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Stockholders Equity - Narrative (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Aug. 15, 2022
Aug. 12, 2022
Aug. 12, 2021
Jul. 31, 2017
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2022
Dec. 31, 2017
Class of Stock [Line Items]                
Common stock, par value (in dollars per share)         $ 0.001   $ 0.001  
Preferred stock, par value (in dollars per share)         $ 0.001   $ 0.001  
Common stock, shares issued         12,539,189   12,539,189  
July 2017 - Underwritten Public Offering [Member]                
Class of Stock [Line Items]                
Warrants, exercise price per share         $ 40.00      
Percentage Of Outstanding Common Stock         4.99%      
Outstanding common stock at election of purchaser         9.99%      
Warrant Exercises (in shares)         0 0    
Warrants outstanding         374,525      
Cantor Fitzgerald & Co. [Member]                
Class of Stock [Line Items]                
Aggregate offering price     $ 10,000,000.0          
Number of share sold under the sales agreement 3,281,067              
Total gross proceeds received $ 7,600,000              
Cantor Fitzgerald & Co. [Member] | August 2021 Controlled Equity Offering Sales Agreement [Member]                
Class of Stock [Line Items]                
Number of share sold under the sales agreement   3,117,100            
Total gross proceeds received   $ 4,494,496            
Aggregate purchase price   $ 4,494,496            
Reclassified shares   3,117,100            
Acorn Bioventures, LP [Member]                
Class of Stock [Line Items]                
Warrants to purchase shares         669,854      
Warrant outstanding Term         5 years      
Warrants, exercise price per share         $ 4.13      
Warrant Exercises (in shares)         0 0    
Co-Placement Agents [Member]                
Class of Stock [Line Items]                
Warrants, exercise price per share         $ 5.00      
Number of common shares called by each warrant         1      
Warrant Exercises (in shares)         0      
Warrants outstanding         2,190,000      
Co-Placement Agents [Member] | Common Stock Warrants                
Class of Stock [Line Items]                
Percentage Of Outstanding Common Stock         4.99%      
Outstanding common stock at election of purchaser         9.99%      
Notice period from the holder to increase the percentage of ownership of outstanding common stock after exercise of warrants         61 days      
Fractional shares issued         0      
Series B Convertible Preferred Stock                
Class of Stock [Line Items]                
Preferred stock, par value (in dollars per share)         $ 0.001   $ 0.001  
Preferred stock, shares issued         237,745   237,745  
Preferred stock, shares outstanding         237,745   237,745  
Outstanding common stock at election of purchaser         9.99%      
Number of shares converted         5      
Series A Convertible Preferred Stock                
Class of Stock [Line Items]                
Measurement period of consecutive trading days used in determining whether specified triggers are met which would allow the entity to require the conversion of all or part of outstanding preferred stock         30 days      
Preferred stock, par value (in dollars per share)         $ 0.001   $ 0.001  
Number of common shares issued upon conversion               215,200
Preferred stock, shares issued         264   264  
Preferred stock, shares outstanding         264   264  
Number of shares converted         6,600     8,608
Series A Convertible Preferred Stock | July 2017 - Underwritten Public Offering [Member]                
Class of Stock [Line Items]                
Effective Conversion price per share       $ 40.00        
Preferred stock, shares issued       8,872        
Price per share used to determine number of shares of common stock       $ 1,000        
Percentage of blocker provision       4.99%        
Conversion percentage       9.99%        
Series A Convertible Preferred Stock | Minimum                
Class of Stock [Line Items]                
Percentage by which the weighted average price of common stock during the measurement period exceeds the initial conversion price which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted         300.00%      
Threshold amount of daily trading volume on each trading day during the measurement period which triggers the right of the entity to cause all or part of the outstanding preferred stock to be converted         $ 500,000      
6% convertible exchangeable preferred stock                
Class of Stock [Line Items]                
Share issue price per share         $ 10.00      
Preferred stock, shares issued         335,273   335,273  
Preferred stock, shares outstanding         335,273   335,273  
Dividend rate on convertible exchangeable preferred stock (in percent)         6.00%   6.00%  
Accrued and unpaid dividends         $ 50,291      
Convertible Preferred Stock, Terms of Conversion         The Company may automatically convert the 6% Preferred Stock into common stock if the per share closing price of the Company’s common stock has exceeded $59,220, which is 150% of the conversion price of the 6% Preferred Stock, for at least 20 trading days during any 30 day trading period, ending within five trading days prior to notice of automatic conversion.      
Redemption price per share (in dollars per share)         $ 10.00      
Debt principal amount per share, basis for exchange (in dollars per share)         $ 10.00      
Debt Instrument, Term         25 years      
Liquidation preference (in dollars per share)         $ 10.00