,745   237,745  
Preferred stock, shares outstanding                 237,745   237,745  
Series B Convertible Preferred Stock | Acorn Bioventures, LP [Member]                        
Class of Stock [Line Items]                        
Number of share sold under the sales agreement       237,745                
Preferred stock, par value (in dollars per share)       $ 0.001                
Warrants to purchase shares       669,854         669,854      
Sale of stock, price per share       $ 4.18                
Warrant outstanding Term       5 years         5 years      
Warrants, exercise price per share       $ 4.13         $ 4.13      
Proceeds from issuance of stocks/warrants     $ 6,900,000                  
Number of common shares called by each warrant       0.4                
Warrant Exercises (in shares)                 0 0    
Common Stock | Co-Placement Agents [Member]                        
Class of Stock [Line Items]                        
Number of share sold under the sales agreement           1,910,000            
Series A Convertible Preferred Stock                        
Class of Stock [Line Items]                        
Measurement period of consecutive trading days used in determining whether specified triggers are met which would allow the entity to require the conversion of all or part of outstanding preferred stock                 30 days      
Preferred stock, par value (in dollars per share)                 $ 0.001   $ 0.001  
Number of common shares issued upon conversion                       215,200
Preferred stock, shares issued                 264   264  
Preferred stock, shares outstanding                 264   264  
Number of shares converted                 6,600     8,608
Series A Convertible Preferred Stock | July 2017 - Underwritten Public Offering [Member]                        
Class of Stock [Line Items]                        
Effective Conversion price per share               $ 40.00        
Preferred stock, shares issued               8,872        
Price per share used to determine number of shares of common stock               $ 1,000        
Percentage of blocker provision               4.99%        
Conversion percentage               9.99%        
Series A Convertible Preferred Stock | Minimum                        
Class of Stock [Line Items]                        
Percentage by which the weighted average price of common stock during the measurement period exceeds the initial conversion price which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted                 300.00%      
Threshold amount of daily trading volume on each trading day during the measurement period which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted                 $ 500,000      
6% convertible exchangeable preferred stock                        
Class of Stock [Line Items]                        
Share issue price per share                 $ 10.00      
Preferred stock, shares issued                 335,273   335,273  
Preferred stock, shares outstanding                 335,273   335,273  
Dividend rate on convertible exchangeable preferred stock (in percent)                 6.00%   6.00%  
Accrued and unpaid dividends                 $ 50,291      
Convertible Preferred Stock, Terms of Conversion                 The Company may automatically convert the 6% Preferred Stock into common stock if the per share closing price of the Company’s common stock has exceeded $59,220, which is 150% of the conversion price of the 6% Preferred Stock, for at least 20 trading days during any 30 day trading period, ending within five trading days prior to notice of automatic conversion.      
Redemption price per share (in dollars per share)                 $ 10.00      
Debt principal amount per share, basis for exchange (in dollars per share)                 $ 10.00      
Debt Instrument, Term                 25 years      
Liquidation preference (in dollars per share)                 $ 10.00