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Consolidated Statements of Changes in Stockholders' Equity - USD ($) | Common Stock [Member] | Additional Paid in Capital [Member] | Treasury Stock [Member] | Accumulated Other Comprehensive Income [Member] | Accumulated Deficit [Member] | Total
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2016 | $ 22,305 | $ 248,168,421 | $ (85,188) |  | $ (241,379,712) | $ 6,725,826
Balance, shares at Dec. 31, 2016 | 2,230,118 |  | 334 |  |  |
Net loss |  |  |  |  | (20,402,176) | (20,402,176)
Registered direct and ATM common stock offerings | $ 72,964 | 17,837,437 |  |  |  | 17,910,401
Registered direct and ATM common stock offerings, shares | 7,296,352 |  |  |  |  |
Exercise of common stock warrants | $ 76,171 | 21,064,133 |  |  |  | 21,140,304
Exercise of common stock warrants, shares | 7,617,148 |  |  |  |  |
Shares issued to satisfy certain obligations | $ 1,301 | 233,771 |  |  |  | 235,072
Shares issued to satisfy certain obligations, shares | 130,055 |  |  |  |  |
Realized and unrealized gains and losses, net, on investments securities |  |  |  | (10,164) |  | (10,164)
Stock-based compensation expense |  | 1,105,245 |  |  |  | 1,105,245
Issuance of restricted stock | $ 34 | (34) |  |  |  |
Issuance of restricted stock, shares | 3,357 |  |  |  |  |
Modification of warrant exercise prices |  | 345,685 |  |  |  | 345,685
Deemed dividend related to warrant exercise price modifications |  | (345,685) |  |  |  | (345,685)
Effect of reverse stock split | $ (3) | 3 |  |  |  |
Effect of reverse stock split, shares | (65) |  |  |  |  |
Balance at Dec. 31, 2017 | $ 172,772 | 288,408,976 | $ (85,188) | (10,164) | (261,781,888) | 26,704,508
Balance, shares at Dec. 31, 2017 | 17,276,965 |  | 334 |  |  |
Net loss |  |  |  |  | (11,883,359) | (11,883,359)
Realized and unrealized gains and losses, net, on investments securities |  |  |  | 40,036 |  | 40,036
Stock-based compensation expense |  | 4,604,415 |  |  |  | 4,604,415
Issuance of restricted stock | $ 123 | 29,718 |  |  |  | 29,841
Issuance of restricted stock, shares | 12,250 |  |  |  |  |
Sale of equity through ATM and common stock purchase agreement | $ 5,572 | 983,528 |  |  |  | 989,100
Sale of equity through ATM and common stock purchase agreement, shares | 557,070 |  |  |  |  |
Common stock issuance in exchange for cancellation of common stock warrants | $ 8,207 | (138,792) |  |  |  | (130,585)
Common stock issuance in exchange for cancellation of common stock warrants, shares | 820,714 |  |  |  |  |
Common stock and warrants to purchase common stock issued in connection with equity and debt facilities | $ 1,648 | 505,468 |  |  |  | 507,116
Common stock and warrants to purchase common stock issued in connection with equity and debt facilities, shares | 164,835 |  |  |  |  |
Balance at Dec. 31, 2018 | $ 188,322 | $ 294,393,313 | $ (85,188) | $ 29,872 | $ (273,665,247) | $ 20,861,072
Balance, shares at Dec. 31, 2018 | 18,831,834 |  | 334 |  |  |

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