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Consolidated Statements of Changes in Stockholders' Equity (Unaudited) - USD ($)
Common Stock [Member]
Additional Paid in Capital [Member]
Treasury Stock [Member]
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit [Member]
Total
Balance at Dec. 31, 2017 $ 172,772 $ 288,408,976 $ (85,188) $ (10,164) $ (261,781,888) $ 26,704,508
Balance, shares at Dec. 31, 2017 17,276,965   334      
Net loss (4,476,995) (4,476,995)
Sale of equity through ATM purchase agreement $ 4,571 1,232,013   1,236,584
Sale of equity through ATM purchase agreement, shares 457,070          
Realized and unrealized gains and losses, net, on investments securities (23,250) (23,250)
Stock-based compensation expense 153,668 153,668
Issuance of restricted stock $ 60 15,780 15,840
Issuance of restricted stock, shares 6,000          
Balance at Mar. 31, 2018 $ 177,403 289,810,437 334 (85,188) (266,258,883) 23,610,355
Balance, shares at Mar. 31, 2018 17,740,035          
Balance at Dec. 31, 2018 $ 188,322 294,393,313 $ (85,188) 29,872 (273,665,247) 20,861,072
Balance, shares at Dec. 31, 2018 18,831,834   334      
Net loss (2,367,452) (2,367,452)
Sale of equity through equity financing facilities $ 8,222 1,746,663 1,754,885
Sale of equity through equity financing facilities, shares 822,186          
Common stock warrants issued in connection with amendment to modify GEN-1 earn-out milestone payments 400,000 400,000
Realized and unrealized gains and losses, net, on investments securities 56,952 56,952
Stock-based compensation expense 691,145 691,145
Issuance of restricted stock $ 80 (80)
Issuance of restricted stock, shares 8,000          
Balance at Mar. 31, 2019 $ 196,624 $ 297,231,041 $ 334 $ (85,188) $ (276,032,699) $ 21,396,602
Balance, shares at Mar. 31, 2019 19,662,020