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Note 2 - Summary of Significant Accounting Policies - Outstanding Stock Options and Stock Warrants Excluded From the Diluted Net Loss Per Share Computation (Details) - shares
shares in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Anti-dilutive securities (in shares) 48,998 10,220
Share-Based Payment Arrangement, Option [Member]    
Anti-dilutive securities (in shares) 4,416 3,138
Warrant [Member]    
Anti-dilutive securities (in shares) 44,582 7,082