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Condensed Consolidated Statements of Changes in Stockholders' Equity (Unaudited) - USD ($) | Common Stock [Member] | Additional Paid in Capital [Member] | Treasury Stock [Member] | Accumulated Other Comprehensive Income [Member] | Accumulated Deficit [Member] | Total
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2017 | $ 172,772 | $ 288,408,976 | $ (85,188) | $ (10,164) | $ (261,781,888) | $ 26,704,508
Balance, shares at Dec. 31, 2017 | 17,276,965 |  | 334 |  |  |
Net loss |  |  |  |  | (17,363,937) | (17,363,937)
Sale of equity through ATM purchase agreement | $ 4,571 | 1,232,013 |  |  |  | 1,236,584
Sale of equity through ATM purchase agreement, shares | 457,070 |  |  |  |  |
Common stock and warrants to purchase common stock issued in connection with equity and debt facilities | $ 1,648 | 505,468 |  |  |  | 507,116
Common stock and warrants to purchase common stock issued in connection with equity and debt facilities, shares | 164,835 |  |  |  |  |
Realized and unrealized gains and losses, net, on investments securities |  |  |  | 31,124 |  | 31,124
Stock-based compensation expense |  | 3,985,829 |  |  |  | 3,985,829
Issuance of restricted stock | $ 123 | 29,718 |  |  |  | 29,841
Issuance of restricted stock, shares | 12,250 |  |  |  |  |
Balance at Sep. 30, 2018 | $ 179,114 | 294,162,004 | $ (85,188) | 20,960 | (279,145,825) | 15,131,065
Balance, shares at Sep. 30, 2018 | 17,911,120 |  | 334 |  |  |
Balance at Jun. 30, 2018 | $ 177,466 | 293,549,124 | $ (85,188) | (4,247) | (274,489,439) | 19,147,716
Balance, shares at Jun. 30, 2018 | 17,746,285 |  | 334 |  |  |
Net loss |  |  |  |  | (4,656,386) | (4,656,386)
Common stock issued in connection with equity facilities | $ 1,648 | (1,648) |  |  |  |
Common stock issued in connection with equity facilities, shares | 164,835 |  |  |  |  |
Realized and unrealized gains and losses, net, on investments securities |  |  |  | 25,207 |  | 25,207
Stock-based compensation expense |  | 614,528 |  |  |  | 614,528
Balance at Sep. 30, 2018 | $ 179,114 | 294,162,004 | $ (85,188) | 20,960 | (279,145,825) | 15,131,065
Balance, shares at Sep. 30, 2018 | 17,911,120 |  | 334 |  |  |
Balance at Dec. 31, 2018 | $ 188,322 | 294,393,313 | $ (85,188) | 29,872 | (273,665,247) | 20,861,072
Balance, shares at Dec. 31, 2018 | 18,831,834 |  | 334 |  |  |
Net loss |  |  |  |  | (13,748,774) | (13,748,774)
Realized and unrealized gains and losses, net, on investments securities |  |  |  | 4,203 |  | 4,203
Stock-based compensation expense |  | 1,762,172 |  |  |  | 1,762,172
Issuance of restricted stock | $ 255 | 5,095 |  |  |  | 5,350
Issuance of restricted stock, shares | 25,500 |  |  |  |  |
Sale of equity through equity financing facilities | $ 31,451 | 6,144,076 |  |  |  | 6,175,527
Sale of equity through equity financing facilities, shares | 3,145,084 |  |  |  |  |
Common stock warrants issued in connection with amendment to modify GEN-1 earn-out milestone payments |  | 400,000 |  |  |  | 400,000
Balance at Sep. 30, 2019 | $ 220,028 | 302,704,656 | $ (85,188) | 34,075 | (287,414,021) | 15,459,550
Balance, shares at Sep. 30, 2019 | 22,002,418 |  | 334 |  |  |
Balance at Jun. 30, 2019 | $ 210,026 | 300,549,511 | $ (85,188) | 94,576 | (281,937,214) | 18,831,711
Balance, shares at Jun. 30, 2019 | 21,002,295 |  | 334 |  |  |
Net loss |  |  |  |  | (5,476,807) | (5,476,807)
Realized and unrealized gains and losses, net, on investments securities |  |  |  | (60,501) |  | (60,501)
Stock-based compensation expense |  | 453,680 |  |  |  | 453,680
Issuance of restricted stock | $ 150 | (150) |  |  |  |
Issuance of restricted stock, shares | 15,000 |  |  |  |  |
Sale of equity through equity financing facilities | $ 9,852 | 1,701,615 |  |  |  | 1,711,467
Sale of equity through equity financing facilities, shares | 985,123 |  |  |  |  |
Balance at Sep. 30, 2019 | $ 220,028 | $ 302,704,656 | $ (85,188) | $ 34,075 | $ (287,414,021) | $ 15,459,550
Balance, shares at Sep. 30, 2019 | 22,002,418 |  | 334 |  |  |

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