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Stock-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Summary of Stock Option Awards

A summary of stock option awards as of December 31, 2018 and changes during the two-year period ended December 31, 2018 is presented below:

 

Stock Options   Number Outstanding     Weighted Average Exercise Price     Weighted Average Remaining Contractual Term (years)     Aggregate Intrinsic Value  
Outstanding at January 1, 2017     211,213     $ 61.59                  
Granted     535,964     $ 2.69                  
Canceled or expired     (43,735 )   $ 164.12                  
Outstanding at December 31, 2017     703,442     $ 10.34                  
Granted     2,629,004     $ 2.26                  
Canceled or expired     (183,703 )   $ 25.96                  
Outstanding at December 31, 2018     3,148,743     $ 2.67       9.2     $ -  
                                 
Exercisable at December 31, 2018     1,689,902     $ 2.97       9.1     $ -  
Summary of Non-vested Restricted Stock Awards

A summary of the status of the Company’s non-vested restricted stock awards as of December 31, 2018 and changes during the two year period ended December 31, 2018, is presented below:

 

Restricted Stock  

Number

Outstanding

    

Weighted

Average

Grant Date

Fair Value

  
Non-vested stock awards outstanding at January 1, 2017     4,785     $ 37.42  
Granted     (3,357 )   $ 42.20  
Vested and issued     (1,428 )   $ 26.18  
Non-vested stock awards outstanding at December 31, 2017     -     $ -  
Granted     35,000     $ 2.71  
Vested and issued     (6,000 )   $ 2.77  
Forfeited     (6,500 )   $ 2.64  
Non-vested stock awards outstanding at December 31, 2018     22,500     $ 2.72  
Summary of Stock Options Outstanding

A summary of stock options outstanding at December 31, 2018 by price range is as follows:

 

    Options Outstanding     Options Exercisable  
             
Range of Exercise Prices     Number      

Weighted Average Remaining Contractual Term

(in years)

       Weighted Average Exercise Price       Number      

Weighted Average Remaining Contractual Term

(in years)

       Weighted Average Exercise Price  
                                                 
Up to $5.00     3,084,252       9.2     $ 2.34       1,625,807       9.2     $ 2.34  
Above $5.00 to $81.90     64,491       7.0     $ 19.00       64,095       7.0     $ 19.00  
      3,148,743                       1,689,902                  
Schedule of Assumptions Used to Determine Fair Value of Options Granted

The model is also sensitive to changes in assumptions, which can materially affect the fair value estimate. The Company used the following assumptions for determining the fair value of options granted under the Black-Scholes option pricing model:

 

    Year Ended December 31,  
    2018     2017  
Risk-free interest rate     2.82 to 3.02 %     2.21 to 2.32 %
Expected volatility     99.9 - 102.12 %     90.4 - 100.8 %
Expected life (in years)     8.5  to 10       10  
Expected dividend yield     0.0 %     0.0 %