<SEC-DOCUMENT>0001179110-20-005048.txt : 20200423
<SEC-HEADER>0001179110-20-005048.hdr.sgml : 20200423
<ACCEPTANCE-DATETIME>20200423094354
ACCESSION NUMBER:		0001179110-20-005048
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20200421
FILED AS OF DATE:		20200423
DATE AS OF CHANGE:		20200423

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Schwartz Carl I.
		CENTRAL INDEX KEY:			0001573354

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36790
		FILM NUMBER:		20809566

	MAIL ADDRESS:	
		STREET 1:		20155 N.E. 38TH COURT, UNIT 3104
		CITY:			AVENTURA
		STATE:			FL
		ZIP:			33180

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Predictive Oncology Inc.
		CENTRAL INDEX KEY:			0001446159
		STANDARD INDUSTRIAL CLASSIFICATION:	ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]
		IRS NUMBER:				331007393
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2915 COMMERS DRIVE,
		STREET 2:		SUITE 900
		CITY:			EAGAN
		STATE:			MN
		ZIP:			55121
		BUSINESS PHONE:		651-389-4800

	MAIL ADDRESS:	
		STREET 1:		2915 COMMERS DRIVE,
		STREET 2:		SUITE 900
		CITY:			EAGAN
		STATE:			MN
		ZIP:			55121

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Precision Therapeutics Inc.
		DATE OF NAME CHANGE:	20180314

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Precision Therapeutic Inc.
		DATE OF NAME CHANGE:	20180208

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Skyline Medical Inc.
		DATE OF NAME CHANGE:	20130807
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 4 -
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2020-04-21</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001446159</issuerCik>
        <issuerName>Predictive Oncology Inc.</issuerName>
        <issuerTradingSymbol>POAI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001573354</rptOwnerCik>
            <rptOwnerName>Schwartz Carl I.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>3750 LAS VEGAS BLVD. SOUTH</rptOwnerStreet1>
            <rptOwnerStreet2>APT. 4303</rptOwnerStreet2>
            <rptOwnerCity>LAS VEGAS</rptOwnerCity>
            <rptOwnerState>NV</rptOwnerState>
            <rptOwnerZipCode>89158</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Executive Officer</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-04-21</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1533481</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.43</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1607911</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Shares issued pursuant to an Exchange Agreement by and between the Issuer and the Reporting Person in an exempt transaction under Rule 16b-3(d)(1), whereby the Reporting Person exchanged a promissory note for shares of the Issuer's common stock. The transaction was approved by the Audit Committee, which consists of Non-Employee Directors, and by the Board of Directors of the issuer.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Carl I. Schwartz, DDS</signatureName>
        <signatureDate>2020-04-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
