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Note 14 - Stockholders' Equity (Details Textual)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Oct. 29, 2021
USD ($)
$ / shares
shares
Mar. 31, 2022
USD ($)
$ / shares
shares
Dec. 31, 2021
USD ($)
$ / shares
shares
Jun. 30, 2021
USD ($)
shares
Sep. 30, 2020
USD ($)
$ / shares
shares
Sep. 30, 2019
USD ($)
$ / shares
shares
Dec. 31, 2021
USD ($)
$ / shares
shares
Jan. 31, 2022
shares
Nov. 02, 2021
USD ($)
Jan. 15, 2021
$ / shares
shares
Dec. 31, 2020
USD ($)
Aug. 13, 2019
USD ($)
Preferred Stock, Shares Authorized (in shares) | shares   5,000,000 5,000,000       5,000,000          
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares   $ 0.71 $ 1.63       $ 1.63          
Common Stock, Shares Authorized (in shares) | shares   150,000,000 100,000,000       100,000,000 150,000,000        
Payments of Stock Issuance Costs         $ 200              
Preferred Stock, Shares Outstanding, Ending Balance (in shares) | shares   13,000 14,000       14,000          
Class of Warrant or Right, Issued During Period (in shares) | shares   37,500,000                    
Proceeds from Warrant Exercises         6,800              
Ladenburg Thalmann and Co. Inc. [Member]                        
Payments of Stock Issuance Costs           $ 300            
Private Placement, Commission Percentage           6.00%            
Payments of Stock Issuance Costs, Reimbursement of Expenses           $ 60            
Payments of Stock Issuance Costs, Other           $ 300            
China Kington [Member]                        
Payments of Stock Issuance Costs         $ 200              
The 2021 Warrants [Member]                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares 37,500,000                      
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares $ 0.53                      
Warrants and Rights Outstanding   $ 0 $ 9,600       $ 9,600   $ 14,200      
The 2019 Domestic Warrants [Member]                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares           4,198,566            
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares           $ 1.15            
Warrants and Rights Outstanding           $ 3,100         $ 4,900 $ 3,100
Payments of Stock Issuance Costs Allocated to Warrants           200            
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs           $ 300            
Class of Warrant or Right, Issued During Period (in shares) | shares           4,198,566            
The 2019 Ladenburg Warrants [Member]                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares           167,942            
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares         $ 0.99 $ 1.25            
Warrants and Rights Outstanding                     200 100
Payments of Stock Issuance Costs Allocated to Warrants           $ 59            
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs           $ 65            
Class of Warrant or Right, Issued During Period (in shares) | shares           167,942            
The 2019 Foreign Warrants [Member]                        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares         $ 0.99              
Warrants and Rights Outstanding                     $ 4,200 $ 2,000
Exercise of Warrants, Commission, Percent         6.00%              
New Warrants [Member]                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares         6,898,566              
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares         $ 1.65              
Warrants and Rights Outstanding, Term (Year)         5 years 6 months              
TLF Bio Innovation 2021 Warrants [Member]                        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares                   15,000    
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares                   $ 0.6718    
Warrants and Rights Outstanding, Term (Year)                   5 years    
Conversion of Series B Preferred Stock to Common Stock [Member]                        
Adjustments to Additional Paid in Capital, Beneficial Conversion Feature Upon Issuance of Stock     $ 700                  
The 2021 Private Placement Program [Member]                        
Payments of Stock Issuance Costs             1,700          
Payments of Stock Issuance Costs Allocated to Warrants             1,600          
The 2021 Private Placement Program [Member] | Conversion of Series B Preferred Stock to Common Stock [Member]                        
Preferred Stock, Convertible, Shares Issuable (in shares) | shares 37,500,000                      
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares $ 0.40                      
Preferred Stock, Convertible, Conversion Ratio 2,500                      
Maximum Percentage of Common Stock Outstanding 19.99%                      
Preferred Stock, Convertible, Maximum Common Stock Shares Converted (in shares) | shares 8,984,178                      
Conversion of Stock, Shares Converted (in shares) | shares   1,461                    
Conversion of Stock, Shares Issued (in shares) | shares   3,652,500                    
Convertible Preferred Stock, Shares Issued upon Conversion (in shares) | shares   2,500                    
ATM Program [Member]                        
Stock Issued During Period, Shares, New Issues (in shares) | shares       2,672,000                
Payments of Stock Issuance Costs       $ 100                
Proceeds from Issuance of Common Stock       $ 1,800                
August 2019 Common Stock Purchase Agreement [Member]                        
Stock Issued During Period, Shares, New Issues (in shares) | shares           4,198,566            
Payments of Stock Issuance Costs           $ 500            
Proceeds from Issuance of Stock and Warrants           $ 4,200            
Series B Preferred Stock [Member] | The 2021 Private Placement Program [Member]                        
Stock Issued During Period, Shares, New Issues (in shares) | shares 15,000                      
Preferred Stock, Convertible, Shares Issuable (in shares) | shares 37,500,000                      
Proceeds from Issuance of Preferred Stock and Preference Stock $ 14,900                      
Preferred Stock, Purchase Price (in dollars per share) | $ / shares $ 1,000                      
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs             $ 100