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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
Common Stock Outstanding [Member]
Additional Paid-In Capital [Member]
Treasury Stock [Member]
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit [Member]
Total
Balance at Dec. 31, 2018 $ 188,322 $ 294,393,313 $ (85,188) $ 29,872 $ (273,665,247) $ 20,861,072
Balance, shares at Dec. 31, 2018 18,831,834   334      
Net loss (16,851,533) (16,851,533)
Sale of equity through equity financing facilities $ 43,860 7,800,992 7,844,852
Sale of equity through equity financing facilities, shares 4,385,984        
Common stock warrants issued in connection with amendment to modify GEN-1 earn-out milestone payments 400,000 400,000
Issuance of restricted stock $ 380 4,970 5,350
Issuance of restricted stock, shares 38,000        
Realized and unrealized gains and losses, net, on investment securities 12,906 12,906
Stock-based compensation expense 2,286,388 2,286,388
Balance at Dec. 31, 2019 $ 232,562 304,885,663 $ (85,188) 42,778 (290,516,780) 14,559,035
Balance, shares at Dec. 31, 2019 23,255,818   334      
Net loss (21,483,561) (21,483,561)
Sale of equity through equity financing facilities $ 166,741 22,644,928 22,811,669
Sale of equity through equity financing facilities, shares 16,674,225        
Issuance of restricted stock        
Issuance of common stock upon exercise of options and vesting of stock awards $ 1,439 370,456 371,895
Issuance of common stock upon exercise of options and vesting of stock awards, shares 143,864        
Issuance of common stock upon exercise of common stock warrants $ 1,973 (1,973)
Issuance of common stock upon exercise of common stock warrants,shares 197,260        
Common stock issued to settle accrued bonuses $ 4,299 494,333 498,632
Common stock issued to settle accrued bonuses, shares 429,855          
Common stock warrants issued in exchange for services 44,798 44,798
Realized and unrealized gains and losses, net, on investment securities (42,778) (42,778)
Stock-based compensation expense 1,851,391 1,851,391
Balance at Dec. 31, 2020 $ 407,014 $ 330,289,596 $ (85,188) $ (312,000,341) $ 18,611,081
Balance, shares at Dec. 31, 2020 40,701,022   334