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Licenses of Intellectual Property and Patents (Details Textual) | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2018 USD ($) Trademark shares | Dec. 31, 2017 USD ($) shares | Jan. 31, 2003 USD ($) shares
Common stock, shares, issued | shares | 18,832,168 | 17,277,299 |
Common stock, value, issued | $ | $ 188,322 | $ 172,772 |
Number of trademark protection application pending for thermo dox | Trademark | 14 |  |
License Agreement [Member] | Duke University [Member] |  |  |
Number of days before issuance factoring into average closing price | 20 days |  |
Amount of time after effective date of license agreement for registration rights to take place | 1 year |  |
Common stock, shares, issued | shares |  |  | 253,691
Common stock, value, issued | $ |  |  | $ 2,200,000

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