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Consolidated Statements of Changes in Equity and Shareholders' Equity (Deficit) - USD ($) | Preferred Stock Series D Preferred Stock | Common Stock Public Offering | Common Stock At Market Issuance sales | Common Stock Pre-funded warrants | Common Stock Existing Warrants | Common Stock New Warrants | Common Stock | Additional Paid-In Capital Public Offering | Additional Paid-In Capital At Market Issuance sales | Additional Paid-In Capital Pre-funded warrants | Additional Paid-In Capital Existing Warrants | Additional Paid-In Capital New Warrants | Additional Paid-In Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit | Public Offering | At Market Issuance sales | Pre-funded warrants | Existing Warrants | New Warrants | Total
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2022 |  |  |  |  |  |  | $ 182 |  |  |  |  |  | $ 217,067,691 | $ 24,747 | $ (219,563,446) |  |  |  |  |  | $ (2,470,826)
Balance (in shares) at Dec. 31, 2022 |  |  |  |  |  |  | 181,898 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Balance at Dec. 31, 2022 | $ 43 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock pursuant to At Market Issuance Sales Agreement |  |  | $ 53 |  |  |  |  |  | $ 3,091,409 |  |  |  |  |  |  |  | $ 3,091,462 |  |  |  |
Issuance of common stock pursuant to At Market Issuance Sales Agreement (in shares) |  |  | 53,202 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock in public offering |  | $ 144 |  |  |  |  |  | $ 8,495,673 |  |  |  |  |  |  |  | $ 8,495,817 |  |  |  |  |
Issuance of common stock in public offering (in shares) |  | 143,844 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with sales of common stock |  |  |  |  |  |  |  | (834,061) | (113,217) |  |  |  |  |  |  | (834,061) | (113,217) |  |  |  |
Issuance of common stock to vendors |  |  |  |  |  |  | $ 3 |  |  |  |  |  | 72,997 |  |  |  |  |  |  |  | 73,000
Issuance of common stock to vendors (in shares) |  |  |  |  |  |  | 3,125 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock for purchase option |  |  |  |  |  |  | $ 2 |  |  |  |  |  | 49,998 |  |  |  |  |  |  |  | 50,000
Issuance of common stock for purchase option (in shares) |  |  |  |  |  |  | 1,978 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of pre-funded warrants |  |  |  |  |  |  | $ 265 |  |  |  |  |  | 3,034 |  |  |  |  |  |  |  | 3,299
Issuance of common stock upon exercise of pre-funded warrants (in shares) |  |  |  |  |  |  | 264,714 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation expense |  |  |  |  |  |  |  |  |  |  |  |  | 370,182 |  |  |  |  |  |  |  | 370,182
Foreign currency translation adjustment |  |  |  |  |  |  |  |  |  |  |  |  |  | (2,504) |  |  |  |  |  |  | (2,504)
Net loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (6,140,730) |  |  |  |  |  | (6,140,730)
Balance at Dec. 31, 2023 |  |  |  |  |  |  | $ 649 |  |  |  |  |  | 228,203,706 | 22,243 | (225,704,176) |  |  |  |  |  | $ 2,522,422
Balance (in shares) at Dec. 31, 2023 |  |  |  |  |  |  | 648,761 |  |  |  |  |  |  |  |  |  |  |  |  |  | 648,761
Balance (in Shares) at Dec. 31, 2023 |  |  |  |  |  |  | 648,761 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Redemption of Series D preferred stock | (43) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock in reverse stock split |  |  |  |  |  |  | $ 115 |  |  |  |  |  | (115) |  |  |  |  |  |  |  |
Issuance of common stock in reverse stock split (in shares) |  |  |  |  |  |  | 114,735 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock in public offering |  |  |  |  |  |  | $ 205 |  |  |  |  |  | 4,741,195 |  |  |  |  |  |  |  | $ 4,741,400
Issuance of common stock in public offering (in shares) |  |  |  |  |  |  | 204,694 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with sales of common stock |  |  |  |  |  |  |  |  |  |  |  |  | (625,065) |  |  |  |  |  |  |  | (625,065)
Issuance of common stock associated with conversion of debt |  |  |  |  |  |  | $ 36 |  |  |  |  |  | 254,220 |  |  |  |  |  |  |  | 254,256
Issuance of common stock associated with conversion of debt (in shares) |  |  |  |  |  |  | 36,790 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of pre-funded warrants |  |  |  |  |  |  | $ 537 |  |  |  |  |  | 8,063 |  |  |  |  |  |  |  | 8,600
Issuance of common stock upon exercise of pre-funded warrants (in shares) |  |  |  |  |  |  | 537,500 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation expense |  |  |  |  |  |  |  |  |  |  |  |  | 117,636 |  |  |  |  |  |  |  | 117,636
Foreign currency translation adjustment |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,356 |  |  |  |  |  |  | 5,356
Net loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (3,559,829) |  |  |  |  |  | (3,559,829)
Balance at Jun. 30, 2024 |  |  |  |  |  |  | $ 1,542 |  |  |  |  |  | 232,699,640 | 27,599 | (229,264,005) |  |  |  |  |  | 3,464,776
Balance (in shares) at Jun. 30, 2024 |  |  |  |  |  |  | 1,542,480 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Balance at Dec. 31, 2023 |  |  |  |  |  |  | $ 649 |  |  |  |  |  | 228,203,706 | 22,243 | (225,704,176) |  |  |  |  |  | $ 2,522,422
Balance (in shares) at Dec. 31, 2023 |  |  |  |  |  |  | 648,761 |  |  |  |  |  |  |  |  |  |  |  |  |  | 648,761
Balance (in shares) at Dec. 31, 2023 |  |  |  |  |  |  | 648,761 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock pursuant to At Market Issuance Sales Agreement |  |  | $ 229 |  |  |  |  |  | 1,071,330 |  |  |  |  |  |  |  | 1,071,559 |  |  |  |
Issuance of common stock pursuant to At Market Issuance Sales Agreement (in shares) |  |  | 229,078 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock in reverse stock split |  |  |  |  |  |  | $ 115 |  |  |  |  |  | (115) |  |  |  |  |  |  |  |
Issuance of common stock in reverse stock split (in shares) |  |  |  |  |  |  | 114,735 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock in public offering |  | $ 205 |  |  |  |  |  | 4,741,195 |  |  |  |  |  |  |  | 4,741,400 |  |  |  |  |
Issuance of common stock in public offering (in shares) |  | 204,694 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with sales of common stock |  |  |  |  |  |  |  | $ (625,065) | $ (24,484) |  |  |  |  |  |  | $ (625,065) | $ (24,484) |  |  |  |
Issuance of common stock to vendors |  |  |  |  |  |  | $ 5 |  |  |  |  |  | 15,795 |  |  |  |  |  |  |  | $ 15,800
Issuance of common stock to vendors (in shares) |  |  |  |  |  |  | 5,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock associated with conversion of debt |  |  |  |  |  |  | $ 36 |  |  |  |  |  | 254,220 |  |  |  |  |  |  |  | 254,256
Issuance of common stock associated with conversion of debt (in shares) |  |  |  |  |  |  | 36,790 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of pre-funded warrants |  |  |  | $ 537 | $ 703 | $ 35 |  |  |  | $ 8,063 | $ 4,218,047 | $ 222,787 |  |  |  |  |  | $ 8,600 | $ 4,218,750 | $ 222,822 |
Issuance of common stock upon exercise of pre-funded warrants (in shares) |  |  |  | 537,500 | 703,125 | 34,816 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation expense |  |  |  |  |  |  |  |  |  |  |  |  | 329,815 |  |  |  |  |  |  |  | 329,815
Foreign currency translation adjustment |  |  |  |  |  |  |  |  |  |  |  |  |  | 23,546 |  |  |  |  |  |  | 23,546
Net loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (8,266,576) |  |  |  |  |  | (8,266,576)
Balance at Dec. 31, 2024 |  |  |  |  |  |  | $ 2,514 |  |  |  |  |  | 238,040,520 | 45,789 | (233,970,752) |  |  |  |  |  | $ 4,118,071
Balance (in shares) at Dec. 31, 2024 |  |  |  |  |  |  | 2,514,499 |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,514,499
Balance (in Shares) at Dec. 31, 2024 |  |  |  |  |  |  | 2,514,499 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Balance at Dec. 31, 2024 | $ 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with warrant inducement |  |  |  |  |  |  |  |  |  |  |  |  | (7,552,457) |  |  |  |  |  |  |  | $ (7,552,457)
Warrant modification - incremental fair value |  |  |  |  |  |  |  |  |  |  |  |  | 7,177,683 |  |  |  |  |  |  |  | 7,177,683
Balance at Mar. 31, 2024 |  |  |  |  |  |  | $ 658 |  |  |  |  |  | 228,363,074 | 24,143 | (227,619,503) |  |  |  |  |  | 768,372
Balance (in shares) at Mar. 31, 2024 |  |  |  |  |  |  | 657,900 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock in reverse stock split |  |  |  |  |  |  | $ 115 |  |  |  |  |  | (115) |  |  |  |  |  |  |  |
Issuance of common stock in reverse stock split (in shares) |  |  |  |  |  |  | 114,735 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock in public offering |  |  |  |  |  |  | $ 205 |  |  |  |  |  | 4,741,195 |  |  |  |  |  |  |  | 4,741,400
Issuance of common stock in public offering (in shares) |  |  |  |  |  |  | 204,694 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with sales of common stock |  |  |  |  |  |  |  |  |  |  |  |  | (625,065) |  |  |  |  |  |  |  | (625,065)
Issuance of common stock associated with conversion of debt |  |  |  |  |  |  | $ 27 |  |  |  |  |  | 154,813 |  |  |  |  |  |  |  | 154,840
Issuance of common stock associated with conversion of debt (in shares) |  |  |  |  |  |  | 27,651 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of pre-funded warrants |  |  |  |  |  |  | $ 537 |  |  |  |  |  | 8,063 |  |  |  |  |  |  |  | 8,600
Issuance of common stock upon exercise of pre-funded warrants (in shares) |  |  |  |  |  |  | 537,500 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation expense |  |  |  |  |  |  |  |  |  |  |  |  | 57,675 |  |  |  |  |  |  |  | 57,675
Foreign currency translation adjustment |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,456 |  |  |  |  |  |  | 3,456
Net loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (1,644,502) |  |  |  |  |  | (1,644,502)
Balance at Jun. 30, 2024 |  |  |  |  |  |  | $ 1,542 |  |  |  |  |  | 232,699,640 | 27,599 | (229,264,005) |  |  |  |  |  | 3,464,776
Balance (in shares) at Jun. 30, 2024 |  |  |  |  |  |  | 1,542,480 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Balance at Dec. 31, 2024 |  |  |  |  |  |  | $ 2,514 |  |  |  |  |  | 238,040,520 | 45,789 | (233,970,752) |  |  |  |  |  | $ 4,118,071
Balance (in shares) at Dec. 31, 2024 |  |  |  |  |  |  | 2,514,499 |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,514,499
Issuance of common stock pursuant to At Market Issuance Sales Agreement |  |  |  |  |  |  | $ 979 |  |  |  |  |  | 3,242,198 |  |  |  |  |  |  |  | $ 3,243,177
Issuance of common stock pursuant to At Market Issuance Sales Agreement (in shares) |  |  | 978,105 |  |  |  | 978,105 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with sales of common stock |  |  |  |  |  |  |  |  |  |  |  |  | (72,165) |  |  |  |  |  |  |  | (72,165)
Issuance of common stock to vendors |  |  |  |  |  |  | $ 12 |  |  |  |  |  | 29,988 |  |  |  |  |  |  |  | 30,000
Issuance of common stock to vendors (in shares) |  |  |  |  |  |  | 12,346 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of pre-funded warrants (in shares) |  |  |  |  |  | 12,346 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation expense |  |  |  |  |  |  |  |  |  |  |  |  | 163,112 |  |  |  |  |  |  |  | 163,112
Net loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (5,653,244) |  |  |  |  |  | (5,653,244)
Balance at Jun. 30, 2025 |  |  |  |  |  |  | $ 3,505 |  |  |  |  |  | 241,403,653 | 45,789 | (239,623,996) |  |  |  |  |  | $ 1,828,951
Balance (in shares) at Jun. 30, 2025 |  |  |  |  |  |  | 3,504,950 |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,504,950
Balance at Mar. 31, 2025 |  |  |  |  |  |  | $ 3,183 |  |  |  |  |  | 240,770,981 | 45,789 | (236,922,020) |  |  |  |  |  | $ 3,897,933
Balance (in shares) at Mar. 31, 2025 |  |  |  |  |  |  | 3,183,992 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock pursuant to At Market Issuance Sales Agreement |  |  |  |  |  |  | $ 322 |  |  |  |  |  | 545,313 |  |  |  |  |  |  |  | 545,635
Issuance of common stock pursuant to At Market Issuance Sales Agreement (in shares) |  |  |  |  |  |  | 320,958 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance costs associated with sales of common stock |  |  |  |  |  |  |  |  |  |  |  |  | (12,154) |  |  |  |  |  |  |  | (12,154)
Share-based compensation expense |  |  |  |  |  |  |  |  |  |  |  |  | 99,513 |  |  |  |  |  |  |  | 99,513
Net loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (2,701,976) |  |  |  |  |  | (2,701,976)
Balance at Jun. 30, 2025 |  |  |  |  |  |  | $ 3,505 |  |  |  |  |  | $ 241,403,653 | $ 45,789 | $ (239,623,996) |  |  |  |  |  | $ 1,828,951
Balance (in shares) at Jun. 30, 2025 |  |  |  |  |  |  | 3,504,950 |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,504,950

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