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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021
Operating activities: |  |
Net loss | $ (21,198) | $ (18,457)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 32 | 43
Stock-based compensation | 1,506 | 1,157
Changes in lease liability | 40 | 172
Changes in operating assets and liabilities: |  |
Prepaid expenses and other assets | (3,784) | (4,480)
Accounts payable, accrued and other current liabilities | 2,577 | 3,025
Net cash used in operating activities | (20,827) | (18,540)
Investing activities: |  |
Purchase of property, plant and equipment | (7) | (27)
Net cash used in investing activities | (7) | (27)
Financing activities: |  |
Proceeds, net of issuance costs, from issuing common stock and warrants | 3,199 | 17,371
Proceeds from the exercise of stock options and warrants, net of issuance costs |  | 4,567
Payment of preferred stock dividend | (201) | (201)
Net cash provided by financing activities | 2,998 | 21,737
Effect of exchange rate changes on cash and cash equivalents | (378) | (17)
Net (decrease) increase in cash and cash equivalents | (18,214) | 3,153
Cash and cash equivalents, beginning of period | 36,559 | 33,406
Cash and cash equivalents, end of period | 18,345 | 36,559
Supplemental cash flow information: |  |
Interest | 211 | 17
Research & Development Tax Credits | 3,312 | 1,358
Non cash financing activities: |  |
Accrual of preferred stock dividends | 50 | $ 50
Deemed dividend on redeemable common stock | $ 135 |

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- Definition Proceeds from issuance of capital stock which provides for a specific dividend that is paid to the shareholders before any dividends to common stockholder, which takes precedence over common stockholders in the event of liquidation and from issuance of rights to purchase common shares at a predetermined price. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3255-108585 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3602-108585 + Details
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- References No definition available. + Details
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