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Stockholders Equity - Narrative (Details) - USD ($) |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | ---
Aug. 15, 2022 | Aug. 12, 2022 | Aug. 12, 2021 | Jul. 31, 2017 | Mar. 31, 2023 | Mar. 31, 2022 | Dec. 31, 2022 | Dec. 31, 2017
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) |  |  |  |  | $ 0.001 |  | $ 0.001 |
Preferred stock, par value (in dollars per share) |  |  |  |  | $ 0.001 |  | $ 0.001 |
Common stock, shares issued |  |  |  |  | 12,539,189 |  | 12,539,189 |
July 2017 - Underwritten Public Offering [Member] |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Warrants, exercise price per share |  |  |  |  | $ 40.00 |  |  |
Percentage Of Outstanding Common Stock |  |  |  |  | 4.99% |  |  |
Outstanding common stock at election of purchaser |  |  |  |  | 9.99% |  |  |
Warrant Exercises (in shares) |  |  |  |  | 0 | 0 |  |
Warrants outstanding |  |  |  |  | 374,525 |  |  |
Cantor Fitzgerald & Co. [Member] |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Aggregate offering price |  |  | $ 10,000,000.0 |  |  |  |  |
Number of share sold under the sales agreement | 3,281,067 |  |  |  |  |  |  |
Total gross proceeds received | $ 7,600,000 |  |  |  |  |  |  |
Cantor Fitzgerald & Co. [Member] | August 2021 Controlled Equity Offering Sales Agreement [Member] |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Number of share sold under the sales agreement |  | 3,117,100 |  |  |  |  |  |
Total gross proceeds received |  | $ 4,494,496 |  |  |  |  |  |
Aggregate purchase price |  | $ 4,494,496 |  |  |  |  |  |
Reclassified shares |  | 3,117,100 |  |  |  |  |  |
Acorn Bioventures, LP [Member] |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Warrants to purchase shares |  |  |  |  | 669,854 |  |  |
Warrant outstanding Term |  |  |  |  | 5 years |  |  |
Warrants, exercise price per share |  |  |  |  | $ 4.13 |  |  |
Warrant Exercises (in shares) |  |  |  |  | 0 | 0 |  |
Co-Placement Agents [Member] |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Warrants, exercise price per share |  |  |  |  | $ 5.00 |  |  |
Number of common shares called by each warrant |  |  |  |  | 1 |  |  |
Warrant Exercises (in shares) |  |  |  |  | 0 |  |  |
Warrants outstanding |  |  |  |  | 2,190,000 |  |  |
Co-Placement Agents [Member] | Common Stock Warrants |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Percentage Of Outstanding Common Stock |  |  |  |  | 4.99% |  |  |
Outstanding common stock at election of purchaser |  |  |  |  | 9.99% |  |  |
Notice period from the holder to increase the percentage of ownership of outstanding common stock after exercise of warrants |  |  |  |  | 61 days |  |  |
Fractional shares issued |  |  |  |  | 0 |  |  |
Series B Convertible Preferred Stock |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Preferred stock, par value (in dollars per share) |  |  |  |  | $ 0.001 |  | $ 0.001 |
Preferred stock, shares issued |  |  |  |  | 237,745 |  | 237,745 |
Preferred stock, shares outstanding |  |  |  |  | 237,745 |  | 237,745 |
Outstanding common stock at election of purchaser |  |  |  |  | 9.99% |  |  |
Number of shares converted |  |  |  |  | 5 |  |  |
Series A Convertible Preferred Stock |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Measurement period of consecutive trading days used in determining whether specified triggers are met which would allow the entity to require the conversion of all or part of outstanding preferred stock |  |  |  |  | 30 days |  |  |
Preferred stock, par value (in dollars per share) |  |  |  |  | $ 0.001 |  | $ 0.001 |
Number of common shares issued upon conversion |  |  |  |  |  |  |  | 215,200
Preferred stock, shares issued |  |  |  |  | 264 |  | 264 |
Preferred stock, shares outstanding |  |  |  |  | 264 |  | 264 |
Number of shares converted |  |  |  |  | 6,600 |  |  | 8,608
Series A Convertible Preferred Stock | July 2017 - Underwritten Public Offering [Member] |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Effective Conversion price per share |  |  |  | $ 40.00 |  |  |  |
Preferred stock, shares issued |  |  |  | 8,872 |  |  |  |
Price per share used to determine number of shares of common stock |  |  |  | $ 1,000 |  |  |  |
Percentage of blocker provision |  |  |  | 4.99% |  |  |  |
Conversion percentage |  |  |  | 9.99% |  |  |  |
Series A Convertible Preferred Stock | Minimum |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Percentage by which the weighted average price of common stock during the measurement period exceeds the initial conversion price which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted |  |  |  |  | 300.00% |  |  |
Threshold amount of daily trading volume on each trading day during the measurement period which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted |  |  |  |  | $ 500,000 |  |  |
6% convertible exchangeable preferred stock |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |
Share issue price per share |  |  |  |  | $ 10.00 |  |  |
Preferred stock, shares issued |  |  |  |  | 335,273 |  | 335,273 |
Preferred stock, shares outstanding |  |  |  |  | 335,273 |  | 335,273 |
Dividend rate on convertible exchangeable preferred stock (in percent) |  |  |  |  | 6.00% |  | 6.00% |
Accrued and unpaid dividends |  |  |  |  | $ 50,291 |  |  |
Convertible Preferred Stock, Terms of Conversion |  |  |  |  | The Company may automatically convert the 6% Preferred Stock into common stock if the per share closing price of the Company’s common stock has exceeded $59,220, which is 150% of the conversion price of the 6% Preferred Stock, for at least 20 trading days during any 30 day trading period, ending within five trading days prior to notice of automatic conversion. |  |  |
Redemption price per share (in dollars per share) |  |  |  |  | $ 10.00 |  |  |
Debt principal amount per share, basis for exchange (in dollars per share) |  |  |  |  | $ 10.00 |  |  |
Debt Instrument, Term |  |  |  |  | 25 years |  |  |
Liquidation preference (in dollars per share) |  |  |  |  | $ 10.00 |  |  |

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