<SEC-DOCUMENT>0001567619-22-020839.txt : 20221123
<SEC-HEADER>0001567619-22-020839.hdr.sgml : 20221123
<ACCEPTANCE-DATETIME>20221123160037
ACCESSION NUMBER:		0001567619-22-020839
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		<ITEMS>06b
FILED AS OF DATE:		20221123
DATE AS OF CHANGE:		20221123
EFFECTIVENESS DATE:		20221123

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Phio Pharmaceuticals Corp.
		CENTRAL INDEX KEY:			0001533040
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-465775
		FILM NUMBER:		221416268

	BUSINESS ADDRESS:	
		STREET 1:		257 SIMARANO DRIVE
		STREET 2:		SUITE 101
		CITY:			MARLBOROUGH
		STATE:			MA
		ZIP:			01752
		BUSINESS PHONE:		(508) 767-3861

	MAIL ADDRESS:	
		STREET 1:		257 SIMARANO DRIVE
		STREET 2:		SUITE 101
		CITY:			MARLBOROUGH
		STATE:			MA
		ZIP:			01752

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RXi Pharmaceuticals Corp
		DATE OF NAME CHANGE:	20111019
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
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    <primaryIssuer>
        <cik>0001533040</cik>
        <entityName>Phio Pharmaceuticals Corp.</entityName>
        <issuerAddress>
            <street1>257 Simarano Drive</street1>
            <street2>Suite 101</street2>
            <city>Marlborough</city>
            <stateOrCountry>MA</stateOrCountry>
            <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
            <zipCode>01752</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(508) 767-3861</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>RXi Pharmaceuticals Corp.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>RXi Pharmaceuticals Corp</previousName>
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        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
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    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <middleName>J.</middleName>
                <lastName>Bitterman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>257 Simarano Drive</street1>
                <street2>Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Patricia</firstName>
                <middleName>A.</middleName>
                <lastName>Bradford</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>257 Simarano Drive</street1>
                <street2>Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
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            <relatedPersonRelationshipList>
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        </relatedPersonInfo>
        <relatedPersonInfo>
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                <firstName>Geert</firstName>
                <lastName>Cauwenbergh</lastName>
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                <street1>257 Simarano Drive</street1>
                <street2>Suite 101</street2>
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                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
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        <relatedPersonInfo>
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                <middleName>L.</middleName>
                <lastName>Ferrara</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>257 Simarano Drive</street1>
                <street2>Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
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            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
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                <firstName>Jonathan</firstName>
                <middleName>E.</middleName>
                <lastName>Freeman</lastName>
            </relatedPersonName>
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                <street2>Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
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                <zipCode>01752</zipCode>
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            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Curtis</firstName>
                <middleName>A.</middleName>
                <lastName>Lockshin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>257 Simarano Drive</street1>
                <street2>Suite 101</street2>
                <city>Marlborough</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>01752</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2022-11-16</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>1750</totalOfferingAmount>
            <totalAmountSold>1750</totalAmountSold>
            <totalRemaining>0</totalRemaining>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Phio Pharmaceuticals Corp.</issuerName>
                <signatureName>/s/ Robert J. Bitterman</signatureName>
                <nameOfSigner>Robert J. Bitterman</nameOfSigner>
                <signatureTitle>Executive Chair</signatureTitle>
                <signatureDate>2022-11-23</signatureDate>
            </signature>
        </signatureBlock>
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</DOCUMENT>
</SEC-DOCUMENT>
