<SEC-DOCUMENT>0001178913-22-000598.txt : 20220214
<SEC-HEADER>0001178913-22-000598.hdr.sgml : 20220214
<ACCEPTANCE-DATETIME>20220214061510
ACCESSION NUMBER:		0001178913-22-000598
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20220214
DATE AS OF CHANGE:		20220214
GROUP MEMBERS:		SPHERA GLOBAL HEALTHCARE GP LTD.
GROUP MEMBERS:		SPHERA GLOBAL HEALTHCARE MANAGEMENT LP
GROUP MEMBERS:		SPHERA HEALTHCARE US INC.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Cyclacel Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001130166
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				911766850
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-80136
		FILM NUMBER:		22624627

	BUSINESS ADDRESS:	
		STREET 1:		200 CONNELL DRIVE
		STREET 2:		SUITE 1500
		CITY:			BERKELEY HEIGHTS
		STATE:			NJ
		ZIP:			07922
		BUSINESS PHONE:		908-517-7330

	MAIL ADDRESS:	
		STREET 1:		200 CONNELL DRIVE
		STREET 2:		SUITE 1500
		CITY:			BERKELEY HEIGHTS
		STATE:			NJ
		ZIP:			07922

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	XCYTE THERAPIES INC
		DATE OF NAME CHANGE:	20001218

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SPHERA FUNDS MANAGEMENT LTD.
		CENTRAL INDEX KEY:			0001496201
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		21 HA'ARBA'AH STREET
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			64739
		BUSINESS PHONE:		972-3-6845535

	MAIL ADDRESS:	
		STREET 1:		21 HA'ARBA'AH STREET
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			64739
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>zk2227288.htm
<DESCRIPTION>SC 13G/A
<TEXT>
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      <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Washington, D.C.&#160; 20549</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SCHEDULE 13G</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;(Amendment No. 1)*</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 16pt; font-weight: bold;"><u>Cyclacel Pharmaceuticals, Inc.</u></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">(Name of Issuer)</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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      <div style="text-align: center; line-height: 1.25;"><u>Common Stock, par value $0.001 per share</u></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;(Title of Class of Securities)</div>
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      <div style="text-align: center; line-height: 1.25;"><u>23254L603</u></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;(CUSIP Number)</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25;">
        <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u>December 31</u><u>, 2021</u></div>
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">(Date of Event Which Requires Filing of this Statement)</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 28.35pt; line-height: 1.25;">&#9744; Rule 13d-1(b)</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 28.35pt; line-height: 1.25;">&#9746; Rule 13d-1(c)</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 28.35pt; line-height: 1.25;">&#9744; Rule 13d-1(d)</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment
        containing information which would alter the disclosures provided in a prior cover page.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">The information required in the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the <font style="font-style: italic;">Securities Exchange Act</font>
        of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
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      <table cellspacing="0" cellpadding="3" border="0" id="ze2c518f301d54a39828e82d4a582f9f2" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

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              <div style="line-height: 1.25; font-weight: bold;">CUSIP No. 23254L603</div>
            </td>
            <td style="width: 33%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">13G</div>
            </td>
            <td style="width: 33%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="line-height: 1.25; font-weight: bold;">Page 2 of 11 Pages</div>
            </td>
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      <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

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              <div style="text-align: center; line-height: 1.25; font-weight: bold;">1</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">NAME OF REPORTING PERSONS</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">Sphera Funds Management Ltd.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">2</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP&#160;&#160; (See instructions)</div>
              <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25;">(a) &#9744;</div>
              <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25;">(b) &#9746;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">3</div>
            </td>
            <td style="background-color: #CCEEFF; border-left: 2px solid #000000; border-right: 2px solid #000000; border-top: 2px solid #000000; vertical-align: top; width: 94.44%;">
              <div style="margin-right: 30pt; line-height: 1.25;">SEC USE ONLY</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">4</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">Israel</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

          <tr>
            <td style="width: 12%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="4">
              <div style="text-align: center; line-height: 1.25;">NUMBER OF</div>
              <div style="text-align: center; line-height: 1.25;">SHARES</div>
              <div style="text-align: center; line-height: 1.25;">BENEFICIALLY</div>
              <div style="text-align: center; line-height: 1.25;">OWNED BY</div>
              <div style="text-align: center; line-height: 1.25;">EACH</div>
              <div style="text-align: center; line-height: 1.25;">REPORTING</div>
              <div style="text-align: center; line-height: 1.25;">PERSON WITH</div>
            </td>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">5</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SOLE VOTING POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">---</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">6</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SHARED VOTING POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">7</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SOLE DISPOSITIVE POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">---</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">8</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SHARED DISPOSITIVE POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
              </div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

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            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">9</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">10</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)</div>
              <div style="margin-right: 30pt; line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;&#9744;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">11</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">5.10% (*) (**)</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">12</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">TYPE OF REPORTING PERSON&#160;&#160; (See instructions)</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">CO</div>
            </td>
          </tr>

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      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">(*) The beneficial ownership of the securities reported herein is described in Item 4(a).</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;">(**) Based on 9,975,135 shares of Common Stock
          outstanding as of November 10, 2021, as provided in the Issuer's Quarterly Report
            on Form 10-Q filed with the Securities and Exchange Commission (the "<u>SEC</u>") on November 12, 2021.</div>
      </div>
      <div style="line-height: 1.25;"> <br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">2</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: right; line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="3" border="0" id="z29515ccf82074d05834d03ea5ac97e96" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

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            <td style="width: 33%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="line-height: 1.25; font-weight: bold;">CUSIP No. 23254L603</div>
            </td>
            <td style="width: 33%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">13G</div>
            </td>
            <td style="width: 33%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="line-height: 1.25; font-weight: bold;">Page 3 of 11 Pages</div>
            </td>
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              <div style="text-align: center; line-height: 1.25; font-weight: bold;">1</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">NAME OF REPORTING PERSONS</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">Sphera Global Healthcare GP Ltd.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">2</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP&#160;&#160; (See instructions)</div>
              <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25;">(a) &#9744;</div>
              <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25;">(b) &#9746;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">3</div>
            </td>
            <td style="background-color: #CCEEFF; border-left: 2px solid #000000; border-right: 2px solid #000000; border-top: 2px solid #000000; vertical-align: top; width: 94.44%;">
              <div style="margin-right: 30pt; line-height: 1.25;">SEC USE ONLY</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">4</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">Israel</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

          <tr>
            <td style="width: 12%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="4">
              <div style="text-align: center; line-height: 1.25;">NUMBER OF</div>
              <div style="text-align: center; line-height: 1.25;">SHARES</div>
              <div style="text-align: center; line-height: 1.25;">BENEFICIALLY</div>
              <div style="text-align: center; line-height: 1.25;">OWNED BY</div>
              <div style="text-align: center; line-height: 1.25;">EACH</div>
              <div style="text-align: center; line-height: 1.25;">REPORTING</div>
              <div style="text-align: center; line-height: 1.25;">PERSON WITH</div>
            </td>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">5</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SOLE VOTING POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">---</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">6</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SHARED VOTING POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">7</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SOLE DISPOSITIVE POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">---</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">8</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SHARED DISPOSITIVE POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
              </div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">9</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">10</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)</div>
              <div style="margin-right: 30pt; line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;&#9744;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">11</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">5.10% (*) (**)</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">12</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">TYPE OF REPORTING PERSON&#160;&#160; (See instructions)</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">CO</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">(*) The beneficial ownership of the securities reported herein is described in Item 4(a).</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;">(**) Based on 9,975,135 shares of Common Stock
          outstanding as of November 10, 2021, as provided in the Issuer's Quarterly Report
            on Form 10-Q filed with the SEC on November 12, 2021.</div>
      </div>
      <div style="text-align: justify; line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">3</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <!--PROfilePageNumberReset%Num%4%%%-->
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="3" border="0" id="z9590c712c99644e5a3803da72cebefb0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

          <tr>
            <td style="width: 33%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="line-height: 1.25; font-weight: bold;">CUSIP No. 23254L603</div>
            </td>
            <td style="width: 33%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">13G</div>
            </td>
            <td style="width: 33%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="line-height: 1.25; font-weight: bold;">Page 4 of 11 Pages</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">1</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">NAME OF REPORTING PERSONS</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">Sphera Global Healthcare Management LP</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">2</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP&#160;&#160; (See instructions)</div>
              <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25;">(a) &#9744;</div>
              <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25;">(b) &#9746;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">3</div>
            </td>
            <td style="background-color: #CCEEFF; border-left: 2px solid #000000; border-right: 2px solid #000000; border-top: 2px solid #000000; vertical-align: top; width: 94.44%;">
              <div style="margin-right: 30pt; line-height: 1.25;">SEC USE ONLY</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">4</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">Israel</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

          <tr>
            <td style="width: 12%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="4">
              <div style="text-align: center; line-height: 1.25;">NUMBER OF</div>
              <div style="text-align: center; line-height: 1.25;">SHARES</div>
              <div style="text-align: center; line-height: 1.25;">BENEFICIALLY</div>
              <div style="text-align: center; line-height: 1.25;">OWNED BY</div>
              <div style="text-align: center; line-height: 1.25;">EACH</div>
              <div style="text-align: center; line-height: 1.25;">REPORTING</div>
              <div style="text-align: center; line-height: 1.25;">PERSON WITH</div>
            </td>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">5</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SOLE VOTING POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">---</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">6</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SHARED VOTING POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">7</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SOLE DISPOSITIVE POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">---</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">8</div>
            </td>
            <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">SHARED DISPOSITIVE POWER</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
              </div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">9</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">10</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)</div>
              <div style="margin-right: 30pt; line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;&#9744;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">11</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">5.10% (*) (**)</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">12</div>
            </td>
            <td style="width: 94.44%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
              <div style="margin-right: 30pt; line-height: 1.25;">TYPE OF REPORTING PERSON (See instructions)</div>
              <div style="line-height: 1.25; text-align: right;"><font style="line-height: 1.25;">&#160;</font></div>
              <div style="margin-right: 30pt; line-height: 1.25;">CO</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">(*) The beneficial ownership of the securities reported herein is described in Item 4(a).</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;">(**) Based on 9,975,135 shares of Common Stock
          outstanding as of November 10, 2021, as provided in the Issuer's Quarterly Report
            on Form 10-Q filed with the SEC on November 12, 2021.</div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">4</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

            <tr>
              <td style="width: 33%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="line-height: 1.25; font-weight: bold;">CUSIP No. 23254L603</div>
              </td>
              <td style="width: 33%; vertical-align: top; border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">13G</div>
              </td>
              <td style="width: 33%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="line-height: 1.25; font-weight: bold;">Page 5 of 11 Pages</div>
              </td>
            </tr>

        </table>
        <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

            <tr>
              <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">1</div>
              </td>
              <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="margin-right: 30pt; line-height: 1.25;">NAME OF REPORTING PERSONS</div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
                <div style="margin-right: 30pt; line-height: 1.25;">
                  <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Sphera Healthcare US Inc.</div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">2</div>
              </td>
              <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="margin-right: 30pt; line-height: 1.25;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP&#160;&#160; (See instructions)</div>
                <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25;">(a) &#9744;</div>
                <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25;">(b) &#9746;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">3</div>
              </td>
              <td style="background-color: #CCEEFF; border-left: 2px solid #000000; border-right: 2px solid #000000; border-top: 2px solid #000000; vertical-align: top; width: 94.44%;">
                <div style="margin-right: 30pt; line-height: 1.25;">SEC USE ONLY</div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              </td>
            </tr>
            <tr>
              <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">4</div>
              </td>
              <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="margin-right: 30pt; line-height: 1.25;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
                <div style="margin-right: 30pt; line-height: 1.25;">Israel</div>
              </td>
            </tr>

        </table>
        <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

            <tr>
              <td style="width: 12%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" rowspan="4">
                <div style="text-align: center; line-height: 1.25;">NUMBER OF</div>
                <div style="text-align: center; line-height: 1.25;">SHARES</div>
                <div style="text-align: center; line-height: 1.25;">BENEFICIALLY</div>
                <div style="text-align: center; line-height: 1.25;">OWNED BY</div>
                <div style="text-align: center; line-height: 1.25;">EACH</div>
                <div style="text-align: center; line-height: 1.25;">REPORTING</div>
                <div style="text-align: center; line-height: 1.25;">PERSON WITH</div>
              </td>
              <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">5</div>
              </td>
              <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="margin-right: 30pt; line-height: 1.25;">SOLE VOTING POWER</div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
                <div style="margin-right: 30pt; line-height: 1.25;">---</div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">6</div>
              </td>
              <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="margin-right: 30pt; line-height: 1.25;">SHARED VOTING POWER</div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
                <div style="margin-right: 30pt; line-height: 1.25;">
                  <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">7</div>
              </td>
              <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="margin-right: 30pt; line-height: 1.25;">SOLE DISPOSITIVE POWER</div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
                <div style="margin-right: 30pt; line-height: 1.25;">---</div>
              </td>
            </tr>
            <tr>
              <td style="width: 6%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">8</div>
              </td>
              <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="margin-right: 30pt; line-height: 1.25;">SHARED DISPOSITIVE POWER</div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
                <div style="margin-right: 30pt; line-height: 1.25;">
                  <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
                </div>
              </td>
            </tr>

        </table>
        <table cellspacing="0" cellpadding="3" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

            <tr>
              <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">9</div>
              </td>
              <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="margin-right: 30pt; line-height: 1.25;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
                <div style="margin-right: 30pt; line-height: 1.25;">
                  <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">508,322 (*)</div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">10</div>
              </td>
              <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="margin-right: 30pt; line-height: 1.25;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)</div>
                <div style="margin-right: 30pt; line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;&#9744;</font></div>
              </td>
            </tr>
            <tr>
              <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">11</div>
              </td>
              <td style="width: 94.44%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
                <div style="margin-right: 30pt; line-height: 1.25;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
                <div style="margin-right: 30pt; line-height: 1.25;">
                  <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">5.10% (*) (**)</div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 5.56%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">12</div>
              </td>
              <td style="width: 94.44%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
                <div style="margin-right: 30pt; line-height: 1.25;">TYPE OF REPORTING PERSON (See instructions)</div>
                <div style="line-height: 1.25; text-align: right;"><font style="line-height: 1.25;">&#160;</font></div>
                <div style="margin-right: 30pt; line-height: 1.25;">CO</div>
              </td>
            </tr>

        </table>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="line-height: 1.25;">(*) The beneficial ownership of the securities reported herein is described in Item 4(a).</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="line-height: 1.25;">(**) Based on 9,975,135 shares of Common Stock outstanding as of November 10, 2021, as provided in the Issuer's Quarterly Report on
          Form 10-Q filed with the SEC on November 12, 2021.</div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal; font-family: 'Times New Roman',Times,serif;">5</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="ea8e87b20ac3496f8284c6771fb27943" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45.8pt;"><font style="font-weight: bold;">Item 1.</font> <br>
            </td>
            <td style="width: 32.2pt; vertical-align: top; align: right;">(a)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Name of Issuer</u>:</div>
            </td>
          </tr>

      </table>
      <div style="text-indent: 28.35pt; margin-left: 49.65pt; line-height: 1.25;"> <br>
      </div>
      <div style="text-indent: 28.35pt; margin-left: 49.65pt; line-height: 1.25;">Cyclacel Pharmaceuticals, Inc.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="ed35cce533cf4fa7920e741d4c3ddbb3" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45.8pt;"></td>
            <td style="width: 32.2pt; vertical-align: top; align: right;">(b)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Address of Issuer's Principal Executive Offices</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 28.35pt; margin-left: 49.65pt; line-height: 1.25;">200 Connell Drive, Suite&#160;1500, Berkeley Heights, New Jersey 07922</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" class="DSPFListTable" id="cfebae2a226c4cd7badc92912d8bd553" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45.8pt;"><font style="font-weight: bold;">Item 2.</font> <br>
            </td>
            <td style="width: 32.2pt; vertical-align: top; align: right;">(a)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Name of Person Filing</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;">Sphera Funds Management Ltd.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;">Sphera Global Healthcare GP Ltd.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;">Sphera Global Healthcare Management LP</div>
      <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;"> <br>
      </div>
      <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;">
        <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Sphera Healthcare US Inc.</div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z799d9a218305400699cafd0ca732c827" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45.8pt;"><br>
            </td>
            <td style="width: 32.2pt; vertical-align: top; align: right;">(b)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Address of Principal Business Office</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">Sphera Funds Management Ltd. &#8211; 21 Ha'arba'ah Street, Tel Aviv 64739, Israel</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare GP Ltd. &#8211; 21 Ha'arba'ah Street, Tel Aviv 64739, Israel</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare Management LP &#8211; 21 Ha'arba'ah Street, Tel Aviv 64739, Israel</div>
      <div style="margin-left: 78pt; line-height: 1.25;"> <br>
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">
        <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Sphera Healthcare US Inc. &#8211;10 East 53rd Street, Suite 1301, New York, NY 10022</div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z89543361b8504532bb75419125f2c709" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45.8pt;"><br>
            </td>
            <td style="width: 32.2pt; vertical-align: top; align: right;">(c)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Citizenship</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">Sphera Funds Management Ltd. &#8211; Israel</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare GP Ltd. &#8211; Israel</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare Management LP &#8211; Israel</div>
      <div style="margin-left: 78pt; line-height: 1.25;"> <br>
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">
        <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Sphera Healthcare US Inc. &#8211; U.S.</div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="zf0898085b8944f9c8f00bf7c65f16969" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45.8pt;"><br>
            </td>
            <td style="width: 32.2pt; vertical-align: top; align: right;">(d)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Title of Class of Securities</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 28.35pt; margin-left: 49.65pt; line-height: 1.25;">Common Stock, par value $0.001 per share</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z6106058c38a54e238c588f01ff00522f" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45.75pt;"><br>
            </td>
            <td style="width: 32.25pt; vertical-align: top; align: right;">(e)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>CUSIP Number</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 28.35pt; margin-left: 49.65pt; line-height: 1.25;">23254L603</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="za4aef95208d04079a3b97d1882c31705" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 3</font>.</td>
            <td style="width: auto; vertical-align: top;">
              <div>Not applicable.</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal; font-family: 'Times New Roman',Times,serif;">6</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="zb16d45617f3547be9013fa6487e89c5a" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 4</font>.</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Ownership</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="zadb680c0cb1543928fc5b969bb200a8c" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 42.55pt;"><br>
            </td>
            <td style="width: 35.45pt; vertical-align: top; align: right;">(a)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Amount beneficially owned</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">See row 9 of cover page of each reporting person.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">
        <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">The securities reported herein by Sphera Funds Management Ltd., Sphera Global Healthcare GP Ltd., Sphera Global Healthcare
          Management LP and Sphera Healthcare US Inc. are beneficially owned as follows:</div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <table cellspacing="0" cellpadding="0" id="z2e4602218adf4de2acc88269cbd5a2c3" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 77.95pt;"><br>
              </td>
              <td style="width: 21.25pt; vertical-align: top; align: right;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div>282,298 shares of Common Stock, representing a total of 2.83% of the total shares of Common Stock outstanding, are held directly by Sphera Global Healthcare Master Fund, which has delegated its investment management authority to
                  Sphera Healthcare US Inc. (the "<u>Management Company</u>").</div>
              </td>
            </tr>

        </table>
        <div style="line-height: 1.25">&#160;</div>
        <table cellspacing="0" cellpadding="0" id="z06a79d99a9be417d97c0ddb09bf40a2e" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 78pt;"><br>
              </td>
              <td style="width: 21.25pt; vertical-align: top; align: right;">&#8226;</td>
              <td style="width: auto; vertical-align: top; text-align: justify;">
                <div>226,024 shares of Common Stock, representing a total of 2.27% of the total shares of Common Stock outstanding, are held directly by Sphera Biotech Master Fund, L.P., which has delegated its investment management
                  authority to the Management Company.</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">
        <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">The Management Company is wholly owned
            by Sphera Global Healthcare Management L.P., which is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd., the
            shares of which are owned 90% by Sphera Funds Management Ltd.</div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; margin-left: 78pt; line-height: 1.25;">This Statement shall not be construed as an admission by any of the Reporting Persons that it is the beneficial owner of any of the securities covered by this Statement, and each
        Reporting Person disclaims beneficial ownership of any such securities.&#160;In addition, the Reporting Persons and other entities named in this Schedule 13G may be deemed to constitute a "group" for purposes of Section 13(d) of the Securities Exchange
        Act of 1934. Neither the filing of this Schedule 13G nor any of its contents shall be deemed to constitute an admission that a group exists for purposes of Section 13(d) of the Securities Exchange Act of 1934 or for any other purpose, and each of
        the Reporting Persons and other entities named in this Schedule 13G disclaims the existence of any such group.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z199e75924e12470a835be944aa4bbf04" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 42.55pt;"><br>
            </td>
            <td style="width: 35.25pt; vertical-align: top; align: right;">(b)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Percent of class</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">See row 11 of cover page of each reporting person</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="zac9004c7bdd64b24899c027ba27c0b00" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 42.55pt;"><br>
            </td>
            <td style="width: 35.45pt; vertical-align: top; align: right;">(c)</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Number of shares as to which such person has</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z03b188c1189049e2b714265f4b265b75" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 77.8pt;"><br>
            </td>
            <td style="width: 28.55pt; vertical-align: top; align: right;">(i)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Sole power to vote or to direct the vote:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 106.35pt; line-height: 1.25;">See row 5 of cover page of each reporting person</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z9a8b1b22811d43479bf7d37b54cd3cfe" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 77.8pt;"><br>
            </td>
            <td style="width: 28.55pt; vertical-align: top; align: right;">(ii)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Shared power to vote or to direct the vote:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 106.35pt; line-height: 1.25;">See row 6 of cover page of each reporting person and note in Item 4(a) above</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z903586380cbe451f8f77be3c503321b5" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 77.8pt;"><br>
            </td>
            <td style="width: 28.55pt; vertical-align: top; align: right;">(iii)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Sole power to dispose or to direct the disposition of:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 106.35pt; line-height: 1.25;">See row 7 of cover page of each reporting person</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z4fff9d0d2817482bbe5b2beb3e13b513" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 77.8pt;"><br>
            </td>
            <td style="width: 28.55pt; vertical-align: top; align: right;">(iv)</td>
            <td style="width: auto; vertical-align: top;">
              <div>Shared power to dispose or to direct the disposition of:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 106.35pt; line-height: 1.25;">See row 8 of cover page of each reporting person and note in Item 4(a) above</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal; font-family: 'Times New Roman',Times,serif;">7</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <table cellspacing="0" cellpadding="0" id="z1b6bd3ddae29444db076e92b75671b20" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 5</font>.</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Ownership of Five Percent or Less of a Class</u>:</div>
            </td>
          </tr>

      </table>
      <div style="text-indent: -78pt; margin-left: 78pt; line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z5bbd69c6912842868b4a7e89425100e6" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 6</font>.</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Ownership of More than Five Percent on Behalf of Another</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z221282e7d9e14f5a9c13d7b50dd03aa3" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 7</font>.</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="zc7d997b19bf04febababe9b185033d27" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 8</font>.</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Identification and Classification of Members of the Group</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z26de42b4c91e4625a503364f1a48421b" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 9</font>.</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Notice of Dissolution of Group</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal; font-family: 'Times New Roman',Times,serif;">8</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <table cellspacing="0" cellpadding="0" id="z56936b9ff3384bafbe2ebd28bc9c8bcd" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 78pt; vertical-align: top; align: right; font-weight: bold;">Item 10.</td>
            <td style="width: auto; vertical-align: top;">
              <div><u>Certification</u>:</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; text-indent: 35.45pt; line-height: 1.25;">By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the
        effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.</div>
      <div style="text-align: justify; text-indent: 35.45pt; line-height: 1.25;"> <br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal; font-family: 'Times New Roman',Times,serif;">9</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: center; line-height: 1.25;">&#160;<font style="font-weight: bold;">SIGNATURE</font></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 35.45pt; line-height: 1.25;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;">February 10, 2022</div>
      </div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="line-height: 1.25">
        <table cellspacing="0" cellpadding="0" border="0" id="z39753a0e095d42ddbd43ba3e5870f179" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">Sphera Funds Management Ltd.</div>
              </td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
              <td style="width: 30%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-style: italic;"><br>
                </div>
                <div style="line-height: 1.25; font-style: normal;">/s/ Neomi Elpeleg</div>
              </td>
              <td style="width: 20%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">By: Neomi Elpeleg</div>
              </td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top;">
                <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Title: Chief Financial Officer</div>
              </td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>

        </table>
        <div style="margin-left: 205.55pt; line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <table cellspacing="0" cellpadding="0" border="0" id="zb0ab1562c57242faa68bbee81fdd87f3" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top;">
                <div style="line-height: 1.25; font-weight: bold;">Sphera Global Healthcare GP Ltd.</div>
              </td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top; border-bottom: 2px solid black;">
                <div style="line-height: 1.25; font-style: italic;"><br>
                </div>
                <div style="line-height: 1.25; font-style: italic;">
                  <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-style: normal;">/s/ Neomi Elpeleg</div>
                </div>
              </td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top;">
                <div style="line-height: 1.25;">By: Neomi Elpeleg</div>
              </td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top;">
                <div style="line-height: 1.25;">Title: Chief Financial Officer</div>
              </td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top;">&#160;</td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top;">
                <div style="line-height: 1.25; font-weight: bold;">Sphera Global Healthcare Management LP</div>
              </td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top; border-bottom: 2px solid black;">
                <div style="line-height: 1.25; font-style: italic;"><br>
                </div>
                <div style="line-height: 1.25; font-style: italic;">
                  <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-style: normal;">/s/ Neomi Elpeleg</div>
                </div>
              </td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top;">
                <div style="line-height: 1.25;">By: Neomi Elpeleg</div>
              </td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top;">
                <div style="line-height: 1.25;">Title: Chief Financial Officer</div>
              </td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 30%; vertical-align: top;">&#160;</td>
              <td style="width: 20%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
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        <div style="text-align: justify; text-indent: 27pt; line-height: 1.25;">Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that only one statement containing the information required by
          Schedule 13G need be filed with respect to the ownership by each of the undersigned of shares of Cyclacel Pharmaceuticals, Inc.; each of them is responsible for the timely filing of such Schedule 13G and any amendments thereto, and for the
          completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the information concerning the other persons making the filing, unless such person knows or
          has reason to believe that such information is inaccurate.&#160;In accordance with Rule 13d-1(k)(1), the undersigned hereby agree to the joint filing with each other on behalf of each of them of such a statement on Schedule 13G and any amendments
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          <div style="line-height: 1.25;">February 10, 2022</div>
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