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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Preferred Stock [Member] | Common Stock [Member] | Paid-In Capital [Member] | Accumulated Deficit [Member] | Total
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2016 |  | $ 22 | $ 222,513 | $ (211,300) | $ 11,235
Balance, shares at Dec. 31, 2016 |  | 2,280,407 |  |  |
Issuanceof common stock with offering, net of issuance costs |  | $ 8 | $ 3,120 |  | $ 3,128
Issuanceof common stock with offering, net of issuance costs, shares |  | 741,667 |  |  |
Round-up common shares issued in association with reverse stock split, shares |  | 5,991 |  |  |
Stock-based compensation |  |  | $ 219 |  | $ 219
Warrants issued in association with debt |  |  | 189 |  | 189
Net loss |  |  |  | (9,329) | (9,329)
Balance at Dec. 31, 2017 |  | $ 30 | 226,041 | (220,629) | 5,442
Balance, shares at Dec. 31, 2017 |  | 3,028,065 |  |  |
Stock-based compensation |  |  | 42 |  | 42
Warrants issued in association with debt |  |  | 98 |  | 98
Issuance of common stock upon exercise of warrants |  | $ 11 | 1,641 |  | 1,652
Issuance of common stock upon exercise of warrants, shares |  | 1,086,159 |  |  |
Issuance of common stock from the reduction in debt |  | $ 6 | 1,447 |  | 1,453
Issuance of common stock from the reduction in debt, shares |  | 580,444 |  |  |
Issuance of preferred stock from offering, net of issuance costs |  |  | 6,749 |  | 6,749
Issuance of preferred stock from offering, net of issuance costs, shares | 15,000 |  |  |  |
Issuance of common stock due to conversion of preferred stock |  | $ 171 | (171) |  |
Issuance of common stock due to conversion of preferred stock, shares | (10,926) | 17,098,973 |  |  |
Loss on extinguishment of derivative liability |  |  | 1,040 |  | 1,040
Deemed dividend related to adjustment of the exercise price of warrants issued with debt |  |  | (9) |  | (9)
Accretion of change in warrant exercise price |  |  | 9 |  | 9
Accretion of convertible preferred stock discount |  |  | 13,900 |  | 13,900
Deemed dividend related to the issuance of preferred stock |  |  | (13,900) |  | (13,900)
Extinguishment of derivative liability |  |  | 575 |  | 575
Net loss |  |  |  | (8,652) | (8,652)
Balance at Dec. 31, 2018 |  | $ 218 | $ 237,462 | $ (229,281) | $ 8,399
Balance, shares at Dec. 31, 2018 | 4,074 | 21,793,641 |  |  |

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