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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
Common Stock [Member]
Additional Paid in Capital [Member]
Treasury Stock [Member]
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit [Member]
Total
Balance at Dec. 31, 2016 $ 22,305 $ 248,168,421 $ (85,188) $ (241,379,712) $ 6,725,826
Balance, shares at Dec. 31, 2016 2,230,118   334      
Net loss (20,402,176) (20,402,176)
Registered direct and ATM common stock offerings $ 72,964 17,837,437 17,910,401
Registered direct and ATM common stock offerings, shares 7,296,352          
Exercise of common stock warrants $ 76,171 21,064,133 21,140,304
Exercise of common stock warrants, shares 7,617,148          
Shares issued to satisfy certain obligations $ 1,301 233,771 235,072
Shares issued to satisfy certain obligations, shares 130,055          
Realized and unrealized gains and losses, net, on investments securities (10,164) (10,164)
Stock-based compensation expense 1,105,245 1,105,245
Issuance of restricted stock $ 34 (34)
Issuance of restricted stock, shares 3,357          
Modification of warrant exercise prices 345,685 345,685
Deemed dividend related to warrant exercise price modifications (345,685) (345,685)
Effect of reverse stock split $ (3) 3
Effect of reverse stock split, shares (65)          
Balance at Dec. 31, 2017 $ 172,772 288,408,976 $ (85,188) (10,164) (261,781,888) 26,704,508
Balance, shares at Dec. 31, 2017 17,276,965   334      
Net loss (11,883,359) (11,883,359)
Realized and unrealized gains and losses, net, on investments securities 40,036 40,036
Stock-based compensation expense 4,604,415 4,604,415
Issuance of restricted stock $ 123 29,718 29,841
Issuance of restricted stock, shares 12,250          
Sale of equity through ATM and common stock purchase agreement $ 5,572 983,528 989,100
Sale of equity through ATM and common stock purchase agreement, shares 557,070          
Common stock issuance in exchange for cancellation of common stock warrants $ 8,207 (138,792) (130,585)
Common stock issuance in exchange for cancellation of common stock warrants, shares 820,714          
Common stock and warrants to purchase common stock issued in connection with equity and debt facilities $ 1,648 505,468 507,116
Common stock and warrants to purchase common stock issued in connection with equity and debt facilities, shares 164,835          
Balance at Dec. 31, 2018 $ 188,322 $ 294,393,313 $ (85,188) $ 29,872 $ (273,665,247) $ 20,861,072
Balance, shares at Dec. 31, 2018 18,831,834   334