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Note 2 - Summary of Significant Accounting Policies - Revenues and Accounts Receivable From Major Distribution Partners and Customers (Details) - Customer Concentration Risk [Member] | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Revenue from Contract with Customer Benchmark [Member] | Avenova via Amazon [Member] |  |  |
Distribution or collaboration partners | 59.00% | 50.00% | 15.00%
Revenue from Contract with Customer Benchmark [Member] | Distributor A [Member] |  |  |
Distribution or collaboration partners |  |  | 17.00%
Revenue from Contract with Customer Benchmark [Member] | Distributor B [Member] |  |  |
Distribution or collaboration partners |  |  | 16.00%
Revenue from Contract with Customer Benchmark [Member] | Distributor C [Member] |  |  |
Distribution or collaboration partners |  |  | 15.00%
Accounts Receivable [Member] | Major US Retailer [Member] |  |  |
Distribution or collaboration partners | 33.00% |  |
Accounts Receivable [Member] | Distributor A [Member] |  |  |
Distribution or collaboration partners | 13.00% | 18.00% |
Accounts Receivable [Member] | Distributor B [Member] |  |  |
Distribution or collaboration partners |  | 14.00% |
Accounts Receivable [Member] | Distributor C [Member] |  |  |
Distribution or collaboration partners | 11.00% | 14.00% |
Accounts Receivable [Member] | Chongqing Pioneer Pharma Holdings Limited [Member] |  |  |
Distribution or collaboration partners |  | 16.00% |
Accounts Receivable [Member] | Amazon [Member] |  |  |
Distribution or collaboration partners |  | 11.00% |

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- Definition For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 42 -URI http://asc.fasb.org/extlink&oid=123359005&loc=d3e9054-108599 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 275 -SubTopic 10 -Section 50 -Paragraph 18 -URI http://asc.fasb.org/extlink&oid=99393423&loc=d3e6351-108592 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 20 -URI http://asc.fasb.org/extlink&oid=123594938&loc=d3e13531-108611 Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 21 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123594938&loc=d3e13537-108611 Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 275 -SubTopic 10 -Section 50 -Paragraph 20 -URI http://asc.fasb.org/extlink&oid=99393423&loc=d3e6404-108592 + Details
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