<SEC-DOCUMENT>0001683168-25-006986.txt : 20250915
<SEC-HEADER>0001683168-25-006986.hdr.sgml : 20250915
<ACCEPTANCE-DATETIME>20250915160203
ACCESSION NUMBER:		0001683168-25-006986
CONFORMED SUBMISSION TYPE:	4/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250911
FILED AS OF DATE:		20250915
DATE AS OF CHANGE:		20250915

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Ferrara Robert L
		CENTRAL INDEX KEY:			0001792987
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36304
		FILM NUMBER:		251314310

	MAIL ADDRESS:	
		STREET 1:		257 SIMARANO DRIVE, SUITE 101
		CITY:			MARLBOROUGH
		STATE:			MA
		ZIP:			01752

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Phio Pharmaceuticals Corp.
		CENTRAL INDEX KEY:			0001533040
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				453215903
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		411 SWEDELAND ROAD
		STREET 2:		SUITE 23-1080
		CITY:			KING OF PRUSSIA
		STATE:			PA
		ZIP:			19406
		BUSINESS PHONE:		(508) 767-3861

	MAIL ADDRESS:	
		STREET 1:		411 SWEDELAND ROAD
		STREET 2:		SUITE 23-1080
		CITY:			KING OF PRUSSIA
		STATE:			PA
		ZIP:			19406

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RXi Pharmaceuticals Corp
		DATE OF NAME CHANGE:	20111019
</SEC-HEADER>
<DOCUMENT>
<TYPE>4/A
<SEQUENCE>1
<FILENAME>ownership.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2025-09-11</periodOfReport>

    <dateOfOriginalSubmission>2025-09-15</dateOfOriginalSubmission>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001533040</issuerCik>
        <issuerName>Phio Pharmaceuticals Corp.</issuerName>
        <issuerTradingSymbol>PHIO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001792987</rptOwnerCik>
            <rptOwnerName>Ferrara Robert L</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O PHIO PHARMACEUTICALS CORP.</rptOwnerStreet1>
            <rptOwnerStreet2>411 SWEDELAND RD., STE 23-1080</rptOwnerStreet2>
            <rptOwnerCity>KING OF PRUSSIA</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>19406</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, $.0001 par value</value>
            </securityTitle>
            <transactionDate>
                <value>2025-09-11</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness></transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>23100</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F4"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>38766</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Represents shares underlying a restricted stock unit, which shares will vest on the first annual anniversary of the grant.</footnote>
        <footnote id="F2">Includes shares of common stock underlying unvested restricted stock units.</footnote>
        <footnote id="F3">The number of reported securities has been adjusted to reflect prior reverse stock splits.</footnote>
        <footnote id="F4">This amended Form 4 corrects the number of stock options reported in the original Form 4 filed on September 15, 2025. The original filing incorrectly stated that 23,000 restricted stock units were granted. The correct number of restricted stock units granted was 23,100. Securities beneficially owned changed from 38,666 to 38,766.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Lisa C. Carson, Attorney-in-fact</signatureName>
        <signatureDate>2025-09-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
