<SEC-DOCUMENT>0001415889-22-000715.txt : 20220121
<SEC-HEADER>0001415889-22-000715.hdr.sgml : 20220121
<ACCEPTANCE-DATETIME>20220121204118
ACCESSION NUMBER:		0001415889-22-000715
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20220121
FILED AS OF DATE:		20220121
DATE AS OF CHANGE:		20220121

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Guarino Jonathan L.
		CENTRAL INDEX KEY:			0001787282

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14778
		FILM NUMBER:		22547250

	MAIL ADDRESS:	
		STREET 1:		100 WELLESLEY WAY
		CITY:			FREEHOLD
		STATE:			NJ
		ZIP:			07728

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SOLIGENIX, INC.
		CENTRAL INDEX KEY:			0000812796
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				411505029
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		29 EMMONS DRIVE
		STREET 2:		SUITE B-10
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08540
		BUSINESS PHONE:		609-538-8200

	MAIL ADDRESS:	
		STREET 1:		29 EMMONS DRIVE
		STREET 2:		SUITE B-10
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08540

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	DOR BIOPHARMA INC
		DATE OF NAME CHANGE:	20020329

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ENDOREX CORP
		DATE OF NAME CHANGE:	19960916

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	IMMUNOTHERAPEUTICS INC
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>form4-01212022_050109.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-01-21</periodOfReport>

    <issuer>
        <issuerCik>0000812796</issuerCik>
        <issuerName>SOLIGENIX, INC.</issuerName>
        <issuerTradingSymbol>SNGX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001787282</rptOwnerCik>
            <rptOwnerName>Guarino Jonathan L.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SOLIGENIX, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>29 EMMONS DRIVE, SUITE B-10</rptOwnerStreet2>
            <rptOwnerCity>PRINCETON</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>08540</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>CHIEF FINANCIAL OFFICER</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Option (Right to Buy)</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.78</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2022-01-21</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>50000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2021-12-09</value>
            </exerciseDate>
            <expirationDate>
                <value>2031-12-08</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>50000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>50000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The terms of the stock option provide that it is to vest immediately as to 12,500 shares and to vest as to the remainder at a rate of 3,125 of the shares every three months, beginning on March 12, 2022; provided, however, that, consistent with the 2015 Equity Incentive Plan (the &quot;Plan&quot;) and the rules of the Nasdaq Stock Market, such stock option shall not be exercisable nor shall it vest prior to the time when an amendment increasing the number of shares authorized for issuance under the Plan is approved by the stockholders, and provided further that, if such approval has not been obtained within 12 months of the grant date, the stock option shall thereupon be canceled and become null and void. The reporting person voluntarily agreed to cancel the stock option granted December 9, 2021 with respect to 50,000 shares.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Jonathan L. Guarino</signatureName>
        <signatureDate>2022-01-21</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
