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Consolidated Statements of Changes in Stockholders' Equity - USD ($) | Common Stock Outstanding [Member] | Additional Paid-In Capital [Member] | Treasury Stock [Member] | Accumulated Other Comprehensive Income [Member] | Accumulated Deficit [Member] | Total
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2018 | $ 188,322 | $ 294,393,313 | $ (85,188) | $ 29,872 | $ (273,665,247) | $ 20,861,072
Balance, shares at Dec. 31, 2018 | 18,831,834 |  | 334 |  |  |
Net loss |  |  |  |  | (16,851,533) | (16,851,533)
Sale of equity through equity financing facilities | $ 43,860 | 7,800,992 |  |  |  | 7,844,852
Sale of equity through equity financing facilities, shares | 4,385,984 |  |  |  |  |
Common stock warrants issued in connection with amendment to modify GEN-1 earn-out milestone payments |  | 400,000 |  |  |  | 400,000
Issuance of restricted stock | $ 380 | 4,970 |  |  |  | 5,350
Issuance of restricted stock, shares | 38,000 |  |  |  |  |
Realized and unrealized gains and losses, net, on investment securities |  |  |  | 12,906 |  | 12,906
Stock-based compensation expense |  | 2,286,388 |  |  |  | 2,286,388
Balance at Dec. 31, 2019 | $ 232,562 | 304,885,663 | $ (85,188) | 42,778 | (290,516,780) | 14,559,035
Balance, shares at Dec. 31, 2019 | 23,255,818 |  | 334 |  |  |
Net loss |  |  |  |  | (21,483,561) | (21,483,561)
Sale of equity through equity financing facilities | $ 166,741 | 22,644,928 |  |  |  | 22,811,669
Sale of equity through equity financing facilities, shares | 16,674,225 |  |  |  |  |
Issuance of restricted stock |  |  |  |  |  |
Issuance of common stock upon exercise of options and vesting of stock awards | $ 1,439 | 370,456 |  |  |  | 371,895
Issuance of common stock upon exercise of options and vesting of stock awards, shares | 143,864 |  |  |  |  |
Issuance of common stock upon exercise of common stock warrants | $ 1,973 | (1,973) |  |  |  |
Issuance of common stock upon exercise of common stock warrants,shares | 197,260 |  |  |  |  |
Common stock issued to settle accrued bonuses | $ 4,299 | 494,333 |  |  |  | 498,632
Common stock issued to settle accrued bonuses, shares | 429,855 |  |  |  |  |
Common stock warrants issued in exchange for services |  | 44,798 |  |  |  | 44,798
Realized and unrealized gains and losses, net, on investment securities |  |  |  | (42,778) |  | (42,778)
Stock-based compensation expense |  | 1,851,391 |  |  |  | 1,851,391
Balance at Dec. 31, 2020 | $ 407,014 | $ 330,289,596 | $ (85,188) |  | $ (312,000,341) | $ 18,611,081
Balance, shares at Dec. 31, 2020 | 40,701,022 |  | 334 |  |  |

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