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Stockholders Equity (Narrative) (Details)
 1 Months Ended 12 Months Ended
Aug. 15, 2022
USD ($)
shares
Aug. 12, 2022
USD ($)
shares
Aug. 12, 2021
USD ($)
Mar. 16, 2021
USD ($)
Mar. 12, 2021
$ / shares
shares
Jul. 31, 2017
$ / shares
shares
Dec. 31, 2022
USD ($)
item
$ / shares
shares
Dec. 31, 2021
USD ($)
$ / shares
shares
Class of Stock [Line Items]                
Aggregate offering price | $               $ 13,502,000
Common stock, par value (in dollars per share) | $ / shares             $ 0.001 $ 0.001
Preferred stock, par value (in dollars per share) | $ / shares             $ 0.001 $ 0.001
Common stock, shares outstanding (in shares)             9,422,089 9,993,135
Warrant & stock option exercises (in shares)             0 6,600
July 2017 - Underwritten Public Offering [Member]                
Class of Stock [Line Items]                
Warrant Exercises (in shares)               909,000
Warrants, exercise price per share | $ / shares             $ 40.00  
Percentage of outstanding common stock             4.99%  
Outstanding common stock at election of purchaser             9.99%  
Warrants outstanding             374,525  
Warrants exercised             0 0
Common Stock                
Class of Stock [Line Items]                
Aggregate offering price | $               $ 2,000
Number of shares issued (in shares)               2,078,214
Warrant & stock option exercises (in shares)               915,600
Cantor Fitzgerald & Co. [Member]                
Class of Stock [Line Items]                
Aggregate offering price | $     $ 50,000,000.0          
Number of share sold under the sales agreement 3,281,067           2,528,642  
Proceeds from issuance of common stock, gross | $ $ 7,600,000           $ 3,400,000  
Cantor Fitzgerald & Co. [Member] | August 2021 Controlled Equity Offering Sales Agreement [Member]                
Class of Stock [Line Items]                
Number of share sold under the sales agreement   1,987,100            
Total gross proceeds received | $   $ 2,721,187            
Acorn Bioventures, LP [Member]                
Class of Stock [Line Items]                
Warrants to purchase shares             669,854  
Warrant outstanding Term             5 years  
Warrants, exercise price per share | $ / shares             $ 4.13  
Warrants exercised             0 0
Co-Placement Agents [Member]                
Class of Stock [Line Items]                
Warrants, exercise price per share | $ / shares             $ 5.00  
Number of warrant to purchase each share of our common stock             1  
Warrants outstanding             2,190,000  
Fractional shares issued             0  
Co-Placement Agents [Member] | Common Stock Warrants                
Class of Stock [Line Items]                
Percentage of outstanding common stock             4.99%  
Outstanding common stock at election of purchaser             9.99%  
Notice period from the holder to increase the percentage of ownership of outstanding common stock after exercise of warrants             61 days  
Oppenheimer & Co. Inc. [Member] | March 2021 Equity Financing [Member]                
Class of Stock [Line Items]                
Common stock, par value (in dollars per share) | $ / shares         $ 0.001      
Number of share sold under the sales agreement         1,807,143      
Sale of stock, number of additional shares issued in transaction         271,071      
Proceeds from issuance of common stock, net of issuance costs | $       $ 13,500,000        
Share issue price per share | $ / shares         $ 7.00      
6% convertible exchangeable preferred stock                
Class of Stock [Line Items]                
Preferred stock, shares issued             335,273 335,273
Preferred stock, shares outstanding             335,273 335,273
Share issue price per share | $ / shares             $ 10.00  
Number of common shares issued upon conversion             0.00025  
Share Price | $ / shares             $ 59,220  
Dividend rate on convertible exchangeable preferred stock (in percent)             6.00% 6.00%
Liquidation preference (in dollars per share) | $ / shares             $ 10.00  
Accrued and unpaid dividends in arrears on preferred stock | $             $ 700,000  
Accrued and unpaid dividends in arrears on preferred stock (in dollars per share) | $ / shares             $ 1.95  
Shares reserved for future issuance upon conversion             85  
Conversion price (in dollars per share) | $ / shares             $ 39,480  
Percentage of closing sales price of common stock that conversion price must exceed in order for preferred stock to be convertible             150.00%  
Number of trading days within 30 trading days in which the closing price of common stock must exceed conversion price for preferred stock to be convertible             20 days  
Number of trading days during which closing price of common stock must exceed conversion price for at least 20 days in order for the preferred stock to be convertible             30 days  
Number of trading days prior to notice of automatic conversion             5 days  
Number of quarterly periods in which dividends are not paid that triggers the right of preferred stock holders to nominate and elect directors | item             6  
Interest rate of Convertible Subordinated Debentures (as a percent)             6.00%  
Redemption price per share (in dollars per share) | $ / shares             $ 10.00  
Debt principal amount per share, basis for exchange (in dollars per share) | $ / shares             $ 10.00  
Debt instrument, term             25 years  
Series A Convertible Preferred Stock                
Class of Stock [Line Items]                
Preferred stock, par value (in dollars per share) | $ / shares             $ 0.001 $ 0.001
Preferred stock, shares issued           8,872 264 264
Preferred stock, shares outstanding             264 264
Number of shares converted             6,600  
Price per share used to determine number of shares of common stock | $ / shares           $ 1,000    
Conversion price of convertible preferred stock | $ / shares           $ 40.00    
Conversion percentage           9.99%    
Measurement period of consecutive trading days used in determining whether specified triggers are met which would allow the entity to require the conversion of all or part of outstanding preferred stock             30 days  
Percentage of blocker provision           4.99%    
Series A Convertible Preferred Stock | Minimum                
Class of Stock [Line Items]                
Percentage by which the weighted average price of common stock during the measurement period exceeds the initial conversion price which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted             300.00%  
Threshold amount of daily trading volume on each trading day during the measurement period which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted | $             $ 500,000  
Series B Convertible Preferred Stock                
Class of Stock [Line Items]                
Preferred stock, par value (in dollars per share) | $ / shares             $ 0.001 $ 0.001
Preferred stock, shares issued             237,745 237,745
Preferred stock, shares outstanding             237,745 237,745
Outstanding common stock at election of purchaser             9.99%  
Number of shares converted             5