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Note 14 - Stockholders' Equity (Details Textual)
$ / shares in Units, $ in Thousands
 3 Months Ended 4 Months Ended 9 Months Ended 12 Months Ended
Sep. 09, 2022
USD ($)
$ / shares
shares
Oct. 29, 2021
USD ($)
$ / shares
shares
Sep. 30, 2022
USD ($)
$ / shares
shares
Dec. 31, 2021
USD ($)
$ / shares
shares
Sep. 30, 2021
USD ($)
Jun. 30, 2021
USD ($)
shares
Sep. 30, 2020
USD ($)
$ / shares
shares
Sep. 30, 2019
USD ($)
$ / shares
shares
Dec. 31, 2022
USD ($)
Sep. 30, 2022
USD ($)
$ / shares
shares
Sep. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
$ / shares
shares
Sep. 08, 2022
USD ($)
$ / shares
Nov. 30, 2021
$ / shares
Nov. 02, 2021
USD ($)
Jan. 15, 2021
$ / shares
shares
Dec. 31, 2020
USD ($)
Aug. 13, 2019
USD ($)
Common Stock, Shares Authorized (in shares) | shares     150,000,000 100,000,000           150,000,000   100,000,000            
Preferred Stock, Shares Authorized (in shares) | shares     5,000,000 5,000,000           5,000,000   5,000,000            
Gain (Loss) on Modification of Warrants     $ (1,922)   $ 0         $ (1,922) $ 0              
Class of Warrant or Right, Exercised During Period (in shares) | shares                   11,475,000                
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares     $ 1.59 $ 1.63           $ 1.59   $ 1.63            
Proceeds from Warrant Exercises             $ 6,800     $ 1,703 0              
Payments of Stock Issuance Costs             200                      
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares     $ 0.01 $ 0.01           $ 0.01   $ 0.01            
Preferred Stock, Change in Conversion Price, Income Statement Impact     $ 5,657   $ 0         $ 5,657 0              
Preferred Stock, Shares Outstanding, Ending Balance (in shares) | shares     12,000 14,000           12,000   14,000            
Class of Warrant or Right, Outstanding (in shares) | shares     2,282,000 7,082,000           2,282,000   7,082,000            
Class of Warrant or Right, Issued During Period (in shares) | shares                   37,500,000                
Proceeds from Issuance of Common Stock                     $ 1,994              
Conversion of Series B Preferred Stock to Common Stock [Member]                                    
Adjustments to Additional Paid in Capital, Beneficial Conversion Feature Upon Issuance of Stock       $ 700                            
The 2021 Private Placement Program [Member]                                    
Payments of Stock Issuance Costs                       $ 1,700            
Payments of Stock Issuance Costs Allocated to Warrants                       1,600            
The 2021 Private Placement Program [Member] | Conversion of Series B Preferred Stock to Common Stock [Member]                                    
Preferred Stock, Convertible, Shares Issuable (in shares) | shares   37,500,000                                
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares   $ 0.40 $ 0.40             $ 0.40                
Preferred Stock, Convertible, Conversion Ratio   2,500 2,500             2,500                
Conversion of Stock, Shares Converted (in shares) | shares                   3,380                
Conversion of Stock, Shares Issued (in shares) | shares                   8,450,000                
August 2019 Common Stock Purchase Agreement [Member]                                    
Payments of Stock Issuance Costs               $ 500                    
Proceeds from Issuance or Sale of Equity, Total               $ 4,200                    
Stock Issued During Period, Shares, New Issues (in shares) | shares               4,198,566                    
August 2019 Common Stock Purchase Agreement 2 [Member]                                    
Proceeds from Issuance or Sale of Equity, Total               $ 2,700                    
ATM Program [Member]                                    
Payments of Stock Issuance Costs           $ 100                        
Stock Issued During Period, Shares, New Issues (in shares) | shares           2,672,000                        
Proceeds from Issuance of Common Stock           $ 1,800                        
Series C Preferred Stock [Member]                                    
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares $ 0.01                                  
Series C Preferred Stock [Member] | Forecast [Member]                                    
Proceeds from Issuance or Sale of Equity, Total                 $ 3,300                  
Series B Preferred Stock [Member]                                    
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares $ 0.18                       $ 0.40          
Convertible Preferred Stock, Shares Issued upon Conversion (in shares) | shares 5,556                                  
Preferred Stock, Change in Conversion Price, Income Statement Impact $ 5,700                                  
Preferred Stock, Fair Value Disclosure 12,500                       $ 6,900          
Series B Preferred Stock [Member] | The 2021 Private Placement Program [Member]                                    
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs                       100            
Stock Issued During Period, Shares, New Issues (in shares) | shares   15,000                                
Proceeds from Issuance of Preferred Stock and Preference Stock   $ 14,900                                
Preferred Stock, Purchase Price (in dollars per share) | $ / shares   $ 1,000                                
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares     $ 0.18             $ 0.18                
Convertible Preferred Stock, Shares Issued upon Conversion (in shares) | shares     5,556             5,556                
Preferred Stock, Shares Outstanding, Ending Balance (in shares) | shares     11,620             11,620                
Series A Preferred Stock [Member] | August 2019 Common Stock Purchase Agreement 2 [Member]                                    
Stock Issued During Period, Shares, New Issues (in shares) | shares               2,700,000                    
Ladenburg Thalmann and Co. Inc. [Member]                                    
Payments of Stock Issuance Costs               $ 300                    
Private Placement, Commission Percentage               6.00%                    
Payments of Stock Issuance Costs, Reimbursement of Expenses               $ 60                    
Payments of Stock Issuance Costs, Other               300                    
China Kington [Member]                                    
Payments of Stock Issuance Costs             $ 200                      
The July 2020 and November 2021 Warrants [Member]                                    
Gain (Loss) on Modification of Warrants (1,900)                                  
Warrants and Rights Outstanding 5,200                       $ 3,300          
The November 2021 Warrants [Member]                                    
Warrants and Rights Outstanding $ 3,500   $ 1,900             $ 1,900                
Class of Warrant or Right, Exercised During Period (in shares) | shares 9,375,000                                  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares $ 0.18                         $ 0.53        
Proceeds from Warrant Exercises $ 700                                  
Class of Warrant or Right, Outstanding (in shares) | shares     28,125,000             28,125,000                
Class of Warrant or Right, Excluded from Outstanding Balance (in shares) | shares     28,125,000             28,125,000                
Amended July 2020 Warrants [Member]                                    
Warrants and Rights Outstanding $ 300   $ 100             $ 100                
Class of Warrant or Right, Exercised During Period (in shares) | shares 2,100,000                                  
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares 4,800,000   4,800,000             4,800,000                
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares $ 0.18   $ 0.18             $ 0.18                
Proceeds from Warrant Exercises $ 1,400                                  
Class of Warrant or Right, Outstanding (in shares) | shares 2,700,000                                  
Class of Warrant or Right, Excluded from Outstanding Balance (in shares) | shares     2,700,000             2,700,000                
The 2022 Warrant Reprice Transaction [Member]                                    
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares 11,475,000                                  
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares $ 0.18                                  
Proceeds from Warrant Exercises $ 2,100                                  
Payments of Stock Issuance Costs 529                                  
Payments of Stock Issuance Costs Allocated to Warrants 166                                  
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs $ 363                                  
The 2022 Warrant Reprice Transaction [Member] | Ladenburg Thalmann and Co. Inc. [Member]                                    
Exercise of Warrants, Commission, Percent 8.00%                                  
The 2021 Warrants [Member]                                    
Warrants and Rights Outstanding       $ 9,600               $ 9,600     $ 14,200      
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares   37,500,000                                
September 2022 Warrants [Member]                                    
Warrants and Rights Outstanding $ 1,400   $ 800             $ 800                
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares $ 0.18                                  
Class of Warrant or Right, Excluded from Outstanding Balance (in shares) | shares     11,475,000             11,475,000                
The 2019 Domestic Warrants [Member]                                    
Warrants and Rights Outstanding               $ 3,100                 $ 4,900 $ 3,100
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares               $ 1.15                    
Payments of Stock Issuance Costs Allocated to Warrants               $ 200                    
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs               $ 300                    
Class of Warrant or Right, Outstanding (in shares) | shares     0             0                
The 2019 Domestic Warrants [Member] | August 2019 Common Stock Purchase Agreement [Member]                                    
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares               4,198,566                    
Class of Warrant or Right, Issued During Period (in shares) | shares               4,198,566                    
The 2019 Foreign Warrants [Member]                                    
Warrants and Rights Outstanding                                 4,200 2,000
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares             $ 0.99                      
Exercise of Warrants, Commission, Percent             6.00%                      
The 2019 Foreign Warrants [Member] | August 2019 Common Stock Purchase Agreement 2 [Member]                                    
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares               2,700,000                    
Class of Warrant or Right, Issued During Period (in shares) | shares               2,700,000                    
The 2019 Ladenburg Warrants [Member]                                    
Warrants and Rights Outstanding                                 $ 200 $ 100
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares               167,942                    
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares             $ 0.99 $ 1.25                    
Payments of Stock Issuance Costs Allocated to Warrants               $ 59                    
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs               $ 65                    
Class of Warrant or Right, Issued During Period (in shares) | shares               167,942                    
New Warrants [Member]                                    
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares             6,898,566                      
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares             $ 1.65                      
Warrants and Rights Outstanding, Term (Year)             5 years 6 months                      
Unamended July 2020 Warrants [Member]                                    
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares     2,098,566             2,098,566                
TLF Bio Innovation 2021 Warrants [Member]                                    
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares                               15,000    
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares                               $ 0.6718    
Warrants and Rights Outstanding, Term (Year)                               5 years