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v3.10.0.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 9 Months Ended
--- | ---
Sep. 30, 2018 | Sep. 30, 2017
Cash flows from operating activities: |  |
Net loss | $ (17,363,937) | $ (15,721,334)
Non-cash items included in net loss: |  |
Depreciation and amortization | 261,513 | 511,587
Change in fair value of earn-out milestone liability | (3,567,671) | (670,172)
Impairment of in-process research and development | 4,510,000 | 2,520,000
Recognition of deferred revenue | (375,000) | (375,000)
Stock-based compensation costs | 3,985,829 | 951,488
Restricted shares issued | 29,841 |
Amortization of deferred finance charges and debt discount associated with notes payable | 101,695 | 35,370
Change in deferred rent liability | (6,009) | 61,328
Net changes in: |  |
Accrued interest on investment securities | (22,306) | 4,008
Advances, deposits and other current assets | (231,991) | 115,106
Accounts payable and accrued liabilities | (399,935) | 134,440
Net cash (used in) operating activities: | (13,077,971) | (12,433,179)
Cash flows from investing activities: |  |
Purchases of investment securities | (15,574,587) |
Proceeds from sale and maturity of investment securities | 9,750,000 | 1,680,000
(Deposit) refund on corporate office lease | (50,000) | 100,000
Purchases of property and equipment | (81,778) | (21,126)
Net cash (used in) provided by investing activities | (5,956,365) | 1,758,874
Cash flows from financing activities: |  |
Proceeds from sale of common stock equity, net of issuance costs | 1,236,584 | 8,405,190
Proceeds from notes payable, net of issuance costs | 9,725,000 |
Proceeds from exercise of common stock warrants |  | 4,925,886
Principal payments on notes payable |  | (2,595,923)
Net cash provided by financing activities | 10,961,584 | 10,735,153
(Decrease) increase in cash and cash equivalents | (8,072,752) | 60,848
Cash and cash equivalents at beginning of period | 11,444,055 | 2,624,162
Cash and cash equivalents at end of period | 3,371,303 | 2,685,010
Supplemental disclosures of cash flow information: |  |
Interest paid | 259,064 | 56,386
Non-cash financing activities: |  |
Fair value of common stock issued as equity issuance costs and charged against paid in capital | 450,000 |
Fair value of warrants issued in connection with notes payable | 507,116 |
Total non-cash financing activites | $ 957,116 |

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