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Note 14 - Stockholders' Equity (Details Textual) |  |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |  |  |  |  |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Dec. 31, 2022 USD ($) $ / shares shares | Nov. 15, 2022 $ / shares | Sep. 09, 2022 USD ($) $ / shares shares | Oct. 29, 2021 USD ($) $ / shares shares | Mar. 31, 2021 shares | Dec. 31, 2021 USD ($) $ / shares shares | Jun. 30, 2021 USD ($) shares | Dec. 31, 2020 USD ($) $ / shares shares | Sep. 30, 2020 USD ($) $ / shares | Jun. 30, 2020 USD ($) shares | Mar. 31, 2020 USD ($) shares | Sep. 30, 2019 USD ($) $ / shares shares | Jun. 30, 2019 USD ($) $ / shares shares | Dec. 31, 2015 shares | Mar. 31, 2015 $ / shares shares | Sep. 30, 2011 $ / shares shares | Dec. 31, 2022 USD ($) $ / shares shares | Dec. 31, 2021 USD ($) $ / shares shares | Dec. 31, 2019 USD ($) shares | Nov. 10, 2022 USD ($) | Sep. 08, 2022 USD ($) $ / shares | Jan. 31, 2022 shares | Nov. 02, 2021 USD ($) | Oct. 27, 2021 $ / shares | Jan. 15, 2021 $ / shares shares | Jul. 31, 2020 $ / shares shares | Aug. 13, 2019 USD ($) | May 31, 2019 $ / shares | Feb. 29, 2016 $ / shares | Oct. 31, 2015 $ / shares
Common Stock, Shares Authorized (in shares) | 150,000,000 |  |  |  |  | 100,000,000 |  |  |  |  |  |  |  |  |  |  | 150,000,000 | 100,000,000 |  |  |  | 150,000,000 |  |  |  |  |  |  |  |
Preferred Stock, Shares Authorized (in shares) | 5,000,000 |  |  |  |  | 5,000,000 |  |  |  |  |  |  |  |  |  |  | 5,000,000 | 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 7.70 |  |  |  |  | $ 57.13 |  | $ 57.13 |  |  |  |  |  |  |  |  | $ 7.70 | $ 57.13 |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises | $ |  |  |  |  |  |  |  |  | $ 6,800,000 |  |  |  |  |  |  |  | $ 1,703,000 | $ 0 |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  |  |  |  |  |  |  |  | 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Adjustments to Additional Paid in Capital, Beneficial Conversion Feature Upon Issuance of Stock | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 735,000 |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) | 2,306,000 |  |  |  |  | 202,000 |  | 201,000 |  |  |  |  |  |  |  |  | 2,306,000 | 202,000 |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0 | $ 1,776,000 |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,431,000 | 1,000 |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercised During Period (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 327,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Gain (Loss) on Modification of Warrants | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (1,922,000) | $ 0 |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Series B Preferred Stock to Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Adjustments to Additional Paid in Capital, Beneficial Conversion Feature Upon Issuance of Stock | $ |  |  |  |  |  | $ 700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The 2022 Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity, Total | $ |  |  | $ 3,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The 2022 Private Placement [Member] | Conversion of Series C Preferred Stock to Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Shares Issuable (in shares) |  |  | 516,750 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The 2021 Private Placement Program [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs Allocated to Warrants | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |
The 2021 Private Placement Program [Member] | Conversion of Series B Preferred Stock to Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Shares Issuable (in shares) |  |  |  | 37,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum Percentage of Common Stock Outstanding |  |  |  | 19.99% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,380 |  |  |  |  |  |  |  |  |  |  |  |  |
The 2021 Private Placement Program [Member] | Conversion of Series B Preferred Stock to Common Stock [Member] | Stock Restatement From Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Shares Issuable (in shares) |  |  |  | 1,071,429 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
ATM Program [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  |  |  |  | 2,672,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock | $ |  |  |  |  |  |  | $ 1,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
August 2019 Common Stock Purchase Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  |  |  |  |  |  |  |  |  |  |  | $ 500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  |  |  |  |  |  |  |  |  | 4,198,566 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity, Total | $ |  |  |  |  |  |  |  |  |  |  |  | $ 4,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  |  |  |  |  |  |  |  |  |  |  |  | $ 27,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Series C Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) | 2,000 |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  | 2,000 | 0 |  |  |  |  |  |  |  |  |  |  |  |
Series C Preferred Stock [Member] | The 2022 Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  | 3,250 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Series B Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares |  | $ 6.30 | $ 0.18 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.40 |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Ratio |  | 159 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Preferred Stock, Shares Issued upon Conversion (in shares) |  |  | 5,556 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Change in Conversion Price, Income Statement Impact | $ |  |  | $ 5,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Fair Value Disclosure | $ |  |  | 12.5 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 6,900,000 |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) | 12,000 |  |  |  |  | 14,000 |  |  |  |  |  |  |  |  |  |  | 12,000 | 14,000 |  |  |  |  |  |  |  |  |  |  |  |
Series B Preferred Stock [Member] | The 2021 Private Placement Program [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  | 15,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Preferred Stock and Preference Stock | $ |  |  |  | $ 14,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Purchase Price (in dollars per share) | $ / shares |  |  |  | $ 1,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares | $ 6.30 |  |  | $ 0.40 |  |  |  |  |  |  |  |  |  |  |  |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Ratio | 159 |  |  | 2,500 |  |  |  |  |  |  |  |  |  |  |  |  | 159 |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) | 11,620 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 11,620 |  |  |  |  |  |  |  |  |  |  |  |  |
Ladenburg Thalmann and Co. Inc. [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Private Placement, Commission Percentage |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6.00% |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs, Reimbursement of Expenses | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 60,000 |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs, Other | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 300,000 |  |  |  |  |  |  |  |  |  |  |
China Kington [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  |  |  |  |  |  |  |  | $ 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
China Kington [Member] | Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Private Placement, Commission Percentage |  |  |  |  |  |  |  |  |  |  |  |  | 6.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Three Accredited Investors [Member] | Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  |  |  |  |  |  |  |  |  |  |  | 1,371,427 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of Stock and Warrants During the Period, Value | $ |  |  |  |  |  |  |  |  |  |  |  |  | $ 2,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Xiao Rui Liu [Member] | Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of Stock and Warrants During the Period, Value | $ |  |  |  |  |  |  |  |  |  |  |  |  | 1,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Hai Dong Pang [Member] | Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of Stock and Warrants During the Period, Value | $ |  |  |  |  |  |  |  |  |  |  |  |  | 400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ping Huang [Member] | Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of Stock and Warrants During the Period, Value | $ |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The July 2020 and November 2021 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  |  | 5,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 3,300,000 |  |  |  |  |  |  |  |  |
Gain (Loss) on Modification of Warrants | $ |  |  | $ (1,900,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The 2022 Warrant Reprice Transaction [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  | 327,860 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises | $ |  |  | $ 2,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  |  | 529,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs Allocated to Warrants | $ |  |  | 166,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | $ |  |  | $ 363,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The 2022 Warrant Reprice Transaction [Member] | Ladenburg Thalmann and Co. Inc. [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of Warrants, Commission, Percent |  |  | 8.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The November 2021 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  |  |  |  |  | $ 9,600,000 |  |  |  |  |  |  |  |  |  |  |  | $ 9,600,000 |  | $ 1,300,000 |  |  | $ 14,200,000 |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  | $ 0.18 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises | $ |  |  | $ 700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) | 803,574 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 803,574 |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercised During Period (in shares) |  |  | 9,375,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The November 2021 Warrants [Member] | Stock Restatement From Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amended July 2020 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ | $ 100,000 |  | $ 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  | 4,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  | $ 0.18 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises | $ |  |  | $ 1,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) |  |  | 2,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercised During Period (in shares) |  |  | 2,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The 2022 Private Placement Short Term Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 515,876 |  | 515,876 |  |  |  |  |  |  |  |  |  |  |  |  |  | 515,876 |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The 2022 Private Placement Long Term Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 515,876 |  | 515,876 |  |  |  |  |  |  |  |  |  |  |  |  |  | 515,876 |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The 2022 Private Placement Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 1,031,752 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,031,752 |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Date from which Warrants or Rights Exercisable | Mar. 09, 2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The 2021 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 14,200,000 |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  | 37,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The 2021 Warrants [Member] | Stock Restatement From Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  | 1,071,429 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
September 2022 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  |  | $ 1,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 500,000 |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  | $ 0.18 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
TLF Bio Innovation 2021 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 15,000 |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.6718 |  |  |  |  |
Warrants and Rights Outstanding, Term (Year) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |
TLF Bio Innovation 2021 Warrants [Member] | Stock Restatement From Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 429 |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 23.5130 |  |  |  |  |
The 2019 Domestic Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  |  |  |  |  |  |  | $ 4,900,000 |  |  |  | $ 3,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 3,100,000 |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  | $ 1.15 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs Allocated to Warrants | $ |  |  |  |  |  |  |  |  |  |  |  | $ 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | $ |  |  |  |  |  |  |  |  |  |  |  | $ 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |
The 2019 Domestic Warrants [Member] | August 2019 Common Stock Purchase Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  |  |  |  |  |  |  | 4,198,566 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  |  |  |  |  |  |  |  |  | 4,198,566 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The 2019 Foreign Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  |  |  |  |  |  |  | 4,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,000,000.0 |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 0.99 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of Warrants, Commission, Percent |  |  |  |  |  |  |  |  | 6.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |
New Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,898,566 |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.65 |  |  |  |
Warrants and Rights Outstanding, Term (Year) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years 6 months |  |  |  |
The 2019 Ladenburg Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  |  |  |  |  |  |  | $ 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000 |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 0.99 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 300,000 |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs Allocated to Warrants | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 59,000 |  |  |  |  |  |  |  |  |  |  |
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 65,000 |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 167,942 |  |  |  |  |  |  |  |  |  |  |
The 2019 Ladenburg Warrants [Member] | Stock Restatement From Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 34.65 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,799 |  |  |  |  |  |  |  |  |  |  |
The June 2019 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  |  |  |  |  |  |  |  | 1,371,427 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.87 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises | $ |  |  |  |  |  |  |  |  |  | $ 497 | $ 199 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  |  |  |  |  |  |  |  |  |  | 1,371,427 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right Call Feature Minimum Stock Price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercised During Period (in shares) |  |  |  |  |  |  |  |  |  | 571,428 | 228,571 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Expired During Period (in shares) |  |  |  |  |  |  | 571,428 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The June 2019 Warrants [Member] | China Kington [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of Warrants, Commission, Percent |  |  |  |  |  |  |  |  |  | 6.00% | 6.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments for Commission, Exercise of Warrants | $ |  |  |  |  |  |  |  |  |  | $ 29 | $ 12 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
October 2015 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  | 442,802 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5.00 |  |  |  | $ 0.2061 | $ 1.81 |
Proceeds from Warrant Exercises | $ |  |  |  |  |  | $ 5,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  | 442,802 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercised During Period (in shares) |  |  |  |  |  | 22,680 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Expired During Period (in shares) |  |  |  |  |  |  |  | 15,320 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
March 2015 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |
March 2015 Warrants [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 15.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
March 2015 Warrants [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 16.25 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
March 2015 Short-term and Long-term Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 649,133 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.2061 | 1.81 | $ 5.00
Proceeds from Warrant Exercises | $ |  |  |  |  |  |  |  |  |  |  | $ 14,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 649,133 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercised During Period (in shares) |  |  |  |  |  |  |  |  |  |  | 70,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Expired During Period (in shares) |  |  |  |  |  |  |  |  |  |  | 7,419 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
March 2015 Warrants Expiring March 6, 2020 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 278,200 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
March 2015 Warrants Expiring June 6, 2015 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 370,933 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The July 2011 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 139,520 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 33.25 |  |  |  |  |  |  |  |  |  |  |  | $ 0.2061 | $ 1.81 | $ 5.00
Class of Warrant or Right, Outstanding (in shares) | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 139,520 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Expired During Period (in shares) |  |  |  |  | 35,107 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
The July 2020 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio |  | 35 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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