<SEC-DOCUMENT>0001209191-17-049646.txt : 20170818
<SEC-HEADER>0001209191-17-049646.hdr.sgml : 20170818
<ACCEPTANCE-DATETIME>20170818171734
ACCESSION NUMBER:		0001209191-17-049646
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		<ITEMS>06b
FILED AS OF DATE:		20170818
DATE AS OF CHANGE:		20170818
EFFECTIVENESS DATE:		20170818

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RXi Pharmaceuticals Corp
		CENTRAL INDEX KEY:			0001533040
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-293158
		FILM NUMBER:		171041702

	BUSINESS ADDRESS:	
		STREET 1:		257 SIMARANO DRIVE
		STREET 2:		SUITE 101
		CITY:			MARLBOROUGH
		STATE:			MA
		ZIP:			01752
		BUSINESS PHONE:		(508) 767-3861

	MAIL ADDRESS:	
		STREET 1:		257 SIMARANO DRIVE
		STREET 2:		SUITE 101
		CITY:			MARLBOROUGH
		STATE:			MA
		ZIP:			01752
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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<edgarSubmission>

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    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001533040</cik>
        <entityName>RXi Pharmaceuticals Corp</entityName>
        <issuerAddress>
            <street1>257 Simarano Drive</street1>
            <street2>Suite 101</street2>
            <city>Marlborough</city>
            <stateOrCountry>MA</stateOrCountry>
            <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
            <zipCode>01752</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(508) 767-3861</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Geert</firstName>
                <lastName>Cauwenbergh</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o RXi Pharmaceutials Corporation</street1>
                <street2>257 Simarano Drive, Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gerrit</firstName>
                <lastName>Dispersyn</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o RXi Pharmaceuticals Corporation</street1>
                <street2>257 Simarano Drive, Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alexey</firstName>
                <lastName>Eliseev</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o RXi Pharmaceuticals Corporation</street1>
                <street2>257 Simarano Drive, Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Bitterman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o RXi Pharmaceuticals Corporation</street1>
                <street2>257 Simarano Drive, Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Keith</firstName>
                <lastName>Brownlie</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o RXi Pharmaceuticals Corporation</street1>
                <street2>257 Simarano Drive, Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Paul</firstName>
                <lastName>Dorman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o RXi Pharmaceuticals Corporation</street1>
                <street2>257 Simarano Drive, Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jonathan</firstName>
                <lastName>Freeman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o RXi Pharmaceuticals Corporation</street1>
                <street2>257 Simarano Drive, Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Curtis</firstName>
                <lastName>Lockshin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o RXi Pharmaceuticals Corporation</street1>
                <street2>257 Simarano Drive, Suite 10</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2017-08-08</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>15261000</totalOfferingAmount>
            <totalAmountSold>261000</totalAmountSold>
            <totalRemaining>15000000</totalRemaining>
            <clarificationOfResponse>450,000 shares issued to LPC on 8/8/17 as initial consideration for put right granted to RXi under equity line; valued for purposes of this form at $0.58/share (closing stock price on 8/8/17 on NASDAQ Capital Market).</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>RXi Pharmaceuticals Corporation</issuerName>
                <signatureName>Geert Cauwenbergh</signatureName>
                <nameOfSigner>Geert Cauwenbergh</nameOfSigner>
                <signatureTitle>President and CEO</signatureTitle>
                <signatureDate>2017-08-18</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
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</SEC-DOCUMENT>
