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v3.25.2

Consolidated Statements of Cash Flows - USD ($) | 6 Months Ended | 12 Months Ended
--- | --- | ---
Jun. 30, 2025 | Jun. 30, 2024 | Dec. 31, 2024 | Dec. 31, 2023
Operating activities: |  |  |  |
Net loss | $ (5,653,244) | $ (3,559,829) | $ (8,266,576) | $ (6,140,730)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |
Amortization and depreciation | 1,311 | 3,176 | 5,814 | 6,554
Non-cash lease expense | 60,263 | 59,155 | 120,871 | 111,153
Share-based compensation | 163,112 | 117,636 | 329,815 | 370,182
Issuance of common stock to vendors for services | 30,000 |  | 15,800 | 73,000
Issuance of common stock for purchase option |  |  |  | 50,000
Loss on extinguishment of debt |  |  |  | 393,791
Change in fair value of convertible debt |  | (260,933) | (260,933) | (43,066)
Amortization of deferred issuance costs associated with convertible debt |  |  |  | 12,518
Change in operating assets and liabilities: |  |  |  |
Contracts and grants receivable |  | 171,254 | 171,254 | (56,124)
Prepaid expenses and other current assets | 714,169 | 621,542 | (39,255) | (591,805)
Research and development incentives receivable |  | 48,994 | 48,643 | 90,016
Operating lease liability | (61,062) | (59,344) | (121,765) | (108,948)
Accounts payable and accrued expenses | 405,869 | (231,089) | (492,613) | (2,685,073)
Accrued compensation | (249,253) | (170,871) | 85,327 | (85,577)
Net cash flows from operating activities | (4,588,835) | (3,260,309) | (8,403,618) | (8,604,109)
Investing activities: |  |  |  |
Purchases of office furniture and equipment | (3,313) |  |  |
Net cash flows from investing activities | (3,313) |  |  |
Financing activities: |  |  |  |
Proceeds from issuance of common stock pursuant to At Market Issuance Sales Agreement | 3,243,177 |  | 1,071,559 | 3,091,462
Proceeds from issuance of common stock and pre-funded warrants |  | 4,741,400 | 4,741,400 | 8,495,817
Issuance costs associated with issuance of common stock |  | (524,226) |  |
Proceeds from the exercise of warrants |  | 8,600 |  |
Proceeds from the exercise of warrants |  |  | 4,450,172 | 3,299
Issuance costs associated with warrant inducement |  |  | (374,774) |
Convertible debt repayments | (1,372,873) |  | (1,372,872) | (7,000,000)
Net cash flows from financing activities | 1,870,304 | 4,225,774 | 7,762,089 | 3,663,506
Effect of exchange rate on cash and cash equivalents |  | 916 | 14,885 | 27,146
Net increase (decrease) in cash and cash equivalents | (2,721,844) | 966,381 | (626,644) | (4,913,457)
Cash and cash equivalents at beginning of year | 7,819,514 | 8,446,158 | 8,446,158 | 13,359,615
Cash and cash equivalents at end of year | 5,097,670 | 9,412,539 | 7,819,514 | 8,446,158
Supplemental information: |  |  |  |
Cash paid for state income taxes | 89,557 | 33,665 | 42,162 | 20,730
Cash paid for interest | 35,044 | 125,286 | 227,735 | 552,058
Cash paid for lease liabilities: |  |  |  |
Operating lease | 69,750 | 68,200 | 136,917 | 133,817
Non-cash investing and financing activities: |  |  |  |
Pontifax conversion of portion of debt principal into common stock |  | 254,256 | 254,256 |
Right-of-use assets obtained in exchange for lease liabilities | 360,604 |  |  |
Deferred issuance cost reclassified to additional paid-in capital | $ 72,165 |  | 250,698 | 20,208
Offering costs included in accounts payable |  | $ 100,839 |  |
Redemption liability for Series D preferred stock |  |  |  | 43
Warrant modification - incremental value |  |  | 7,177,683 |
At Market Issuance Sales Agreement |  |  |  |
Financing activities: |  |  |  |
Issuance costs associated with issuance of common stock |  |  | (128,331) | (93,011)
Public Offering |  |  |  |
Financing activities: |  |  |  |
Issuance costs associated with issuance of common stock |  |  | $ (625,065) | $ (834,061)

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