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Condensed Consolidated Statements of Changes in Stockholders Equity (Unaudited) - USD ($) | Common Stock [Member] | Additional Paid in Capital [Member] | Treasury Stock [Member] | Accumulated Other Comprehensive Income [Member] | Accumulated Deficit [Member] | Total
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2017 | $ 172,772 | $ 288,408,976 | $ (85,188) | $ (10,164) | $ (261,781,888) | $ 26,704,508
Balance, shares at Dec. 31, 2017 | 17,276,965 |  | 334 |  |  |
Net loss |  |  |  |  | (12,707,551) | (12,707,551)
Sale of equity through ATM purchase agreement | $ 4,571 | 1,232,013 |  |  |  | 1,236,584
Sale of equity through ATM purchase agreement, shares | 457,070 |  |  |  |  |
Warrants issued in connection with debt facility |  | 507,116 |  |  |  | 507,116
Realized and unrealized gains and losses, net, on investments securities |  |  |  | 5,917 |  | 5,917
Stock-based compensation expense |  | 3,371,301 |  |  |  | 3,371,301
Issuance of restricted stock | $ 123 | 29,718 |  |  |  | 29,841
Issuance of restricted stock, shares | 12,250 |  |  |  |  |
Balance at Jun. 30, 2018 | $ 177,466 | 293,549,124 | $ (85,188) | (4,247) | (274,489,439) | 19,147,716
Balance, shares at Jun. 30, 2018 | 17,746,285 |  | 334 |  |  |
Balance at Mar. 31, 2018 | $ 177,403 | 289,810,437 | $ (85,188) | (33,414) | (266,258,883) | 23,610,355
Balance, shares at Mar. 31, 2018 | 17,740,035 |  | 334 |  |  |
Net loss |  |  |  |  | (8,230,556) | (8,230,556)
Warrants issued in connection with debt facility |  | 507,116 |  |  |  | 507,116
Realized and unrealized gains and losses, net, on investments securities |  |  |  | 29,167 |  | 29,167
Stock-based compensation expense |  | 3,217,633 |  |  |  | 3,217,633
Issuance of restricted stock | $ 63 | 13,938 |  |  |  | 14,001
Issuance of restricted stock, shares | 6,250 |  |  |  |  |
Balance at Jun. 30, 2018 | $ 177,466 | 293,549,124 | $ (85,188) | (4,247) | (274,489,439) | 19,147,716
Balance, shares at Jun. 30, 2018 | 17,746,285 |  | 334 |  |  |
Balance at Dec. 31, 2018 | $ 188,322 | 294,393,313 | $ (85,188) | 29,872 | (273,665,247) | 20,861,072
Balance, shares at Dec. 31, 2018 | 18,831,834 |  | 334 |  |  |
Net loss |  |  |  |  | (8,271,967) | (8,271,967)
Realized and unrealized gains and losses, net, on investments securities |  |  |  | 64,704 |  | 64,704
Stock-based compensation expense |  | 1,308,492 |  |  |  | 1,308,492
Issuance of restricted stock | $ 105 | 5,245 |  |  |  | 5,350
Issuance of restricted stock, shares | 10,500 |  |  |  |  |
Sale of equity through equity financing facilities | $ 21,599 | 4,442,461 |  |  |  | 4,464,060
Sale of equity through equity financing facilities, shares | 2,159,961 |  |  |  |  |
Common stock warrants issued in connection with amendment to modify GEN-1 earn-out milestone payments |  | 400,000 |  |  |  | 400,000
Balance at Jun. 30, 2019 | $ 210,026 | 300,549,511 | $ (85,188) | 94,576 | (281,937,214) | 18,831,711
Balance, shares at Jun. 30, 2019 | 21,002,295 |  | 334 |  |  |
Balance at Mar. 31, 2019 | $ 196,624 | 297,231,041 | $ (85,188) | 86,824 | (276,032,699) | 21,396,602
Balance, shares at Mar. 31, 2019 | 19,662,020 |  | 334 |  |  |
Net loss |  |  |  |  | (5,904,515) | (5,904,515)
Realized and unrealized gains and losses, net, on investments securities |  |  |  | 7,752 |  | 7,752
Stock-based compensation expense |  | 617,347 |  |  |  | 617,347
Issuance of restricted stock | $ 24 | 5,325 |  |  |  | 5,349
Issuance of restricted stock, shares | 2,500 |  |  |  |  |
Sale of equity through equity financing facilities | $ 13,378 | 2,695,798 |  |  |  | 2,709,176
Sale of equity through equity financing facilities, shares | 1,337,775 |  |  |  |  |
Balance at Jun. 30, 2019 | $ 210,026 | $ 300,549,511 | $ (85,188) | $ 94,576 | $ (281,937,214) | $ 18,831,711
Balance, shares at Jun. 30, 2019 | 21,002,295 |  | 334 |  |  |

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