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Stockholders Equity - Narrative (Details) - USD ($)
 1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Aug. 12, 2021
Mar. 12, 2021
Dec. 22, 2020
Dec. 18, 2020
Apr. 24, 2020
Apr. 21, 2020
Jul. 31, 2017
Jun. 30, 2022
Jun. 30, 2021
Mar. 31, 2021
Jun. 30, 2022
Jun. 30, 2021
Dec. 31, 2021
Dec. 31, 2017
Class of Stock [Line Items]                            
Aggregate offering price                   $ 13,502,000        
Common stock, par value (in dollars per share)               $ 0.001     $ 0.001   $ 0.001  
Preferred stock, par value (in dollars per share)               $ 0.001     $ 0.001   $ 0.001  
Common stock, shares issued               11,350,289     11,350,289   9,993,135  
March 2021 Equity Financing [Member]                            
Class of Stock [Line Items]                            
Proceeds from issuance of common stock, net of issuance costs   $ 13,500,000                        
July 2017 - Underwritten Public Offering [Member]                            
Class of Stock [Line Items]                            
Warrants, exercise price per share                 $ 40.00     $ 40.00    
Percentage Of Outstanding Common Stock                       4.99%    
Outstanding common stock at election of purchaser                       9.99%    
Warrants outstanding                 374,525     374,525    
Warrants exercised               0 0   0 0    
Cantor Fitzgerald & Co. [Member]                            
Class of Stock [Line Items]                            
Aggregate offering price $ 10,000,000.0                          
Selling commissions, percentage 3.00%                          
Number of share sold under the sales agreement                     2,092,167      
Proceeds from issuance of common stock, net of issuance costs                     $ 5,900,000      
Oppenheimer & Co. Inc. [Member] | March 2021 Equity Financing [Member]                            
Class of Stock [Line Items]                            
Number of share sold under the sales agreement   1,807,143                        
Share issue price per share   $ 7.00                        
Sale of stock, number of additional shares issued in transaction   271,071                        
Acorn Bioventures, LP [Member]                            
Class of Stock [Line Items]                            
Warrants to purchase shares                 669,854     669,854    
Warrant outstanding Term                 5 years     5 years    
Warrants, exercise price per share                 $ 4.13     $ 4.13    
Warrants exercised               0 0   0 0    
Acorn Bioventures, LP [Member] | Common Stock Warrants                            
Class of Stock [Line Items]                            
Number of share sold under the sales agreement       669,854                    
Co-Placement Agents [Member]                            
Class of Stock [Line Items]                            
Sale of stock, price per share           $ 5.00                
Warrants, exercise price per share               $ 5.00     $ 5.00      
Proceeds from issuance of stocks/warrants         $ 18,300,000                  
Number of common shares called by each warrant               1     1      
Warrant Exercises (in shares)               0 909,000   0 909,000    
Warrants outstanding               2,190,000     2,190,000      
Fractional shares issued                     0      
Co-Placement Agents [Member] | Pre Funded Warrants [Member]                            
Class of Stock [Line Items]                            
Number of share sold under the sales agreement           2,090,000                
Sale of stock, price per share           $ 4.999                
Warrants, exercise price per share           $ 0.001                
Number of common shares issued upon conversion           1                
Percentage Of Outstanding Common Stock           4.99%                
Outstanding common stock at election of purchaser           9.99%                
Shares issued on conversion of prefunded warrants         2,090,000                  
Co-Placement Agents [Member] | Common Stock Warrants                            
Class of Stock [Line Items]                            
Warrants to purchase shares           4,000,000                
Warrant outstanding Term           5 years                
Warrants, exercise price per share           $ 5.00                
Number of common shares issued upon conversion           1                
Percentage Of Outstanding Common Stock                     4.99%      
Outstanding common stock at election of purchaser                     9.99%      
Notice period from the holder to increase the percentage of ownership of outstanding common stock after exercise of warrants                     61 days      
Series B Convertible Preferred Stock                            
Class of Stock [Line Items]                            
Preferred stock, par value (in dollars per share)               $ 0.001     $ 0.001   $ 0.001  
Sale of stock, price per share               $ 4.18     $ 4.18      
Number of common shares issued upon conversion               5     5      
Effective Conversion price per share                     $ 3.18      
Preferred stock, shares issued               237,745     237,745   237,745  
Preferred stock, shares outstanding               237,745     237,745   237,745  
Series B Convertible Preferred Stock | Acorn Bioventures, LP [Member]                            
Class of Stock [Line Items]                            
Number of share sold under the sales agreement       237,745                    
Preferred stock, par value (in dollars per share)       $ 0.001                    
Sale of stock, price per share       $ 4.18                    
Warrant outstanding Term       5 years                    
Warrants, exercise price per share       $ 4.13                    
Proceeds from issuance of stocks/warrants     $ 6,900,000                      
Number of common shares called by each warrant       0.4                    
Common Stock | Acorn Bioventures, LP [Member]                            
Class of Stock [Line Items]                            
Number of share sold under the sales agreement       485,912                    
Common stock, par value (in dollars per share)       $ 0.001                    
Common Stock | Co-Placement Agents [Member]                            
Class of Stock [Line Items]                            
Number of share sold under the sales agreement           1,910,000                
Series A Convertible Preferred Stock                            
Class of Stock [Line Items]                            
Measurement period of consecutive trading days used in determining whether specified triggers are met which would allow the entity to require the conversion of all or part of outstanding preferred stock                     30 days      
Preferred stock, par value (in dollars per share)               $ 0.001     $ 0.001   $ 0.001  
Number of common shares issued upon conversion             215,200              
Effective Conversion price per share             $ 40.00              
Preferred stock, shares issued             8,872 264     264   264  
Preferred stock, shares outstanding               264     264   264  
Number of shares converted                     6,600     8,608
Price per share used to determine number of shares of common stock             $ 1,000              
Percentage of blocker provision             4.99%              
Conversion percentage             9.99%              
Series A Convertible Preferred Stock | Minimum                            
Class of Stock [Line Items]                            
Percentage by which the weighted average price of common stock during the measurement period exceeds the initial conversion price which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted                     300.00%      
Threshold amount of daily trading volume on each trading day during the measurement period which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted                     $ 500,000      
6% convertible exchangeable preferred stock                            
Class of Stock [Line Items]                            
Share issue price per share               $ 10.00     $ 10.00      
Preferred stock, shares issued               335,273     335,273   335,273  
Preferred stock, shares outstanding               335,273     335,273   335,273  
Dividend rate on convertible exchangeable preferred stock (in percent)                     6.00%   6.00%  
Accrued and unpaid dividends               $ 50,291     $ 50,291      
Convertible Preferred Stock, Terms of Conversion                     The Company may automatically convert the 6% Preferred Stock into common stock if the per share closing price of the Company’s common stock has exceeded $59,220, which is 150% of the conversion price of the 6% Preferred Stock, for at least 20 trading days during any 30 day trading period, ending within five trading days prior to notice of automatic conversion.      
Redemption price per share (in dollars per share)               $ 10.00     $ 10.00      
Debt principal amount per share, basis for exchange (in dollars per share)                     $ 10.00      
Debt Instrument, Term                     25 years      
Liquidation preference (in dollars per share)               $ 10.00     $ 10.00      
Interest rate of Convertible Subordinated Debentures (as a percent)               6.00%     6.00%