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Stock-Based Compensation - Schedule of Stock Option Awards and Restricted Stock Grants (Details) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Number Outstanding, Ending Balance	3,148,743
Number Outstanding, Exercisable	1,689,902
Stock Options [Member]
Number Outstanding, Outstanding, Beginning Balance	703,442	211,213
Number Outstanding, Granted	2,629,004	535,964
Number Outstanding, Cancelled or expired	(183,703)	(43,735)
Number Outstanding, Ending Balance	3,148,743	703,442
Number Outstanding, Exercisable	1,689,902
Weighted Average Exercise Price, Outstanding, Beginning Balance	$ 10.34	$ 61.59
Weighted Average Exercise Price, Granted	2.26	2.69
Weighted Average Exercise Price, Cancelled or expired	25.96	164.12
Weighted Average Exercise Price, Outstanding, Ending Balance	2.67	$ 10.34
Weighted Average Exercise Price, Excercisable	$ 2.97
Weighted Average Remaining Contractual Term (years), Outstanding, Ending Balance	9 years 2 months 12 days
Weighted Average Remaining Contractual Term (years), Exercisable	9 years 1 month 6 days
Aggregate Intrinsic Value, Outstanding, Ending Balance
Aggregate Intrinsic Value, Exercisable

X

- Definition

The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

+ References

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-SubTopic 10
-Section 50
-Paragraph 2
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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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- Definition

For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired.

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Weighted average price of options that were either forfeited or expired.

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Net number of share options (or share units) granted during the period.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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