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Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017
Cash flows from operating activities: |  |
Net loss | $ (11,883,359) | $ (20,402,176)
Non-cash items included in net loss: |  |
Depreciation and amortization | 356,859 | 553,010
Change in fair value of earn-out milestone liability | (3,630,861) | (649,701)
Impairment of in-process research and development | 4,510,000 | 2,520,000
Stock-based compensation | 4,604,415 | 1,105,245
Shares issued in exchange for services | 29,841 |
Shares issued to satisfy certain obligations |  | 235,072
Amortization of deferred finance charges and debt discount associated with note payable | 199,153 | 35,370
Change in deferred rent liability | (8,432) | 59,358
Net changes in: |  |
Interest receivable on investments | (13,869) | (50,432)
Advances and deposits on clinical programs and other current assets | (362,107) | 115,222
Other assets | (250,172) |
Accounts payable - trade | (396,225) | 537,885
Deferred revenue | (500,000) | (500,000)
Other accrued liabilities | 303,071 | (200,929)
Net cash used in operating activities | (7,041,686) | (16,642,076)
Cash flows from investing activities: |  |
Purchases of investment securities | (16,973,942) | (12,734,184)
Proceeds from sale and maturity of investment securities | 15,480,000 | 1,680,000
Refund on security for letter of credit |  | 100,000
Purchases of property and equipment | (138,399) | (38,629)
Net cash (used in) provided by investing activities | (1,632,341) | (10,992,813)
Cash flows from financing activities: |  |
Proceeds from issuance of common stock equity, net of issuance costs | 858,515 | 17,910,401
Proceeds from note payable, net of issuance costs | 9,725,000 |
Proceeds from exercise of common stock warrants |  | 21,140,304
Principal payments on note payable |  | (2,595,923)
Net cash provided by financing activities | 10,583,515 | 36,454,782
Increase in cash and cash equivalents | 1,909,488 | 8,819,893
Cash and cash equivalents at beginning of period | 11,444,055 | 2,624,162
Cash and cash equivalents at end of period | 13,353,543 | 11,444,055
Cash (paid for) received from: |  |
Interest paid | (512,872) | (56,386)
Income tax benefit | 10,419,115 |
Non-cash financing activities: |  |
Fair value of common stock issued as equity issuance costs charged against paid in capital | 450,000 |
Fair value of common stock and warrants issued in connection with notes payable | 507,116 |
Fair value of stock issued in exchange for cancelation of warrants | 8,207 |
Fair value of modification of warrant exercise prices included in paid in capital |  | 345,685
Fair value of deemed dividend related to modification of warrant exercise prices charged against paid in capital |  | $ (345,685)

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- Definition The cash outflow for a borrowing supported by a written promise to pay an obligation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
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- Definition The fair value of stock issued in noncash financing activities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4304-108586 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4332-108586 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4313-108586 + Details
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- References No definition available. + Details
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