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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 6 Months Ended
--- | ---
Jun. 30, 2018 | Jun. 30, 2017
Cash flows from operating activities: |  |
Net loss | $ (12,707,551) | $ (10,050,005)
Non-cash items included in net loss: |  |
Depreciation and amortization | 174,342 | 341,058
Change in fair value of earn-out milestone liability | 547,324 | 575,979
Deferred revenue | (250,000) | (250,000)
Stock-based compensation costs | 3,371,301 | 804,592
Restricted shares issued | 29,841 |
Amortization of deferred finance charges and debt discount associated with notes payable | 4,237 | 35,370
Change in deferred rent liability | (2,955) | 24,488
Net changes in: |  |
Accrued interest on investment securities | (2,392) | 4,008
Advances, deposits and other current assets | (12,000) | 94,461
Accounts payable and accrued liabilities | 35,776 | 1,093,740
Net cash (used in) operating activities: | (8,812,077) | (7,326,309)
Cash flows from investing activities: |  |
Purchases of investment securities | (5,712,170) |
Proceeds from sale and maturity of investment securities | 5,000,000 | 1,680,000
Refund (deposit) on corporate office lease | (50,000) | 100,000
Purchases of property and equipment | (77,698) | (21,126)
Net cash (used in) provided by investing activities | (839,868) | 1,758,874
Cash flows from financing activities: |  |
Proceeds from sale of common stock equity, net of issuance costs | 1,236,584 | 4,252,948
Proceeds from notes payable, net of issuance costs | 9,725,000 |
Proceeds from exercise of common stock warrants |  | 4,915,286
Principal payments on notes payable |  | (2,595,923)
Net cash provided by financing activities | 10,961,584 | 6,572,311
Increase in cash and cash equivalents | 1,309,639 | 1,004,876
Cash and cash equivalents at beginning of period | 11,444,055 | 2,624,162
Cash and cash equivalents at end of period | 12,753,694 | 3,629,038
Supplemental disclosures of cash flow information: |  |
Interest paid | 10,794 | 56,386
Non-cash investing and financing activities: |  |
Fair value of warrants issued in connection with the notes payable | $ 507,116 |

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