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Note 10 - Common Stock Warrants - Warrants Outstanding (Details) - $ / shares | Mar. 31, 2025 | Dec. 31, 2024 | Jul. 26, 2024 | Jun. 30, 2024 | May 31, 2024 | Mar. 31, 2024 | Dec. 31, 2023 | May 30, 2023 | Nov. 30, 2022 | Nov. 30, 2021 | Jul. 31, 2020
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Exercise price (in dollars per share) | $ 2.36 | $ 1.41 |  |  |  | $ 56.63 | $ 50.96 |  |  |  |
Warrants outstanding (in shares) | 4,753,613 | 10,836,275 |  |  |  | 239,518 | 210,946 |  |  |  |
The July 2020 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 2,021.25 |  |  |  |  |  |  |  |  |  | $ 2,021.25
Expiration date | Jan. 22, 2026 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 1,714 |  |  |  |  |  |  |  |  |  |
The Amended July 2020 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 52.5 |  |  |  |  |  |  | $ 52.5 |  |  |
Expiration date | Jan. 22, 2026 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 2,206 |  |  |  |  |  |  |  |  |  |
TLF Bio Innovation 2021 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 822.96 |  |  |  |  |  |  |  |  |  |
Expiration date | Jan. 15, 2026 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 13 |  |  |  |  |  |  |  |  |  |
The November 2021 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 220.5 |  |  |  |  |  |  |  |  | $ 649.25 |
Expiration date | Sep. 11, 2028 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 7,654 |  |  |  |  |  |  |  |  |  |
The Amended November 2021 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 52.5 |  |  |  |  |  |  |  |  |  |
Expiration date | Sep. 11, 2028 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 15,308 |  |  |  |  |  |  |  |  |  |
The September 2022 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 220.5 |  |  |  |  |  |  |  |  |  |
Expiration date | Sep. 11, 2028 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 2,552 |  |  |  |  |  |  |  |  |  |
The Amended September 2022 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 52.5 |  |  |  |  |  |  |  |  |  |
Expiration date | Sep. 11, 2028 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 1,715 |  |  |  |  |  |  |  |  |  |
The November 2022 A-1 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 220.5 |  |  |  | $ 52.5 |  |  |  | $ 220.5 |  |
Expiration date | Nov. 20, 2028 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 2,268 |  |  |  |  |  |  |  |  |  |
The December 2023 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 8.75 |  |  |  |  |  | $ 8.75 |  |  |  |
Expiration date | Jun. 21, 2029 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 72,256 |  |  |  |  |  |  |  |  |  |
March 2024 Warrant [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 4.9 |  |  |  |  | $ 4.9 |  |  |  |  |
Expiration date | Mar. 24, 2029 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 28,572 |  |  |  |  |  |  |  |  |  |
June 2024 Warrant [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 2.57 |  |  | $ 2.57 |  |  |  |  |  |  |
Expiration date | Dec. 17, 2029 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 90,381 |  |  |  |  |  |  |  |  |  |
Series F-1 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 0.66 |  | $ 1.1 |  |  |  |  |  |  |  |
Expiration date | Jul. 30, 2029 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 2,264,487 |  |  |  |  |  |  |  |  |  |
Series F-2 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) | $ 0.66 |  | $ 1.1 |  |  |  |  |  |  |  |
Expiration date | Jul. 29, 2025 |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 2,264,487 |  |  |  |  |  |  |  |  |  |

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