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Stockholders Equity (Tables)

3 Months Ended

Mar. 31, 2023

Stockholders' Equity Note [Abstract]

Schedule of outstanding warrants to purchase common stock issued to stockholders

Warrant

Issuance Date

Expiration Date

Exercise Price Per Share

Number of Shares of Common Stock Underlying Warrants

Private Placement Warrants

IPO (December 13, 2018)

December 13, 2023

11.50

2,900,000

Public Warrants

IPO (December 13, 2018)

October 28, 2024

11.50

3,500,000

2021 Registered Direct Offering Warrants

SPA (July 28, 2021)

January 28, 2027

5.00

2,812,501

Pre-Funded Warrants

February 27, 2023

0.001

2,776,428

11,988,929

Schedule of black-scholes option-pricing model

		Three Months Ended March 31,
		2023				2022
Underlying value of Common Stock ($)			0.40				1.41
Exercise price ($)			0.40				1.41
Expected volatility (%)			94.3				85.3
Expected terms of the option (years)			6.11				6.11
Risk-free interest rate (%)			4.21				2.50

Schedule of summary of options granted to purchase

		For the Three Months Ended March 31, 2023
		Number of Options				Weighted Average Exercise Price				Aggregate Intrinsic Value
Outstanding at the beginning of period			4,769,441			$	2.93			$	40
Granted			1,543,000			$	0.40
Forfeited			(197,841	)		$	3.16
Exercised			-			$	-
Outstanding at the end of period			6,114,600			$	2.28			$	67
Exercisable at the end of period			2,971,229			$	3.08
Weighted average remaining contractual life of outstanding options – years as of March 31, 2023			4.95

Schedule of outstanding compensation related warrants to purchase common stock

Warrant

Issuance Date

Expiration Date

Exercise Price Per Share

Number of Shares of Common Stock Underlying Warrants

Private Warrants issued to scientific founders (see below)

November 27, 2017

-

2,974

Schedule of share-based payment expenses

		Three Months Ended March 31,
		2023				2022
Research and development expenses, net			87				258
General and administrative			88				357
			175				615

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Tabular disclosure of the change in common stock outstanding.

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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Tabular disclosure of warrants or rights issued. Warrants and rights outstanding are derivative securities that give the holder the right to purchase securities (usually equity) from the issuer at a specific price within a certain time frame. Warrants are often included in a new debt issue to entice investors by a higher return potential. The main difference between warrants and call options is that warrants are issued and guaranteed by the company, whereas options are exchange instruments and are not issued by the company. Also, the lifetime of a warrant is often measured in years, while the lifetime of a typical option is measured in months. Disclose the title of issue of securities called for by warrants and rights outstanding, the aggregate amount of securities called for by warrants and rights outstanding, the date from which the warrants or rights are exercisable, and the price at which the warrant or right is exercisable.

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