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Note 14 - Stockholders' Equity (Details Textual)					1 Months Ended	3 Months Ended											12 Months Ended
	Dec. 31, 2022 USD ($) $ / shares shares	Nov. 15, 2022 $ / shares	Sep. 09, 2022 USD ($) $ / shares shares	Oct. 29, 2021 USD ($) $ / shares shares	Mar. 31, 2021 shares	Dec. 31, 2021 USD ($) $ / shares shares	Jun. 30, 2021 USD ($) shares	Dec. 31, 2020 USD ($) $ / shares shares	Sep. 30, 2020 USD ($) $ / shares	Jun. 30, 2020 USD ($) shares	Mar. 31, 2020 USD ($) shares	Sep. 30, 2019 USD ($) $ / shares shares	Jun. 30, 2019 USD ($) $ / shares shares	Dec. 31, 2015 shares	Mar. 31, 2015 $ / shares shares	Sep. 30, 2011 $ / shares shares	Dec. 31, 2022 USD ($) $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2019 USD ($) shares	Nov. 10, 2022 USD ($)	Sep. 08, 2022 USD ($) $ / shares	Jan. 31, 2022 shares	Nov. 02, 2021 USD ($)	Oct. 27, 2021 $ / shares	Jan. 15, 2021 $ / shares shares	Jul. 31, 2020 $ / shares shares	Aug. 13, 2019 USD ($)	May 31, 2019 $ / shares	Feb. 29, 2016 $ / shares	Oct. 31, 2015 $ / shares
Common Stock, Shares Authorized (in shares)	150,000,000					100,000,000											150,000,000	100,000,000				150,000,000
Preferred Stock, Shares Authorized (in shares)	5,000,000					5,000,000											5,000,000	5,000,000
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares	$ 7.70					$ 57.13		$ 57.13									$ 7.70	$ 57.13
Proceeds from Warrant Exercises | $									$ 6,800,000								$ 1,703,000	$ 0
Payments of Stock Issuance Costs | $									200,000
Adjustments to Additional Paid in Capital, Beneficial Conversion Feature Upon Issuance of Stock | $																		$ 735,000
Class of Warrant or Right, Outstanding (in shares)	2,306,000					202,000		201,000									2,306,000	202,000
Proceeds from Issuance of Common Stock | $																	$ 0	$ 1,776,000
Class of Warrant or Right, Issued During Period (in shares)																	2,431,000	1,000
Class of Warrant or Right, Exercised During Period (in shares)																	327,000
Gain (Loss) on Modification of Warrants | $																	$ (1,922,000)	$ 0
Conversion of Series B Preferred Stock to Common Stock [Member]
Adjustments to Additional Paid in Capital, Beneficial Conversion Feature Upon Issuance of Stock | $						$ 700,000
The 2022 Private Placement [Member]
Proceeds from Issuance or Sale of Equity, Total | $			$ 3,200,000
The 2022 Private Placement [Member] | Conversion of Series C Preferred Stock to Common Stock [Member]
Preferred Stock, Convertible, Shares Issuable (in shares)			516,750
The 2021 Private Placement Program [Member]
Payments of Stock Issuance Costs | $																	1,700,000
Payments of Stock Issuance Costs Allocated to Warrants | $																	$ 1,600,000
The 2021 Private Placement Program [Member] | Conversion of Series B Preferred Stock to Common Stock [Member]
Preferred Stock, Convertible, Shares Issuable (in shares)				37,500,000
Maximum Percentage of Common Stock Outstanding				19.99%
Conversion of Stock, Shares Converted (in shares)																	3,380
The 2021 Private Placement Program [Member] | Conversion of Series B Preferred Stock to Common Stock [Member] | Stock Restatement From Reverse Stock Split [Member]
Preferred Stock, Convertible, Shares Issuable (in shares)				1,071,429
ATM Program [Member]
Payments of Stock Issuance Costs | $							$ 100,000
Stock Issued During Period, Shares, New Issues (in shares)							2,672,000
Proceeds from Issuance of Common Stock | $							$ 1,800,000
August 2019 Common Stock Purchase Agreement [Member]
Payments of Stock Issuance Costs | $												$ 500,000
Stock Issued During Period, Shares, New Issues (in shares)												4,198,566
Proceeds from Issuance or Sale of Equity, Total | $												$ 4,200,000
Private Placement [Member]
Payments of Stock Issuance Costs | $													$ 27,000
Series C Preferred Stock [Member]
Preferred Stock, Shares Outstanding, Ending Balance (in shares)	2,000					0											2,000	0
Series C Preferred Stock [Member] | The 2022 Private Placement [Member]
Stock Issued During Period, Shares, New Issues (in shares)			3,250
Series B Preferred Stock [Member]
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares		$ 6.30	$ 0.18																		$ 0.40
Preferred Stock, Convertible, Conversion Ratio		159
Convertible Preferred Stock, Shares Issued upon Conversion (in shares)			5,556
Preferred Stock, Change in Conversion Price, Income Statement Impact | $			$ 5,700,000
Preferred Stock, Fair Value Disclosure | $			12.5																		$ 6,900,000
Preferred Stock, Shares Outstanding, Ending Balance (in shares)	12,000					14,000											12,000	14,000
Series B Preferred Stock [Member] | The 2021 Private Placement Program [Member]
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | $																	$ 100,000
Stock Issued During Period, Shares, New Issues (in shares)				15,000
Proceeds from Issuance of Preferred Stock and Preference Stock | $				$ 14,900,000
Preferred Stock, Purchase Price (in dollars per share) | $ / shares				$ 1,000
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares	$ 6.30			$ 0.40													$ 6.30
Preferred Stock, Convertible, Conversion Ratio	159			2,500													159
Preferred Stock, Shares Outstanding, Ending Balance (in shares)	11,620																11,620
Ladenburg Thalmann and Co. Inc. [Member]
Private Placement, Commission Percentage																			6.00%
Payments of Stock Issuance Costs, Reimbursement of Expenses | $																			$ 60,000
Payments of Stock Issuance Costs, Other | $																			300,000
China Kington [Member]
Payments of Stock Issuance Costs | $									$ 200,000
China Kington [Member] | Private Placement [Member]
Payments of Stock Issuance Costs | $													$ 100,000
Private Placement, Commission Percentage													6.00%
Three Accredited Investors [Member] | Private Placement [Member]
Stock Issued During Period, Shares, New Issues (in shares)													1,371,427
Issuance of Stock and Warrants During the Period, Value | $													$ 2,400,000
Xiao Rui Liu [Member] | Private Placement [Member]
Issuance of Stock and Warrants During the Period, Value | $													1,000,000.0
Hai Dong Pang [Member] | Private Placement [Member]
Issuance of Stock and Warrants During the Period, Value | $													400,000
Ping Huang [Member] | Private Placement [Member]
Issuance of Stock and Warrants During the Period, Value | $													$ 1,000,000.0
The July 2020 and November 2021 Warrants [Member]
Warrants and Rights Outstanding | $			5,200,000																		$ 3,300,000
Gain (Loss) on Modification of Warrants | $			$ (1,900,000)
The 2022 Warrant Reprice Transaction [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)			327,860
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares			$ 6.30
Proceeds from Warrant Exercises | $			$ 2,100,000
Payments of Stock Issuance Costs | $			529,000
Payments of Stock Issuance Costs Allocated to Warrants | $			166,000
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | $			$ 363,000
The 2022 Warrant Reprice Transaction [Member] | Ladenburg Thalmann and Co. Inc. [Member]
Exercise of Warrants, Commission, Percent			8.00%
The November 2021 Warrants [Member]
Warrants and Rights Outstanding | $						$ 9,600,000												$ 9,600,000		$ 1,300,000			$ 14,200,000
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares			$ 0.18
Proceeds from Warrant Exercises | $			$ 700,000
Class of Warrant or Right, Outstanding (in shares)	803,574																803,574
Class of Warrant or Right, Exercised During Period (in shares)			9,375,000
The November 2021 Warrants [Member] | Stock Restatement From Reverse Stock Split [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares			$ 6.30
Amended July 2020 Warrants [Member]
Warrants and Rights Outstanding | $	$ 100,000		$ 300,000														$ 100,000
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)			4,800,000
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares			$ 0.18
Proceeds from Warrant Exercises | $			$ 1,400,000
Class of Warrant or Right, Outstanding (in shares)			2,700,000
Class of Warrant or Right, Exercised During Period (in shares)			2,100,000
The 2022 Private Placement Short Term Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)	515,876		515,876														515,876
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares			$ 6.30
The 2022 Private Placement Long Term Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)	515,876		515,876														515,876
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares			$ 6.30
The 2022 Private Placement Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)	1,031,752																1,031,752
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares	$ 6.30																$ 6.30
Class of Warrant or Right, Date from which Warrants or Rights Exercisable	Mar. 09, 2023
The 2021 Warrants [Member]
Warrants and Rights Outstanding | $																							$ 14,200,000
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)				37,500,000
The 2021 Warrants [Member] | Stock Restatement From Reverse Stock Split [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)				1,071,429
September 2022 Warrants [Member]
Warrants and Rights Outstanding | $			$ 1,400,000																	$ 500,000
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares			$ 0.18
TLF Bio Innovation 2021 Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)																									15,000
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares																									$ 0.6718
Warrants and Rights Outstanding, Term (Year)																									5 years
TLF Bio Innovation 2021 Warrants [Member] | Stock Restatement From Reverse Stock Split [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)																									429
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares																									$ 23.5130
The 2019 Domestic Warrants [Member]
Warrants and Rights Outstanding | $								$ 4,900,000				$ 3,100,000															$ 3,100,000
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares												$ 1.15
Payments of Stock Issuance Costs Allocated to Warrants | $												$ 200,000
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | $												$ 300,000
Class of Warrant or Right, Outstanding (in shares)	0																0
The 2019 Domestic Warrants [Member] | August 2019 Common Stock Purchase Agreement [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)												4,198,566
Class of Warrant or Right, Issued During Period (in shares)												4,198,566
The 2019 Foreign Warrants [Member]
Warrants and Rights Outstanding | $								4,200,000																			2,000,000.0
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares									$ 0.99
Exercise of Warrants, Commission, Percent									6.00%
Class of Warrant or Right, Outstanding (in shares)	0																0
New Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)																										6,898,566
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares																										$ 1.65
Warrants and Rights Outstanding, Term (Year)																										5 years 6 months
The 2019 Ladenburg Warrants [Member]
Warrants and Rights Outstanding | $								$ 200,000																			$ 100,000
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares									$ 0.99
Payments of Stock Issuance Costs | $																			300,000
Payments of Stock Issuance Costs Allocated to Warrants | $																			59,000
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | $																			$ 65,000
Class of Warrant or Right, Outstanding (in shares)	0																0
Class of Warrant or Right, Issued During Period (in shares)																			167,942
The 2019 Ladenburg Warrants [Member] | Stock Restatement From Reverse Stock Split [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares									$ 34.65
Class of Warrant or Right, Issued During Period (in shares)																			4,799
The June 2019 Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)													1,371,427
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares													$ 0.87
Proceeds from Warrant Exercises | $										$ 497	$ 199
Class of Warrant or Right, Issued During Period (in shares)													1,371,427
Class of Warrant or Right Call Feature Minimum Stock Price (in dollars per share) | $ / shares													$ 1.00
Class of Warrant or Right, Exercised During Period (in shares)										571,428	228,571
Class of Warrant or Right, Expired During Period (in shares)							571,428
The June 2019 Warrants [Member] | China Kington [Member]
Exercise of Warrants, Commission, Percent										6.00%	6.00%
Payments for Commission, Exercise of Warrants | $										$ 29	$ 12
October 2015 Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)														442,802
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares																								$ 5.00				$ 0.2061	$ 1.81
Proceeds from Warrant Exercises | $						$ 5,000
Class of Warrant or Right, Issued During Period (in shares)														442,802
Class of Warrant or Right, Exercised During Period (in shares)						22,680
Class of Warrant or Right, Expired During Period (in shares)								15,320
March 2015 Warrants [Member]
Class of Warrant or Right, Outstanding (in shares)	0																0
March 2015 Warrants [Member] | Minimum [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares															$ 15.00
March 2015 Warrants [Member] | Maximum [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares															$ 16.25
March 2015 Short-term and Long-term Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)															649,133
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares																												0.2061	1.81	$ 5.00
Proceeds from Warrant Exercises | $											$ 14,000
Class of Warrant or Right, Issued During Period (in shares)															649,133
Class of Warrant or Right, Exercised During Period (in shares)											70,000
Class of Warrant or Right, Expired During Period (in shares)											7,419
March 2015 Warrants Expiring March 6, 2020 [Member]
Class of Warrant or Right, Issued During Period (in shares)															278,200
March 2015 Warrants Expiring June 6, 2015 [Member]
Class of Warrant or Right, Issued During Period (in shares)															370,933
The July 2011 Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)																139,520
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares																$ 33.25												$ 0.2061	$ 1.81	$ 5.00
Class of Warrant or Right, Outstanding (in shares)	0																0
Class of Warrant or Right, Issued During Period (in shares)																139,520
Class of Warrant or Right, Expired During Period (in shares)					35,107
The July 2020 Warrants [Member]
Class of Warrant or Right, Outstanding (in shares)	0																0
Reverse Stock Split [Member]
Stockholders' Equity Note, Stock Split, Conversion Ratio		35

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- Definition

Amount of increase (decrease) in additional paid in capital (APIC) resulting from beneficial conversion feature upon issuance of stock.

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