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Note 10 - Common Stock Warrants - Warrants Outstanding (Details) - $ / shares	Sep. 30, 2025	Dec. 31, 2024	Sep. 30, 2024	Jul. 26, 2024	Jun. 30, 2024	May 31, 2024	Dec. 31, 2023	May 30, 2023	Nov. 30, 2022	Nov. 30, 2021	Jul. 31, 2020
Exercise price (in dollars per share)	$ 66.61	$ 1.41	$ 56.63				$ 50.96
Warrants outstanding (in shares)	101,191	10,836,275	239,518				210,946
The July 2020 Warrants [Member]
Exercise price (in dollars per share)	$ 2,021.25										$ 2,021.25
Expiration date	Jan. 22, 2026
Warrants outstanding (in shares)	1,714
The Amended July 2020 Warrants [Member]
Exercise price (in dollars per share)	$ 52.5							$ 52.5
Expiration date	Jan. 22, 2026
Warrants outstanding (in shares)	2,206
TLF Bio Innovation 2021 Warrants [Member]
Exercise price (in dollars per share)	$ 822.96
Expiration date	Jan. 15, 2026
Warrants outstanding (in shares)	13
The November 2021 Warrants [Member]
Exercise price (in dollars per share)	$ 220.5									$ 649.25
Expiration date	Sep. 11, 2028
Warrants outstanding (in shares)	4,975
The Amended November 2021 Warrants [Member]
Exercise price (in dollars per share)	$ 52.5
Expiration date	Sep. 11, 2028
Warrants outstanding (in shares)	15,308
The September 2022 Warrants [Member]
Exercise price (in dollars per share)	$ 220.5
Expiration date	Sep. 11, 2028
Warrants outstanding (in shares)	1,659
The November 2022 A-1 Warrants [Member]
Exercise price (in dollars per share)	$ 220.5					$ 52.5			$ 220.5
Expiration date	Nov. 20, 2028
Warrants outstanding (in shares)	2,268
The December 2023 Warrants [Member]
Exercise price (in dollars per share)	$ 8.75						$ 8.75
Expiration date	Jun. 21, 2029
Warrants outstanding (in shares)	35,992
June 2024 Warrant [Member]
Exercise price (in dollars per share)	$ 2.57				$ 2.57
Expiration date	Dec. 17, 2029
Warrants outstanding (in shares)	22,556
Series F-1 Warrants [Member]
Exercise price (in dollars per share)	$ 0.66			$ 1.1
Expiration date	Jul. 30, 2029
Warrants outstanding (in shares)	14,500

X

- Definition

Exercise price per share or per unit of warrants or rights outstanding.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S50
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480738/235-10-S50-1

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(h)(4))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480678/235-10-S99-1

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-3

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- Definition

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+ References

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- Definition

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+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (bbb)(2)(i)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482106/820-10-50-2

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (bbb)(2)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482106/820-10-50-2

Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (bbb)(1)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482106/820-10-50-2

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