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Licenses of Intellectual Property and Patents (Details Textual)
 12 Months Ended
Dec. 31, 2018
USD ($)
Trademark
shares
Dec. 31, 2017
USD ($)
shares
Jan. 31, 2003
USD ($)
shares
Common stock, shares, issued | shares 18,832,168 17,277,299  
Common stock, value, issued | $ $ 188,322 $ 172,772  
Number of trademark protection application pending for thermo dox | Trademark 14    
License Agreement [Member] | Duke University [Member]      
Number of days before issuance factoring into average closing price 20 days    
Amount of time after effective date of license agreement for registration rights to take place 1 year    
Common stock, shares, issued | shares     253,691
Common stock, value, issued | $     $ 2,200,000