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v3.25.2

Income Taxes - Schedule of federal and state statutory tax rates and the provision for income tax benefit (Details) | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023
Income Taxes |  |
Federal tax at statutory rate | (21.00%) | (21.00%)
State tax benefits, plus sale of NJ NOL, net of federal benefit | (12.20%) | (21.60%)
Foreign tax rate difference |  | 0.10%
Orphan drug and research and development credits | (8.10%) | (2.00%)
Permanent differences | 1.30% | 0.90%
Foreign NOL adjustments | 0.60% | 0.70%
Expiration of tax attributes | 15.20% | 14.20%
Change in valuation allowance | 19.50% | 6.30%
Income tax benefit | (4.70%) | (22.40%)

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- Definition Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 55 -Paragraph 231 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482663/740-10-55-231 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12A -Subparagraph (a)(6) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12A Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12 Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 235 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(h)(2)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480678/235-10-S99-1 + Details
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