<SEC-DOCUMENT>0001178913-24-002709.txt : 20240820
<SEC-HEADER>0001178913-24-002709.hdr.sgml : 20240820
<ACCEPTANCE-DATETIME>20240820143644
ACCESSION NUMBER:		0001178913-24-002709
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20240820
DATE AS OF CHANGE:		20240820
GROUP MEMBERS:		SPHERA GLOBAL HEALTHCARE GP LTD.
GROUP MEMBERS:		SPHERA GLOBAL HEALTHCARE MANAGEMENT LP

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Chemomab Therapeutics Ltd.
		CENTRAL INDEX KEY:			0001534248
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				813676773
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-86953
		FILM NUMBER:		241224557

	BUSINESS ADDRESS:	
		STREET 1:		KIRYAT ATIDIM, BUILDING 7
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			6158002
		BUSINESS PHONE:		972-77-331-0156

	MAIL ADDRESS:	
		STREET 1:		KIRYAT ATIDIM, BUILDING 7
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			6158002

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Anchiano Therapeutics Ltd.
		DATE OF NAME CHANGE:	20180906

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BioCancell Ltd.
		DATE OF NAME CHANGE:	20111104

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SPHERA FUNDS MANAGEMENT LTD.
		CENTRAL INDEX KEY:			0001496201
		ORGANIZATION NAME:           	
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		4 ITZHAK SADE BUILDING A
		STREET 2:		29TH FLOOR
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			6777520
		BUSINESS PHONE:		972-3-6845535

	MAIL ADDRESS:	
		STREET 1:		4 ITZHAK SADE BUILDING A
		STREET 2:		29TH FLOOR
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			6777520
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>zk2431899.htm
<DESCRIPTION>SC 13G
<TEXT>
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Washington, D.C.&#160; 20549</div>
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    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">SCHEDULE 13G</div>
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;(Amendment No. )*</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 16pt; background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;"><u>Chemomab Therapeutics Ltd.</u></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">(Name of Issuer)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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    <div style="text-align: center; line-height: 1.25;">Ordinary shares, no par value</div>
    <div style="text-align: center; line-height: 1.25;"><u>American Depository Shares, each of which represents twenty ordinary shares, no par value</u></div>
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    <div style="text-align: center; line-height: 1.25;"><u>16385C104**</u></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">(CUSIP Number)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;"><u>July 25, 2024</u></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">(Date of Event Which Requires Filing of this Statement)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 28.35pt; line-height: 1.25;">&#9744; Rule 13d-1(b)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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    <div style="text-indent: 28.35pt; line-height: 1.25;">&#9746; Rule 13d-1(c)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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    <div style="text-indent: 28.35pt; line-height: 1.25;">&#9744; Rule 13d-1(d)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing
      information which would alter the disclosures provided in a prior cover page.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">**This CUSIP number applies to the American Depositary Shares (&#8220;ADSs&#8221;). No CUSIP number exists for the underlying ordinary shares.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">The information required in the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the <font style="font-style: italic;">Securities Exchange Act</font>
      of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
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            <div style="line-height: 1.25; font-weight: bold;">CUSIP No. 16385C104</div>
          </td>
          <td style="width: 35.42%; vertical-align: top;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">13G</div>
          </td>
          <td style="width: 28.04%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="line-height: 1.25; font-weight: bold;">Page 2 of 9 Pages</div>
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            <div style="text-align: center; line-height: 1.25; font-weight: bold;">1</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">NAME OF REPORTING PERSONS</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Sphera Funds Management Ltd.</div>
          </td>
        </tr>
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            <div style="text-align: center; line-height: 1.25; font-weight: bold;">2</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP&#160;&#160; (See instructions)</div>
            <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">(a)&#160; &#9744;</div>
            <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">(b)&#160; &#9746;</div>
          </td>
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          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">3</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SEC USE ONLY</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">4</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Israel</div>
          </td>
        </tr>
        <tr>
          <td rowspan="4" style="width: 9%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25;">NUMBER OF</div>
            <div style="text-align: center; line-height: 1.25;">SHARES</div>
            <div style="text-align: center; line-height: 1.25;">BENEFICIALLY</div>
            <div style="text-align: center; line-height: 1.25;">OWNED BY</div>
            <div style="text-align: center; line-height: 1.25;">EACH</div>
            <div style="text-align: center; line-height: 1.25;">REPORTING</div>
            <div style="text-align: center; line-height: 1.25;">PERSON WITH</div>
          </td>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">5</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SOLE VOTING POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">--</div>
          </td>
        </tr>
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          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">6</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SHARED VOTING POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">1,214,575 (*)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">7</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SOLE DISPOSITIVE POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">--</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">8</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SHARED DISPOSITIVE POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">1,214,575 (*)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">9</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">1,214,575 (*)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">10</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)</div>
            <div style="margin-right: 30pt; line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#9744; <br>
              </font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">11</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">6.56% (*) (**)</div>
          </td>
        </tr>
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          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">12</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">TYPE OF REPORTING PERSON&#160;&#160; (See instructions)</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">CO</div>
          </td>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">(*) The beneficial ownership of the securities reported herein is described in Item 4(a).</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">(**) Based on 18,508,057 ADSs outstanding as of July 25, 2024 (as provided by the Issuer).</div>
    <div style="line-height: 1.25;"> <br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">2</font></div>
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            <div style="line-height: 1.25; font-weight: bold;">CUSIP No. 16385C104</div>
          </td>
          <td style="width: 35.42%; vertical-align: top;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">13G</div>
          </td>
          <td style="width: 28.04%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="line-height: 1.25; font-weight: bold;">Page 3 of 9 Pages</div>
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            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">1</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">NAME OF REPORTING PERSONS</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Sphera Global Healthcare GP Ltd.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">2</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP&#160;&#160; (See instructions)</div>
            <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">(a)&#160; &#9744;</div>
            <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">(b)&#160; &#9746;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">3</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SEC USE ONLY</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">4</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Israel</div>
          </td>
        </tr>
        <tr>
          <td rowspan="4" style="width: 9%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25;">NUMBER OF</div>
            <div style="text-align: center; line-height: 1.25;">SHARES</div>
            <div style="text-align: center; line-height: 1.25;">BENEFICIALLY</div>
            <div style="text-align: center; line-height: 1.25;">OWNED BY</div>
            <div style="text-align: center; line-height: 1.25;">EACH</div>
            <div style="text-align: center; line-height: 1.25;">REPORTING</div>
            <div style="text-align: center; line-height: 1.25;">PERSON WITH</div>
          </td>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; font-weight: bold;">5</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SOLE VOTING POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">--</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; font-weight: bold;">6</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SHARED VOTING POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">&#160;1,214,575 (*)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; font-weight: bold;">7</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SOLE DISPOSITIVE POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">--</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; font-weight: bold;">8</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SHARED DISPOSITIVE POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">&#160;1,214,575 (*)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">9</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">1,214,575 (*)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">10</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)</div>
            <div style="margin-right: 30pt; line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="line-height: 1.25;">&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">11</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">6.56% (*) (**)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">12</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">TYPE OF REPORTING PERSON&#160;&#160; (See instructions)</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">CO</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">(*) The beneficial ownership of the securities reported herein is described in Item 4(a).</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">(**) Based on 18,508,057 ADSs outstanding as of July 25, 2024 (as provided by the Issuer).</div>
    <div style="line-height: 1.25;"> <br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">3</font></div>
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-align: justify; line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zfda381128d75469ead022b9eb6cd99ed">

        <tr>
          <td style="width: 36.54%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="line-height: 1.25; font-weight: bold;">CUSIP No. 16385C104</div>
          </td>
          <td style="width: 35.42%; vertical-align: top;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">13G</div>
          </td>
          <td style="width: 28.04%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="line-height: 1.25; font-weight: bold;">Page 4 of 9 Pages</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">1</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">NAME OF REPORTING PERSONS</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Sphera Global Healthcare Management LP</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">2</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP&#160;&#160; (See instructions)</div>
            <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">(a)&#160; &#9744;</div>
            <div style="text-indent: -290.6pt; margin-right: 30pt; margin-left: 299.35pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">(b)&#160; &#9746;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">3</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SEC USE ONLY</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">4</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Israel</div>
          </td>
        </tr>
        <tr>
          <td rowspan="4" style="width: 9%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25;">NUMBER OF</div>
            <div style="text-align: center; line-height: 1.25;">SHARES</div>
            <div style="text-align: center; line-height: 1.25;">BENEFICIALLY</div>
            <div style="text-align: center; line-height: 1.25;">OWNED BY</div>
            <div style="text-align: center; line-height: 1.25;">EACH</div>
            <div style="text-align: center; line-height: 1.25;">REPORTING</div>
            <div style="text-align: center; line-height: 1.25;">PERSON WITH</div>
          </td>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">5</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SOLE VOTING POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">--</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">6</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SHARED VOTING POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">&#160;1,214,575 (*)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">7</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SOLE DISPOSITIVE POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">--</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">8</div>
          </td>
          <td style="width: 82%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">SHARED DISPOSITIVE POWER</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">1,214,575 (*)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">9</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">&#160;1,214,575 (*)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">10</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)</div>
            <div style="margin-right: 30pt; line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="line-height: 1.25;">&#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">11</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">6.56% (*) (**)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman', Times, serif; font-weight: bold;">12</div>
          </td>
          <td colspan="2" style="vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">TYPE OF REPORTING PERSON (See instructions)</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="margin-right: 30pt; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">PN</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">(*) The beneficial ownership of the securities reported herein is described in Item 4(a).</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">(**) Based on 18,508,057ADSs outstanding as of July 25, 2024 (as provided by the Issuer).</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">4</font></div>
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-align: center; line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z51924a4e628a4eb1818c51434dedc770">

        <tr>
          <td style="width: 78pt; vertical-align: top;"><font style="font-weight: bold;">Item 1.</font> (a)</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Name of Issuer</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 28.35pt; margin-left: 49.65pt; line-height: 1.25;">Chemomab Therapeutics Ltd.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z0aef3d4771d8440884a32f1cfe7a4209">

        <tr>
          <td style="width: 78pt; vertical-align: top;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Address of Issuer's Principal Executive Offices</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;">Kiryat Atidim, Building 7, Tel Aviv 6158002, Israel</div>
    <div style="text-indent: 28.35pt; margin-left: 49.65pt; line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z1d2a7d94350141869ccee7cd088c9ad1">

        <tr>
          <td style="width: 78pt; vertical-align: top;"><font style="font-weight: bold;">Item 2.</font> (a)</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Name of Person Filing</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;">Sphera Funds Management Ltd.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;">Sphera Global Healthcare GP Ltd.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;">Sphera Global Healthcare Management LP</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z9377a84fafaf434781158f741d469a33">

        <tr>
          <td style="width: 45.8pt;"><br>
          </td>
          <td style="width: 32.2pt; vertical-align: top;">(b)</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Address of Principal Business Office</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Funds Management Ltd. &#8211; 4 Itzak Sade, Building A, 29<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor, Tel Aviv 6777504, Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare GP Ltd. &#8211; 4 Itzak Sade, Building A, 29<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor, Tel Aviv 6777504, Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare Management LP &#8211; 4 Itzak Sade, Building A, 29<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor, Tel Aviv 6777504, Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z7529e6c54e0c4d328fdb97bdfa15f8d8">

        <tr>
          <td style="width: 45.8pt;"><br>
          </td>
          <td style="width: 32.2pt; vertical-align: top;">(c)</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Citizenship</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Funds Management Ltd. &#8211; Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare GP Ltd. &#8211; Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare Management LP &#8211; Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zf5226be77eed4f81af9255877a66da14">

        <tr>
          <td style="width: 45.8pt;"><br>
          </td>
          <td style="width: 32.2pt; vertical-align: top;">(d)</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Title of Class of Securities</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">American Depository Shares, each of which represents twenty ordinary shares, no par value</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zc6061303784f49daa2c4dc036ef533a2">

        <tr>
          <td style="width: 45.75pt;"><br>
          </td>
          <td style="width: 32.25pt; vertical-align: top;">(e)</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>CUSIP Number</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">16385C104</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb361793448204781b548ad44194d3e2f">

        <tr>
          <td style="width: 78pt; vertical-align: top;"><font style="font-weight: bold;">Item 3</font>.</td>
          <td style="width: auto; vertical-align: top;">
            <div>Not applicable.</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">5</font></div>
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z7e635c5216fe4d4880a294ff3ab3f1c2">

        <tr>
          <td style="width: 78pt; vertical-align: top;"><font style="font-weight: bold;">Item 4</font>.</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Ownership</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z859bed0f6e7040d6bc5fed2be8e7c1ea">

        <tr>
          <td style="width: 42.55pt;"><br>
          </td>
          <td style="width: 35.45pt; vertical-align: top;">(a)</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Amount beneficially owned</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">See row 9 of cover page of each reporting person.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">The securities reported herein by Sphera Funds Management Ltd., Sphera Global Healthcare GP Ltd. and Sphera Global Healthcare Management LP are beneficially owned
      as follows:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zf941899bfde7473ba73861f5fdfb16b7">

        <tr>
          <td style="width: 78pt;"><br>
          </td>
          <td style="width: 13.6pt; vertical-align: top;">&#8226;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>1,214,575 ADSs, representing a total of 6.56% of the total ADSs outstanding, are held directly by Sphera Biotech Master Fund, which has delegated its investment management authority to Sphera Global Healthcare Management LP (the "<u>Management


                Company</u>").</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">The Management Company is managed, controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd., the shares of which are owned 90% by Sphera
      Funds Management Ltd.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; margin-left: 78pt; line-height: 1.25;">This Statement shall not be construed as an admission by any of the Reporting Persons that it is the beneficial owner of any of the securities covered by this Statement, and each
      Reporting Person disclaims beneficial ownership of any such securities.&#160;In addition, the Reporting Persons and other entities named in this Schedule 13G may be deemed to constitute a "group" for purposes of Section 13(d) of the Securities Exchange
      Act of 1934. Neither the filing of this Schedule 13G nor any of its contents shall be deemed to constitute an admission that a group exists for purposes of Section 13(d) of the Securities Exchange Act of 1934 or for any other purpose, and each of the
      Reporting Persons and other entities named in this Schedule 13G disclaims the existence of any such group.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z582c83b82861490797af60625cda91de">

        <tr>
          <td style="width: 42.55pt;"><br>
          </td>
          <td style="width: 35.25pt; vertical-align: top;">(b)</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Percent of class</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">See row 11 of cover page of each reporting person</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z239b5a11f1064567b78513d40919f537">

        <tr>
          <td style="width: 42.55pt;"><br>
          </td>
          <td style="width: 35.45pt; vertical-align: top;">(c)</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Number of shares as to which such person has</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="za3a7f524bee04af1b71f1e556250017f">

        <tr>
          <td style="width: 77.8pt;"><br>
          </td>
          <td style="width: 28.55pt; vertical-align: top;">(i)</td>
          <td style="width: auto; vertical-align: top;">
            <div>Sole power to vote or to direct the vote:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 106.35pt; line-height: 1.25;">See row 5 of cover page of each reporting person</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z39ec2729556044129765caa519ec9ee9">

        <tr>
          <td style="width: 77.8pt;"><br>
          </td>
          <td style="width: 28.55pt; vertical-align: top;">(ii)</td>
          <td style="width: auto; vertical-align: top;">
            <div>Shared power to vote or to direct the vote:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 106.35pt; line-height: 1.25;">See row 6 of cover page of each reporting person and note in Item 4(a) above</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb8557456d3c2456eb9fc6a038a125fad">

        <tr>
          <td style="width: 77.8pt;"><br>
          </td>
          <td style="width: 28.55pt; vertical-align: top;">(iii)</td>
          <td style="width: auto; vertical-align: top;">
            <div>Sole power to dispose or to direct the disposition of:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 106.35pt; line-height: 1.25;">See row 7 of cover page of each reporting person</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z44f1f9a04ccf48a19b7f8a964546a43d">

        <tr>
          <td style="width: 77.8pt;"><br>
          </td>
          <td style="width: 28.55pt; vertical-align: top;">(iv)</td>
          <td style="width: auto; vertical-align: top;">
            <div>Shared power to dispose or to direct the disposition of:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 106.35pt; line-height: 1.25;">See row 8 of cover page of each reporting person and note in Item 4(a) above</div>
    <div style="margin-left: 106.35pt; line-height: 1.25;"> <br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">6</font></div>
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z4c0a4dee4fda4e84ae9c9c447406ea42">

        <tr>
          <td style="width: 78pt; vertical-align: top;"><font style="font-weight: bold;">Item 5</font>.</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Ownership of Five Percent or Less of a Class</u>:</div>
          </td>
        </tr>

    </table>
    <div style="text-indent: -78pt; margin-left: 78pt; line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z15a9af87e80a4c1e94d5dbece74afc23">

        <tr>
          <td style="width: 78pt; vertical-align: top;"><font style="font-weight: bold;">Item 6</font>.</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Ownership of More than Five Percent on Behalf of Another</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z0095d8647d7441e3938dfc09d0975169">

        <tr>
          <td style="width: 78pt; vertical-align: top;"><font style="font-weight: bold;">Item 7</font>.</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zd8dc0b1cce9b491db8208102f956b415">

        <tr>
          <td style="width: 78pt; vertical-align: top;"><font style="font-weight: bold;">Item 8</font>.</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Identification and Classification of Members of the Group</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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        <tr>
          <td style="width: 78pt; vertical-align: top;"><font style="font-weight: bold;">Item 9</font>.</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Notice of Dissolution of Group</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
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        <tr>
          <td style="width: 78pt; vertical-align: top; font-weight: bold;">Item 10.</td>
          <td style="width: auto; vertical-align: top;">
            <div><u>Certification</u>:</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 35.45pt; line-height: 1.25;">By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the
      effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.</div>
    <div style="text-align: justify; text-indent: 35.45pt; line-height: 1.25;"> <br>
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    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u> </u></div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">7</font></div>
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    <div style="text-align: center; line-height: 1.25;">&#160;<font style="font-weight: bold;">SIGNATURE</font></div>
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    </div>
    <div style="text-indent: 35.45pt; line-height: 1.25;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">August 20, 2024</div>
    <div style="line-height: 1.25">&#160;</div>
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        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
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            <div style="line-height: 1.25;"><font style="font-weight: bold;">Sphera Funds Management Ltd.</font><br>
              <br>
              <u>/s/ Oshrat Levi</u></div>
            <div style="line-height: 1.25;">By: Oshrat Levi<br>
              Title: CFO</div>
            <div style="line-height: 1.25;"> <br>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="font-weight: bold;">Sphera Global Healthcare GP Ltd.</font><br style="line-height: 1.25;">
                <br>
                <u>/s/ Oshrat Levi</u><br>
                By: Oshrat Levi<br>
                Title: CFO</div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="font-weight: bold;">Sphera Global Healthcare Management LP</font><br style="line-height: 1.25;">
                <br>
                <u>/s/ Oshrat Levi</u><br>
                By: Oshrat Levi<br>
                Title: CFO</div>
            </div>
          </td>
        </tr>

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    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">8</font></div>
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        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">EXHIBIT NO.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">DESCRIPTION</font></div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
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          <td style="width: 56.7pt; vertical-align: top;"><a href="exhibit_1.htm">Exhibit 1</a></td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div><a href="exhibit_1.htm">Joint Filing Agreement by and among the Reporting Persons</a></div>
          </td>
        </tr>

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    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25"> <br>
    </div>
    <div style="line-height: 1.25; text-align: center;">9<br>
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      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"> </div>
    <div style="line-height: 1.25"> <br>
    </div>
    <br>
  </div>
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</TEXT>
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<DOCUMENT>
<TYPE>EX-99
<SEQUENCE>2
<FILENAME>exhibit_1.htm
<DESCRIPTION>EXHIBIT 1
<TEXT>
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  <head>
    <title></title>
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <div style="line-height: 1.25;">
      <div style="text-align: right; line-height: 1.25; font-weight: bold;"><u> </u>
        <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
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      <div style="text-align: right; line-height: 1.25; font-weight: bold;"><u>Exhibit 1</u></div>
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      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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    <div style="line-height: 1.25;">
      <div style="text-align: center; line-height: 1.25;"><u>Joint Filing Agreement</u></div>
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      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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      <div style="text-align: justify; text-indent: 27pt; line-height: 1.25;">Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree
        that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of shares of&#160;Chemomab Therapeutics Ltd.; each of them is responsible for the timely filing of such
        Schedule 13G and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the information concerning the other
        persons making the filing, unless such person knows or has reason to believe that such information is inaccurate.&#160;In accordance with Rule 13d-1(k)(1), the undersigned hereby agree to the joint filing with each other on behalf of each of them of
        such a statement on Schedule 13G and any amendments thereto with respect to the equity securities (as defined in Rule 13d-1(i)) of the Issuer, beneficially owned by each of them. This Joint Filing Agreement shall be included as an exhibit to such
        Schedule 13G and any amendments thereto.</div>
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    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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      <div style="text-align: justify; text-indent: 27pt; line-height: 1.25;">This agreement may be executed in any number of counterparts, each of which shall be deemed an original.</div>
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    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25;">August 20, 2024</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">
            <div style="line-height: 1.25;"><font style="font-weight: bold;">Sphera Funds Management Ltd.</font><br>
              <font style="font-family: 'Times New Roman',Times,serif;"><br>
              <u>/s/ Oshrat Levi</u><br>
              </font></div>
            <div style="line-height: 1.25;">By: Oshrat Levi<br>
              Title: CFO</div>
            <div style="line-height: 1.25;"> <br>
            </div>
            <div style="line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">Sphera Global Healthcare GP
                Ltd.</font><font style="font-family: 'Times New Roman',Times,serif;"><br>
              <br>
              <u>/s/ Oshrat Levi</u><br>
              </font>By: Oshrat Levi<font style="font-family: 'Times New Roman',Times,serif;"><br>
              </font>Title: CFO
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="font-weight: bold;">Sphera Global
                  Healthcare Management LP</font><br>
                <br>
                <u>/s/ Oshrat Levi</u><br>
                By: Oshrat Levi<br>
                Title: CFO</div>
            </div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
    <div style="line-height: 1.25">&#160;</div>
    <br>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
  </div>
</body>
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