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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
Common Stock [Member]
Additional Paid in Capital [Member]
Treasury Stock [Member]
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit [Member]
Total
Balance at Dec. 31, 2017 $ 172,772 $ 288,408,976 $ (85,188) $ (10,164) $ (261,781,888) $ 26,704,508
Balance, shares at Dec. 31, 2017 17,276,965   334      
Net loss (11,883,359) (11,883,359)
Sale of equity through ATM and common stock purchase agreement $ 5,572 983,528 989,100
Sale of equity through ATM and common stock purchase agreement, shares 557,070        
Common stock issuance in exchange for cancellation of common stock warrants $ 8,207 (138,792) (130,585)
Common stock issuance in exchange for cancellation of common stock warrants, shares 820,714        
Common stock and warrants to purchase common stock issued in connection with equity and debt facilities $ 1,648 505,468 507,116
Common stock and warrants to purchase common stock issued in connection with equity and debt facilities, shares 164,835        
Realized and unrealized gains and losses, net, on investments securities 40,036 40,036
Stock-based compensation expense 4,604,415 4,604,415
Issuance of restricted stock $ 123 29,718 29,841
Issuance of restricted stock, shares 12,250          
Balance at Dec. 31, 2018 $ 188,322 294,393,313 $ (85,188) 29,872 (273,665,247) 20,861,072
Balance, shares at Dec. 31, 2018 18,831,834   334      
Net loss (16,851,533) (16,851,533)
Realized and unrealized gains and losses, net, on investments securities 12,906 12,906
Stock-based compensation expense 2,286,388 2,286,388
Issuance of restricted stock $ 380 4,970 5,350
Issuance of restricted stock, shares 38,000        
Sale of equity through equity financing facilities $ 43,860 7,800,992 7,844,852
Sale of equity through equity financing facilities, shares 4,385,984        
Common stock warrants issued in connection with amendment to modify GEN-1 earn-out milestone payments 400,000 400,000
Balance at Dec. 31, 2019 $ 232,562 $ 304,885,663 $ (85,188) $ 42,778 $ (290,516,780) $ 14,559,035
Balance, shares at Dec. 31, 2019 23,255,818   334