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Stockholders' Equity (Details Narrative) - USD ($)							1 Months Ended	2 Months Ended	12 Months Ended
	Jan. 22, 2021	Sep. 08, 2020	Jun. 22, 2020	Feb. 27, 2020	Dec. 04, 2018	Aug. 31, 2018	Sep. 30, 2018	Mar. 05, 2020	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018	Sep. 21, 2020	Mar. 12, 2020
Shelf registration statement amount							$ 75,000,000
Proceeds from issuance of common stock										$ 22,811,669	$ 7,844,852
Warrants term													4 years
Warrants exercise price										$ 0.01	$ 0.01		$ 0.79
Common Stock Outstanding [Member]
Stock issued during period, shares, new issues			2,666,667
Proceeds from issuance of common stock			$ 9,100,000
Capital on DemandTM Sales Agreement [Member]
Aggregate offering price					$ 16,000,000
Capital on Demand Agreement [Member]
Stock issued during period, shares, new issues										5,200,000	500,000
Proceeds from issuance of common stock										$ 6,200,000	$ 1,000,000
Capital on Demand Agreement [Member] | Forecast [Member]
Stock issued during period, shares, new issues									7,200,000
Proceeds from issuance of common stock									$ 6,900,000
Securities Purchase Agreement [Member]
Stock issued during period, shares, new issues				4,571,428
Proceeds from issuance of common stock				$ 4,800,000
Shares issued, price per share				$ 1.05
Securities Purchase Agreement [Member] | Original Warrants [Member]
Number of warrants to purchase common stock				2,971,428
Warrants term				5 years
Warrants exercise price				$ 1.15
Securities Purchase Agreement [Member] | Forecast [Member]
Stock issued during period, shares, new issues	25,925,925
Proceeds from issuance of common stock	$ 35,000,000
Shares issued, price per share	$ 1.35
Placement agent fee description	The Company agreed to pay the January 2021 Placement Agents a cash fee equal to 7% of the aggregate gross proceeds raised from the sale of the securities sold in the January 2021 Offering and reimburse the January 2021 Placement Agents for certain of their expenses in an amount not to exceed $82,500.
Exchange Agreements [Member] | Warrant [Member]
Number of warrants to purchase common stock														3,200,000
Warrants term														5 years
Warrants exercise price														$ 1.24
Exchange Agreements [Member] | Forecast [Member]
Number of warrants to purchase common stock									1,200,000
Proceeds from issuance of warrants									$ 1,500,000
Underwriting Agreement [Member] | Underwritten Offering [Member]
Stock issued during period, shares, new issues			2,666,667
Proceeds from issuance of common stock			$ 9,100,000
Shares issued, price per share			$ 3.75
Shares purchased, price per share			3.4875
Underwriting discount price per share			$ 0.2625
Percentage of underwriting discount on public offering price			0.70%
LPC Purchase Agreement [Member]
Stock issued during period, shares, new issues										3,300,000
Proceeds from issuance of common stock										$ 2,200,000
LPC Purchase Agreement [Member] | Lincoln Park Capital Fund, LLC [Member]
Stock issued during period, shares, new issues		26,000,000
Sale of stock, description of transaction		Over the 36-month term of the LPC Purchase Agreement, we have the right, but not the obligation, from time to time, in our sole discretion and subject to certain conditions, including that the closing price of our Common Stock is not below $0.25 per share, to direct Lincoln Park to purchase up to an aggregate amount of $26.0 million (subject to certain limitations) of shares of Common Stock. Under the Purchase Agreement, on any business day selected by us, we may direct Lincoln Park to purchase up to 400,000 shares (the "Regular Purchase Share Limit") of our Common Stock (each such purchase, a "Regular Purchase"). Lincoln Park's maximum obligation under any single Regular Purchase will not exceed $1,500,000 unless we mutually agree to increase the maximum amount of such Regular Purchase.
Equity method investment, ownership percentage		9.99%
LPC Purchase Agreement [Member] | Exchange Cap of Common Stock [Member] | Lincoln Park Capital Fund, LLC [Member]
Stock issued during period, shares, new issues		6,688,588
LPC Purchase Agreement [Member] | LPC Commitment Shares [Member] | Lincoln Park Capital Fund, LLC [Member]
Stock issued during period, shares, new issues		437,828
LPC Purchase Agreement [Member] | Common Stock Outstanding [Member] | Lincoln Park Capital Fund, LLC [Member]
Aggregate offering price		$ 1,000,000
Stock issued during period, shares, new issues		1,000,000
Shares issued, price per share		$ 1.00
Regular Purchase Share Limit [Member] | Lincoln Park Capital Fund, LLC [Member]
Sale of stock, description of transaction		If we direct Lincoln Park to purchase the maximum number of shares of Common Stock we then may sell in a Regular Purchase, then in addition to such Regular Purchase, and subject to certain conditions and limitations in the LPC Purchase Agreement, we may direct Lincoln Park to make an "accelerated purchase" of an additional amount of Common Stock that may not exceed the lesser of (i) 300% of the number of shares purchased pursuant to the corresponding Regular Purchase and (ii) 30% of the total number of shares of our Common Stock traded on The Nasdaq Capital Market during a specified period on the applicable purchase date as set forth in the Purchase Agreement. Under certain circumstances and in accordance with the Purchase Agreement, the Company may direct Lincoln Park to purchase shares in multiple accelerated purchases on the same trading day.
Regular Purchase Share Limit [Member] | Lincoln Park Capital Fund, LLC [Member] | Maximum [Member]
Stock issued during period, shares, new issues		400,000
2019 Aspire Purchase Agreements [Member]
Stock issued during period, shares, new issues								1,000,000		500,000
Proceeds from issuance of common stock								$ 1,600,000		$ 700,000
Aggregate offering price, additions						$ 15,000,000				$ 10,000,000
Aggregate offering price, term						24 months				24 months
2018 Aspire Purchase Agreements [Member]
Stock issued during period, shares, new issues											3,300,000	100,000
Proceeds from issuance of common stock											$ 6,300,000	$ 200,000

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