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Note 14 - Stockholders' Equity (Details Textual)
 3 Months Ended 6 Months Ended 12 Months Ended
Oct. 29, 2021
USD ($)
$ / shares
shares
Dec. 31, 2021
USD ($)
$ / shares
shares
Sep. 30, 2020
USD ($)
$ / shares
shares
Sep. 30, 2019
USD ($)
$ / shares
shares
Jun. 30, 2022
USD ($)
$ / shares
shares
Jun. 30, 2021
USD ($)
shares
Dec. 31, 2021
USD ($)
$ / shares
shares
Mar. 31, 2022
shares
Jan. 31, 2022
shares
Nov. 02, 2021
USD ($)
Jan. 15, 2021
$ / shares
shares
Dec. 31, 2020
USD ($)
Aug. 13, 2019
USD ($)
Common Stock, Shares Authorized (in shares) | shares   100,000,000     150,000,000   100,000,000   150,000,000        
Proceeds from Issuance of Common Stock           $ 1,775,000              
Payments of Stock Issuance Costs     $ 200,000                    
Preferred Stock, Shares Authorized (in shares) | shares   5,000,000     5,000,000   5,000,000            
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares   $ 1.63     $ 0.71   $ 1.63            
Preferred Stock, Shares Outstanding, Ending Balance (in shares) | shares   14,000     12,000   14,000            
Class of Warrant or Right, Issued During Period (in shares) | shares         37,500,000                
Proceeds from Warrant Exercises     6,800,000                    
Ladenburg Thalmann and Co. Inc. [Member]                          
Payments of Stock Issuance Costs       $ 300,000                  
Private Placement, Commission Percentage       6.00%                  
Payments of Stock Issuance Costs, Reimbursement of Expenses       $ 60,000                  
Payments of Stock Issuance Costs, Other       $ 300,000                  
China Kington [Member]                          
Payments of Stock Issuance Costs     $ 200,000                    
The 2021 Warrants [Member]                          
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares 37,500,000                        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares $ 0.53                        
Warrants and Rights Outstanding   $ 9,600,000     $ 0   $ 9,600,000     $ 14,200,000      
The 2019 Domestic Warrants [Member]                          
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares       $ 1.15                  
Warrants and Rights Outstanding       $ 3,100,000               $ 4,900,000 $ 3,100,000
Payments of Stock Issuance Costs Allocated to Warrants       200,000                  
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs       $ 300,000                  
The 2019 Foreign Warrants [Member]                          
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares     $ 0.99                    
Warrants and Rights Outstanding                       4,200,000 2,000,000.0
Exercise of Warrants, Commission, Percent     6.00%                    
The 2019 Ladenburg Warrants [Member]                          
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares       167,942                  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares     $ 0.99 $ 1.25                  
Warrants and Rights Outstanding                       $ 200,000 $ 100,000
Payments of Stock Issuance Costs Allocated to Warrants       $ 59,000                  
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs       $ 65,000                  
Class of Warrant or Right, Issued During Period (in shares) | shares       167,942                  
New Warrants [Member]                          
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares     6,898,566                    
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares     $ 1.65                    
Warrants and Rights Outstanding, Term (Year)     5 years 6 months                    
TLF Bio Innovation 2021 Warrants [Member]                          
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares                     15,000    
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares                     $ 0.6718    
Warrants and Rights Outstanding, Term (Year)                     5 years    
Conversion of Series B Preferred Stock to Common Stock [Member]                          
Adjustments to Additional Paid in Capital, Beneficial Conversion Feature Upon Issuance of Stock   $ 700,000                      
ATM Program [Member]                          
Stock Issued During Period, Shares, New Issues (in shares) | shares           2,672,000              
Proceeds from Issuance of Common Stock           $ 1.8              
Payments of Stock Issuance Costs           $ 0.1              
The 2021 Private Placement Program [Member]                          
Payments of Stock Issuance Costs             1,700,000            
Payments of Stock Issuance Costs Allocated to Warrants             1,600,000            
The 2021 Private Placement Program [Member] | Conversion of Series B Preferred Stock to Common Stock [Member]                          
Preferred Stock, Convertible, Shares Issuable (in shares) | shares 37,500,000                        
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares $ 0.40                        
Preferred Stock, Convertible, Conversion Ratio 2,500                        
Maximum Percentage of Common Stock Outstanding 19.99%                        
Preferred Stock, Convertible, Maximum Common Stock Shares Converted (in shares) | shares 8,984,178                        
Conversion of Stock, Shares Converted (in shares) | shares         3,380                
Conversion of Stock, Shares Issued (in shares) | shares         8,450,000                
Convertible Preferred Stock, Shares Issued upon Conversion (in shares) | shares               2,500          
The 2021 Private Placement Program [Member] | Series B Preferred Stock [Member]                          
Stock Issued During Period, Shares, New Issues (in shares) | shares 15,000                        
Proceeds from Issuance of Preferred Stock and Preference Stock $ 14,900,000                        
Preferred Stock, Purchase Price (in dollars per share) | $ / shares $ 1,000                        
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs             $ 100,000            
August 2019 Common Stock Purchase Agreement [Member]                          
Stock Issued During Period, Shares, New Issues (in shares) | shares       4,198,566                  
Payments of Stock Issuance Costs       $ 500,000                  
Proceeds from Issuance or Sale of Equity, Total       $ 4,200,000                  
August 2019 Common Stock Purchase Agreement [Member] | The 2019 Domestic Warrants [Member]                          
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares       4,198,566                  
Class of Warrant or Right, Issued During Period (in shares) | shares       4,198,566                  
August 2019 Common Stock Purchase Agreement 2 [Member]                          
Proceeds from Issuance or Sale of Equity, Total       $ 2,700,000                  
August 2019 Common Stock Purchase Agreement 2 [Member] | The 2019 Foreign Warrants [Member]                          
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares       2,700,000                  
Class of Warrant or Right, Issued During Period (in shares) | shares       2,700,000                  
August 2019 Common Stock Purchase Agreement 2 [Member] | Series A Preferred Stock [Member]                          
Stock Issued During Period, Shares, New Issues (in shares) | shares       2,700,000