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Note 13 - Warrant Liability (Tables)
 12 Months Ended
Dec. 31, 2022
Notes Tables  
Schedule of Derivative Instruments [Table Text Block]

Expected price volatility

  79.6

%

Expected term (in years)

  6.0 

Risk-free interest rate

  3.43

%

Dividend yield

  0.0

%

Weighted-average fair value of warrants

 $4.55 

Expected price volatility

  79.5

%

Expected term (in years)

  5.8 

Risk-free interest rate

  3.93

%

Dividend yield

  0.0

%

Weighted-average fair value of warrants

 $1.40 

Expected price volatility

  84.9

%

Expected term (in years)

  6.2 

Risk-free interest rate

  1.29

%

Dividend yield

  0.00

%

Weighted-average fair value of warrants

 $13.30 

Expected price volatility

  87

%

Expected term (in years)

  6.0 

Risk-free interest rate

  1.31

%

Dividend yield

  0.00

%

Weighted-average fair value of warrants

 $8.75 

Expected price volatility

  79.6

%

Expected term (in years)

  6.0 

Risk-free interest rate

  3.43

%

Dividend yield

  0.00

%

Weighted-average fair value of warrants

 $4.55 

Expected price volatility

  79.5

%

Expected term (in years)

  5.8 

Risk-free interest rate

  3.93

%

Dividend yield

  0.00

%

Weighted-average fair value of warrants

 $1.40 

Expected price volatility

  79.6

%

Expected term (in years)

  3.4 

Risk-free interest rate

  3.58

%

Dividend yield

  0.00

%

Weighted-average fair value of warrants

 $3.50 

Expected price volatility

  79.5

%

Expected term (in years)

  3.2 

Risk-free interest rate

  4.15

%

Dividend yield

  0.00

%

Weighted-average fair value of warrants

 $1.05 

Assumptions

 

2019 Domestic

Warrants

  

2019 Foreign

Warrants

 

Expected price volatility

  178

%

  178

%

Expected term (in years)

  4.57   4.57 

Risk-free interest rate

  0.25

%

  0.27

%

Dividend yield

  0.00

%

  0.00

%

Weighted-average fair value of warrant

 $41.30  $53.90 

Expected price volatility

  186

%

Expected term (in years)

  4.05 

Risk-free interest rate

  0.22

%

Dividend yield

  0.00

%

Weighted-average fair value of warrants

 $40.95