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Note 12 - Stockholders' Equity (Details Textual) |  |  |  | 3 Months Ended | 12 Months Ended |  |  |  |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Nov. 15, 2022 $ / shares | Sep. 09, 2022 USD ($) $ / shares shares | Oct. 29, 2021 USD ($) $ / shares shares | Mar. 31, 2023 USD ($) $ / shares shares | Dec. 31, 2019 shares | Apr. 27, 2023 $ / shares | Dec. 31, 2022 $ / shares shares | Nov. 10, 2022 USD ($) | Sep. 08, 2022 USD ($) $ / shares | Jan. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Jan. 15, 2021 $ / shares shares | Sep. 30, 2020 $ / shares | Jul. 31, 2020 $ / shares
Common Stock, Shares Authorized (in shares) |  |  |  | 150,000,000 |  |  | 150,000,000 |  |  |  |  |  |  |
Preferred Stock, Shares Authorized (in shares) |  |  |  | 5,000,000 |  |  | 5,000,000 |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  | $ 7.70 |  |  | $ 7.70 |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) |  |  |  | 2,306,000 |  |  | 2,306,000 |  |  |  |  |  |  |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  | 0 |  |  |  |  |  |  |  |  |  |
The 2022 Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity, Total | $ |  | $ 3,200,000 |  |  |  |  |  |  |  |  |  |  |  |
The 2022 Private Placement [Member] | Conversion of Series C Preferred Stock to Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Shares Issuable (in shares) |  | 516,750 |  |  |  |  |  |  |  |  |  |  |  |
The 2021 Private Placement Program [Member] | Conversion of Series B Preferred Stock to Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted (in shares) |  |  |  | 3,380 |  |  |  |  |  |  |  |  |  |
The 2021 Private Placement Program [Member] | Conversion of Series B Preferred Stock to Common Stock [Member] | Stock Restatement From Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Shares Issuable (in shares) |  |  | 1,071,429 |  |  |  |  |  |  |  |  |  |  |
Series C Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  | 2,000 |  |  | 2,000 |  |  |  |  |  |  |
Series C Preferred Stock [Member] | The 2022 Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  | 3,250 |  |  |  |  |  |  |  |  |  |  |  |
Series B Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares | $ 6.30 | $ 0.18 |  |  |  |  |  |  | $ 0.40 |  |  |  |  |
Preferred Stock, Convertible, Conversion Ratio | 159 |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Preferred Stock, Shares Issued upon Conversion (in shares) |  | 5,556 |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Change in Conversion Price, Income Statement Impact | $ |  | $ 5,700,000 |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Fair Value Disclosure | $ |  | $ 12.5 |  |  |  |  |  |  | $ 6,800,000 |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  | 12,000 |  |  | 12,000 |  |  |  |  |  |  |
Series B Preferred Stock [Member] | The 2021 Private Placement Program [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) |  |  | 15,000 |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Preferred Stock and Preference Stock | $ |  |  | $ 14,900,000 |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Purchase Price (in dollars per share) | $ / shares |  |  | $ 1,000 |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares |  |  | $ 0.40 | $ 6.30 |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Ratio |  |  | 2,500 | 159 |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Outstanding, Ending Balance (in shares) |  |  |  | 11,620 |  |  |  |  |  |  |  |  |  |
Series B Preferred Stock [Member] | The 2021 Private Placement Program [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares |  |  |  |  |  | $ 1.30 |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Ratio |  |  |  |  |  | 770 |  |  |  |  |  |  |  |
The Amended November 2021 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 803,574 |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  | $ 3.5 |  |  |  |  |  |  |  |  |  |  |  |
The Amended July 2020 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 77,145 |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |
The July 2020 and November 2021 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  | $ 5,200,000 |  |  |  |  |  |  | $ 3,300,000 |  |  |  |  |
The 2022 Warrant Reprice Transaction [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 327,860 |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises | $ |  | $ 2,100,000 |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs | $ |  | 529,000 |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs Allocated to Warrants | $ |  | 166,000 |  |  |  |  |  |  |  |  |  |  |  |
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | $ |  | $ 363,000 |  |  |  |  |  |  |  |  |  |  |  |
The 2022 Warrant Reprice Transaction [Member] | Ladenburg Thalmann and Co. Inc. [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of Warrants, Commission, Percent |  | 8.00% |  |  |  |  |  |  |  |  |  |  |  |
The November 2021 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  |  |  |  |  |  |  | $ 1,300,000 |  | $ 7,500,000 | $ 9,600,000 |  |  |
Proceeds from Warrant Exercises | $ |  | $ 700,000 |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Outstanding (in shares) |  |  |  |  |  |  | 803,574 |  |  |  |  |  |  |
The November 2021 Warrants [Member] | Stock Restatement From Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |
Amended July 2020 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  | $ 300,000 |  | $ 100,000 |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises | $ |  | $ 1,400,000 |  |  |  |  |  |  |  |  |  |  |  |
The 2022 Private Placement Short Term Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 515,876 |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |
The 2022 Private Placement Long Term Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  | 515,876 |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  | $ 6.30 |  |  |  |  |  |  |  |  |  |  |  |
The 2021 Warrants [Member] | Stock Restatement From Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  | 1,071,429 |  |  |  |  |  |  |  |  |  |  |
September 2022 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  | $ 0.18 |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding | $ |  | $ 1,400,000 |  |  |  |  |  | $ 500,000 |  |  |  |  |  |
The 2019 Ladenburg Warrants [Member] | Stock Restatement From Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 34.65 |
Class of Warrant or Right, Issued During Period (in shares) |  |  |  |  | 4,799 |  |  |  |  |  |  |  |  |
The July 2020 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  | 59,960 |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 57.75
TLF Bio Innovation 2021 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) |  |  |  |  |  |  |  |  |  |  |  | 429 |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  | $ 23.513 |  |
Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio | 35 |  |  |  |  |  |  |  |  |  |  |  |  |

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