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Note 2 - Summary of Significant Accounting Policies - Outstanding Stock Options and Stock Warrants Excluded From the Diluted Net Loss Per Share Computation (Details) - shares
9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Anti-dilutive securities (in shares) 71,586,000 11,029,000
Series B Preferred [Member]    
Anti-dilutive securities (in shares) 64,561 0
Share-Based Payment Arrangement, Option [Member]    
Anti-dilutive securities (in shares) 4,743,000 3,947,000
Warrant [Member]    
Anti-dilutive securities (in shares) 2,282,000 7,082,000